| Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila. | Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila.
Fang HY, Forghani R, Clarke A, McQueen PG, Chandrasekaran A, O'Neill KM, Losert W, Papoian GA, Giniger E., Free PMC Article | 06/26/2023 |
| Enabled/VASP is required to mediate proper sealing of opposing cardioblasts during Drosophila dorsal vessel formation. | Enabled/VASP is required to mediate proper sealing of opposing cardioblasts during Drosophila dorsal vessel formation.
King TR, Kramer J, Cheng YS, Swope D, Kramer SG. | 04/2/2022 |
| Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function. | Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function.
McNeill EM, Thompson C, Berke B, Chou VT, Rusch J, Duckworth A, DeProto J, Taylor A, Gates J, Gertler F, Keshishian H, Van Vactor D., Free PMC Article | 08/28/2021 |
| Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena. | Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
Kiss V, Jipa A, Varga K, Takáts S, Maruzs T, Lőrincz P, Simon-Vecsei Z, Szikora S, Földi I, Bajusz C, Tóth D, Vilmos P, Gáspár I, Ronchi P, Mihály J, Juhász G., Free PMC Article | 07/3/2021 |
| Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors. | Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
Yaniv SP, Meltzer H, Alyagor I, Schuldiner O., Free PMC Article | 02/20/2021 |
| this study shows that Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis during inflammation | Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis.
Davidson AJ, Millard TH, Evans IR, Wood W., Free PMC Article | 06/6/2020 |
| The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase. | The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.
Kannan R, Song JK, Karpova T, Clarke A, Shivalkar M, Wang B, Kotlyanskaya L, Kuzina I, Gu Q, Giniger E., Free PMC Article | 09/9/2017 |
| Abl/Ena signaling controls the subcellular architecture of the Golgi complex in Drosophila photoreceptor neurons through its regulation of the Golgi-associated actin cytoskeleton. | The Abl/enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons.
Kannan R, Kuzina I, Wincovitch S, Nowotarski SH, Giniger E., Free PMC Article | 06/20/2015 |
| the activities of Ena/VASP and the WAVE regulatory complex are intimately linked to ensure optimal control of actin polymerization during cell migration and development | Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton.
Chen XJ, Squarr AJ, Stephan R, Chen B, Higgins TE, Barry DJ, Martin MC, Rosen MK, Bogdan S, Way M., Free PMC Article | 11/22/2014 |
| Ena is both sufficient and necessary to account for miR-8-mediated regulation of subsynaptic reticulum architecture. | miR-8 controls synapse structure by repression of the actin regulator enabled.
Loya CM, McNeill EM, Bao H, Zhang B, Van Vactor D., Free PMC Article | 06/14/2014 |
| Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle. | Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin.
Winkelman JD, Bilancia CG, Peifer M, Kovar DR., Free PMC Article | 05/31/2014 |
| EnaEVH1 binds Dia directly and inhibits DiaFH1FH2-mediated nucleation in vitro | Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo.
Bilancia CG, Winkelman JD, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M., Free PMC Article | 04/26/2014 |
| Ena regulates force balance in the somatic gonadal precursors by sequestering DE-cad, leading to the morphogenetic movement required for gonad compaction. | The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis.
Sano H, Kunwar PS, Renault AD, Barbosa V, Clark IB, Ishihara S, Sugimura K, Lehmann R., Free PMC Article | 06/29/2013 |
| Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure | The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled.
Choi W, Jung KC, Nelson KS, Bhat MA, Beitel GJ, Peifer M, Fanning AS., Free PMC Article | 12/10/2011 |
| Ena localises to regions of actin dynamics within migrating haemocytes, stimulates lamellipodial dynamics and positively regulates the number and length of filopodia. | Ena drives invasive macrophage migration in Drosophila embryos.
Tucker PK, Evans IR, Wood W., Free PMC Article | 04/9/2011 |
| Enabled and Capping actin regulator proteins shape oogenesis. | Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.
Gates J, Nowotarski SH, Yin H, Mahaffey JP, Bridges T, Herrera C, Homem CC, Janody F, Montell DJ, Peifer M., Free PMC Article | 01/21/2010 |
| Drosophila enabled/vasodilator stimulated phosphoprotein (Ena/VASP) proteins are candidates for driving cytoskeleton modulation under the membrane. | Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP.
Trichet L, Sykes C, Plastino J., Free PMC Article | 01/21/2010 |
| Ena modulates filopodial number and length, thus influencing the speed of epithelial zippering and the ability of cells to match with correct neighbors in embryonic morphogenesis. | Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila.
Gates J, Mahaffey JP, Rogers SL, Emerson M, Rogers EM, Sottile SL, Van Vactor D, Gertler FB, Peifer M. | 01/21/2010 |
| Ena/VASP, when not inhibited by the Abl pathway, can bind kinesin heavy chain and reduce its transport activity in axons | Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1.
Martin M, Ahern-Djamali SM, Hoffmann FM, Saxton WM., Free PMC Article | 01/21/2010 |
| In abl mutants, Enabled accumulates ectopically at the apical cortex where excess actin is observed, suggesting that Abl regulates Ena's subcellular localization. | Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled.
Grevengoed EE, Fox DT, Gates J, Peifer M., Free PMC Article | 01/21/2010 |
| Enabled (Ena), a substrate for Abl, promotes the formation of both dendritic branches and actin-rich spine-like protrusions of dendritic arborization neurons, an effect opposite to that of Abl | Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila.
Li W, Li Y, Gao FB. | 01/21/2010 |