| Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3. | Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3.
Tsilifis C, Spegarova JS, Good R, Griffin H, Engelhardt KR, Graham S, Hughes S, Arkwright PD, Hambleton S, Gennery AR., Free PMC Article | 04/24/2024 |
| Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency. | Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency.
Liongue C, Ratnayake T, Basheer F, Ward AC., Free PMC Article | 03/20/2024 |
| Dependence of peripheral T-cell lymphoma on constitutively activated JAK3: Implication for JAK3 inhibition as a therapeutic approach. | Dependence of peripheral T-cell lymphoma on constitutively activated JAK3: Implication for JAK3 inhibition as a therapeutic approach.
Le K, Vollenweider J, Han J, Staudinger N, Stenson M, Bayraktar L, Wellik LE, Maurer MJ, McPhail ED, Witzig TE, Gupta M. | 02/7/2024 |
| Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement. | Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement.
Zhao Y, Mu Y, Zou Y, He Z, Lu T, Wang X, Li W, Gao B., Free PMC Article | 01/26/2024 |
| New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma. | New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma.
Velatooru LR, Hu CH, Bijani P, Wang X, Bojaxhi P, Chen H, Duvic M, Ni X., Free PMC Article | 11/28/2023 |
| Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation. | Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation.
Basheer F, Lee E, Liongue C, Ward AC., Free PMC Article | 11/12/2022 |
| Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma. | Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma.
Long Q, Huang C, Huang J, Meng Q, Cheng Y, Li Y, He L, Chen M, Zhang C, Wang X, Zhu W, Peng J, Shi D, Zheng F, Dong P, Deng W., Free PMC Article | 10/1/2022 |
| JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia. | JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia.
Bodaar K, Yamagata N, Barthe A, Landrigan J, Chonghaile TN, Burns M, Stevenson KE, Devidas M, Loh ML, Hunger SP, Wood B, Silverman LB, Teachey DT, Meijerink JP, Letai A, Gutierrez A., Free PMC Article | 08/27/2022 |
| Generation of a chemical genetic model for JAK3. | Generation of a chemical genetic model for JAK3.
Remenyi J, Naik RJ, Wang J, Razsolkov M, Verano A, Cai Q, Tan L, Toth R, Raggett S, Baillie C, Traynor R, Hastie CJ, Gray NS, Arthur JSC., Free PMC Article | 10/23/2021 |
| STAT3 activation in thymic epithelial tumors: correlation with cyclin D1, JAK3, and clinical behavior. | STAT3 activation in thymic epithelial tumors: correlation with cyclin D1, JAK3, and clinical behavior.
Okabe N, Fujiwara M, Tachibana K, Tanaka R, Kondo H, Kamma H. | 10/16/2021 |
| Whole-exome sequencing of T(-) B(+) severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants. | Whole-exome sequencing of T(-) B(+) severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants.
El Hawary R, Meshaal S, Mauracher AA, Opitz L, Abd Elaziz D, Lotfy S, Eldash A, Boutros J, Galal N, Pachlopnik Schmid J, Elmarsafy A., Free PMC Article | 10/2/2021 |
| Atypical immune phenotype in severe combined immunodeficiency patients with novel mutations in IL2RG and JAK3. | Atypical immune phenotype in severe combined immunodeficiency patients with novel mutations in IL2RG and JAK3.
Goldberg L, Simon AJ, Lev A, Barel O, Stauber T, Kunik V, Rechavi G, Somech R. | 08/14/2021 |
| Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations. | Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.
Poli R, Scatolini M, Grosso E, Maletta F, Gallo M, Liscia D, Nelva A, Cesario F, Forte G, Metovic J, Volante M, Arvat E, Papotti M. | 07/17/2021 |
| JAK1 rs310241 and JAK3 rs3008 Genotypes May Increase Susceptibility to Psoriasis: A Case Control Study. | JAK1 rs310241 and JAK3 rs3008 Genotypes May Increase Susceptibility to Psoriasis: A Case Control Study.
Sayed KS, El-Komy MHM, Shehata H, ElShazly SH, El Desouky ED, Amr KS, ElAraby NM, AlOrbani AM. | 07/10/2021 |
| RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing. | RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing.
Wu J, Del Duca E, Espino M, Gontzes A, Cueto I, Zhang N, Estrada YD, Pavel AB, Krueger JG, Guttman-Yassky E., Free PMC Article | 07/3/2021 |
| Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing. | Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing.
Del Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E. | 06/19/2021 |
| JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma. | JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma.
Liang F, Liang H, Li Z, Huang P. | 05/22/2021 |
| JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma. | JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma.
Meng L, Ding L, Yu Y, Li W., Free PMC Article | 05/8/2021 |
| A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis. | A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis.
Miao W, Li L, Liu X, Qi TF, Guo L, Huang M, Wang Y., Free PMC Article | 11/21/2020 |
| Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene. | Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene.
Mittempergher L, Piskorz AM, Bosma AJ, Michaut M, Wisman GBA, Kluin RJC, Nieuwland M, Brugman W, van der Ven KJW, Marass F, Morris J, Rosenfeld N, Jimenez-Linan M, de Jong S, van der Zee AGJ, Brenton JD, Bernards R., Free PMC Article | 09/12/2020 |
| Germline mutation in JAK3 gene is associated with Racial Disparities in Head and Neck Cancer. | JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients.
Guerrero-Preston R, Lawson F, Rodriguez-Torres S, Noordhuis MG, Pirini F, Manuel L, Valle BL, Hadar T, Rivera B, Folawiyo O, Baez A, Marchionni L, Koch WM, Westra WH, Kim YJ, Eshleman JR, Sidransky D., Free PMC Article | 07/18/2020 |
| High JAK3 expression is associated with peripheral Tcell lymphoma expressing the ITKSYK fusion gene. | Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T‑cell lymphoma expressing the ITK‑SYK fusion gene.
Zhang LL, Pan HX, Wang YX, Guo T, Liu L., Free PMC Article | 03/14/2020 |
| Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil. | Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil.
de Araújo Santos FJ, da Silva LS, Júnior JDES, Ramos de Mesquita TG, de Souza MLG, de Andrade Júnior MC, Talhari S, Ramasawmy R., Free PMC Article | 03/7/2020 |
| Here we show that CRISPR/Cas9-mediated inactivation of Suz12 cooperates with mutant JAK3 to drive T-cell transformation and T-cell acute lymphoblastic leukemia development | Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.
Broux M, Prieto C, Demeyer S, Vanden Bempt M, Alberti-Servera L, Lodewijckx I, Vandepoel R, Mentens N, Gielen O, Jacobs K, Geerdens E, Vicente C, de Bock CE, Cools J., Free PMC Article | 02/8/2020 |
| Somatic JAK3 mutations in NK-cell enteropathy: histologic and mutational profiles. | Recurrent somatic JAK3 mutations in NK-cell enteropathy.
Xiao W, Gupta GK, Yao J, Jang YJ, Xi L, Baik J, Sigler A, Kumar A, Moskowitz AJ, Arcila ME, Raffeld M, Pittaluga S, Dogan A, Jaffe ES., Free PMC Article | 02/1/2020 |