| Depletion of superoxide dismutases promotes muscular and neuronal ROS accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults. | A correlation of reactive oxygen species accumulation by depletion of superoxide dismutases with age-dependent impairment in the nervous system and muscles of Drosophila adults.
Oka S, Hirai J, Yasukawa T, Nakahara Y, Inoue YH. | 04/16/2016 |
| Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance. | Paraquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome.
Narayanasamy SK, Simpson DC, Martin I, Grotewiel M, Gronert S., Free PMC Article | 10/31/2015 |
| The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions. | [Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability].
Vitushynska MV, Matiytsiv NP, Chernyk Y. | 06/20/2015 |
| ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS is not essential for oocyte viability | SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival.
Mukherjee S, Forde R, Belton A, Duttaroy A., Free PMC Article | 06/4/2011 |
| knockdown in the musculature has whole-organism consequences | Sod2 knockdown in the musculature has whole-organism consequences in Drosophila.
Martin I, Jones MA, Rhodenizer D, Zheng J, Warrick JM, Seroude L, Grotewiel M., Free PMC Article | 02/8/2010 |
| Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle. | Mitochondrial superoxide radicals differentially affect muscle activity and neural function.
Godenschwege T, Forde R, Davis CP, Paul A, Beckwith K, Duttaroy A., Free PMC Article | 02/1/2010 |
| Data show that the decline of several functional measures of aging occurs, in an accelerated fashion, in Sod2 mutants. | Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants.
Piazza N, Hayes M, Martin I, Duttaroy A, Grotewiel M, Wessells R., Free PMC Article | 01/21/2010 |
| switching moribund SOD2-deficient adults from normoxia into hypoxia arrests premature mortality and endows the survivors with a near-normal life | Hypoxia rescues early mortality conferred by superoxide dismutase deficiency.
Wicks S, Bain N, Duttaroy A, Hilliker AJ, Phillips JP. | 01/21/2010 |
| Disruption of the protective effects of SOD2 on mitochondria manifests as profound changes in behavioral and demographic aging as well as exacerbated age-related pathology in the nervous system. | Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging.
Paul A, Belton A, Nag S, Martin I, Grotewiel MS, Duttaroy A., Free PMC Article | 01/21/2010 |
| SOD1 and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress | Compartment-specific protection of iron-sulfur proteins by superoxide dismutase.
Missirlis F, Hu J, Kirby K, Hilliker AJ, Rouault TA, Phillips JP. | 01/21/2010 |
| The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression. | Genomic regions responsible for manganese superoxide dismutase regulation in Drosophila melanogaster.
Paul A, Duttaroy A. | 01/21/2010 |
| Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity. | Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster.
Orr WC, Mockett RJ, Benes JJ, Sohal RS. | 01/21/2010 |
| Overexpression of Cu,ZnSOD and MnSOD in transgenic Drosophila. | Overexpression of Cu,ZnSOD and MnSOD in transgenic Drosophila.
Mockett RJ, Orr WC, Sohal RS. | 01/21/2010 |
| Ablation of mitochondrial SOD2 through expression of a GAL4-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults. | RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.
Kirby K, Hu J, Hilliker AJ, Phillips JP., Free PMC Article | 01/21/2010 |