| ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates. | ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates.
Zhang R, Zhu G, Li Z, Meng Z, Huang H, Ding C, Wang Y, Chen C, Li Y, Liu H, Chen J., Free PMC Article | 05/7/2024 |
| LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity. | LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity.
Lacouture C, Chaves B, Guipouy D, Houmadi R, Duplan-Eche V, Allart S, Destainville N, Dupré L., Free PMC Article | 01/16/2024 |
| lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. | lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma.
Wang Q, Xiao G, Li N, Jiang X, Li C., Free PMC Article | 06/15/2023 |
| LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. | LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade.
Hickman A, Koetsier J, Kurtanich T, Nielsen MC, Winn G, Wang Y, Bentebibel SE, Shi L, Punt S, Williams L, Haymaker C, Chesson CB, Fa'ak F, Dominguez AL, Jones R, Kuiatse I, Caivano AR, Khounlo S, Warier ND, Marathi U, Market RV, Biediger RJ, Craft JW Jr, Hwu P, Davies MA, Woodside DG, Vanderslice P, Diab A, Overwijk WW, Hailemichael Y., Free PMC Article | 07/9/2022 |
| CD64, CD11a and CD18 leukocytes expression in children with SARS-CoV-2 multisystem inflammatory syndrome versus children with Kawasaki disease: Similar but not the same. | CD64, CD11a and CD18 leukocytes expression in children with SARS-CoV-2 multisystem inflammatory syndrome versus children with Kawasaki disease: Similar but not the same.
García-Salido A, Cuenca-Carcelén S, Castillo-Robleda A., Free PMC Article | 02/6/2021 |
| Aggregatibacter actinomycetemcomitans LtxA has a strong affinity for the cytosolic domains of both the alphaL and beta2 subunits (Kd = 15 and 4.2 nM, respectively) of human LFA-1 and a significantly lower affinity for the cytoplasmic domains of other integrin alphaM , alphaX , and beta3 subunits (Kd = 400, 180, and 230 nM, respectively), used as controls. | Aggregatibacter actinomycetemcomitans leukotoxin causes activation of lymphocyte function-associated antigen 1.
Nygren P, Balashova N, Brown AC, Kieba I, Dhingra A, Boesze-Battaglia K, Lally ET., Free PMC Article | 05/16/2020 |
| The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4(+) T cells of systemic lupus erythematous | The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4(+) T cells of systemic lupus erythematous.
Zhang C, Wang X, Chen Y, Wu Z, Zhang C, Shi W. | 09/21/2019 |
| LFA-1 cross-linking recruits and activates FAK1 and PYK2 to phosphorylate LAT selectively on a single Y-171 site that binds to the GRB2-SKAP1 complex and limits dwell times of T-cells with dendritic cells | LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.
Raab M, Lu Y, Kohler K, Smith X, Strebhardt K, Rudd CE., Free PMC Article | 12/22/2018 |
| Data show that integrin alphaLbeta2 (LFA-1) is oriented relative to actin retrograde flow. | Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration.
Nordenfelt P, Moore TI, Mehta SB, Kalappurakkal JM, Swaminathan V, Koga N, Lambert TJ, Baker D, Waters JC, Oldenbourg R, Tani T, Mayor S, Waterman CM, Springer TA., Free PMC Article | 10/20/2018 |
| These results demonstrated that histone demethylase JMJD3 regulates CD11a expression in lupus T cells by affecting the H3K27me3 levels in the ITGAL (CD11a) promoter region, and JMJD3 might thereby serve as a potential therapeutic target for SLE. | Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4+ T cells of patients with systemic lupus erythematosus.
Yin H, Wu H, Zhao M, Zhang Q, Long H, Fu S, Lu Q., Free PMC Article | 04/28/2018 |
| Data show a nadir of CD11a expression at 2 years of natalizumab treatment in multiple sclerosis, at the peak of incidence of progressive multifocal leukoencephalopathy, indirectly suggesting that a lack of these molecules may play a role in the onset of PML in NTZ-treated patients. | Natalizumab treatment alters the expression of T-cell trafficking marker LFA-1 α-chain (CD11a) in MS patients.
Jilek S, Mathias A, Canales M, Lysandropoulos A, Pantaleo G, Schluep M, Du Pasquier RA. | 01/27/2018 |
| Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor (CD11a/CD18) in natural killer cells. | Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor.
Swaim CD, Scott AF, Canadeo LA, Huibregtse JM., Free PMC Article | 11/25/2017 |
| Suggest possible role for lymphocyte CD11a in the pathogenesis immune thrombocytopenia. | Expression of CD11a in lymphocyte subpopulation in immune thrombocytopenia.
Liu YX, Zhang F, Yao QM, Yuan T, Xu J, Zhu XJ., Free PMC Article | 11/12/2016 |
| The alphaI domain, tethered through its N-linker and a disulfide to a stable beta-ribbon pillar near the center of the platform, can undergo pivoting and tilting motions that appear buffered by N-glycan decorations that differ between alphaL and alphaX subunits. | Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen M, Springer TA., Free PMC Article | 08/13/2016 |
| beta2 integrins-mediated chemosensory adhesion and migration of polymorphonuclear leukocytes on the vascular graft surface, bacterial cellulose. | β2 integrins (CD11/18) are essential for the chemosensory adhesion and migration of polymorphonuclear leukocytes on bacterial cellulose.
Kim GD, Lee SE, Yang H, Park HR, Son GW, Park CS, Park YS. | 12/19/2015 |
| Data show that interleukin-18 was involved in the eosinophil-mediated death of colon carcinoma cells via upregulation of CD11a/CD18 and ICAM-1 adhesion molecules. | IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1.
Gatault S, Delbeke M, Driss V, Sarazin A, Dendooven A, Kahn JE, Lefèvre G, Capron M. | 12/19/2015 |
| shear-induced CD11/CD18 cleavage is phenotypic of neutrophilic cells, including those derived from HL60 cells | Characterization of the shear stress regulation of CD18 surface expression by HL60-derived neutrophil-like cells.
Akenhead ML, Zhang X, Shin HY. | 09/26/2015 |
| Data show that leucocyte function-associated antigen-1 (integrin alphaLbeta2), DNAX accessory molecule-1 (DNAM-1) or tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) enhance osteoclast survival when co-cultured with activated NK cells. | Interleukin-15-activated natural killer cells kill autologous osteoclasts via LFA-1, DNAM-1 and TRAIL, and inhibit osteoclast-mediated bone erosion in vitro.
Feng S, Madsen SH, Viller NN, Neutzsky-Wulff AV, Geisler C, Karlsson L, Söderström K., Free PMC Article | 08/29/2015 |
| LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension. | FRET detection of lymphocyte function-associated antigen-1 conformational extension.
Chigaev A, Smagley Y, Haynes MK, Ursu O, Bologa CG, Halip L, Oprea T, Waller A, Carter MB, Zhang Y, Wang W, Buranda T, Sklar LA., Free PMC Article | 08/22/2015 |
| the blocking of LFA-1/ICAM-1 interaction resulted in a significant increase in the percentage of IL-17(+) T cells expanded in nonclassical monocyte/T-cell cocultures | Blocking of LFA-1 enhances expansion of Th17 cells induced by human CD14(+) CD16(++) nonclassical monocytes.
Traunecker E, Gardner R, Fonseca JE, Polido-Pereira J, Seitz M, Villiger PM, Iezzi G, Padovan E. | 08/8/2015 |
| Studied signaling mechanisms of Lymphocyte function-associated antigen-1 (LFA-1) using NMR analysis of the dynamics of the LFA-1 I-domain. | NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain.
Leung HT, Kukic P, Camilloni C, Bemporad F, De Simone A, Aprile FA, Kumita JR, Vendruscolo M., Free PMC Article | 07/25/2015 |
| CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to Behcet's disease in Koreans. | CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to Behçet's disease in Koreans.
Park SR, Park KS, Park YJ, Bang D, Lee ES. | 06/20/2015 |
| PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration. | Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.
Klahan S, Wu MS, Hsi E, Huang CC, Hou MF, Chang WC., Free PMC Article | 02/28/2015 |
| ITGAL is overexpressed in systemic lupus erythematosus CD4+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease. | Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus.
Balada E, Castro-Marrero J, Felip L, Ordi-Ros J, Vilardell-Tarrés M. | 10/18/2014 |
| there was reduced expression of CD11a, CD11b, and CD18 in trisomy 12 cases with NOTCH1 mutations compared with wild type. | Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.
Riches JC, O'Donovan CJ, Kingdon SJ, McClanahan F, Clear AJ, Neuberg DS, Werner L, Croce CM, Ramsay AG, Rassenti LZ, Kipps TJ, Gribben JG., Free PMC Article | 09/6/2014 |