| Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms. | Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms.
Zhan T, Zou Y, Han Z, Tian X, Chen M, Liu J, Yang X, Zhu Q, Liu M, Chen W, Chen M, Huang X, Tan J, Liu W, Tian X., Free PMC Article | 08/26/2024 |
| Non-transcriptional IRF7 interacts with NF-kappaB to inhibit viral inflammation. | Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation.
Fan S, Popli S, Chakravarty S, Chakravarti R, Chattopadhyay S., Free PMC Article | 05/8/2024 |
| IRF7: role and regulation in immunity and autoimmunity. | IRF7: role and regulation in immunity and autoimmunity.
Ma W, Huang G, Wang Z, Wang L, Gao Q., Free PMC Article | 08/30/2023 |
| Interferon regulatory factor 7 in inflammation, cancer and infection. | Interferon regulatory factor 7 in inflammation, cancer and infection.
Qing F, Liu Z., Free PMC Article | 06/2/2023 |
| Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection. | Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.
Li S, Zhu Z, Yang F, Cao W, Yang J, Ma C, Zhao Z, Tian H, Liu X, Ma J, Xiao S, Zheng H. | 01/8/2022 |
| Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection. | Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection.
Ohtani F, Miyazaki D, Shimizu Y, Haruki T, Yamagami S, Inoue Y., Free PMC Article | 11/13/2021 |
| ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis. | ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.
de Oliveira RTG, Cordeiro JVA, Vitoriano BF, de Lima Melo MM, Sampaio LR, de Paula Borges D, Magalhães SMM, Pinheiro RF. | 10/16/2021 |
| M2 macrophages contribute to cell proliferation and migration of breast cancer. | M2 macrophages contribute to cell proliferation and migration of breast cancer.
Tu D, Dou J, Wang M, Zhuang H, Zhang X. | 09/11/2021 |
| RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism. | RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
Senatus L, López-Díez R, Egaña-Gorroño L, Liu J, Hu J, Daffu G, Li Q, Rahman K, Vengrenyuk Y, Barrett TJ, Dewan MZ, Guo L, Fuller D, Finn AV, Virmani R, Li H, Friedman RA, Fisher EA, Ramasamy R, Schmidt AM., Free PMC Article | 06/12/2021 |
| Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway. | Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.
Yang D, Wang X, Gao H, Chen B, Si C, Wang S., Free PMC Article | 01/30/2021 |
| Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization. | Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization.
Dalskov L, Narita R, Andersen LL, Jensen N, Assil S, Kristensen KH, Mikkelsen JG, Fujita T, Mogensen TH, Paludan SR, Hartmann R., Free PMC Article | 01/2/2021 |
| IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation. | IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation.
He J, Yang Q, Xiao Q, Lei A, Li X, Zhou P, Liu T, Zhang L, Shi K, Yang Q, Dong J, Zhou J. | 10/24/2020 |
| A Quantitative Genetic Interaction Map of HIV Infection. | A Quantitative Genetic Interaction Map of HIV Infection.
Gordon DE, Watson A, Roguev A, Zheng S, Jang GM, Kane J, Xu J, Guo JZ, Stevenson E, Swaney DL, Franks-Skiba K, Verschueren E, Shales M, Crosby DC, Frankel AD, Marson A, Marazzi I, Cagney G, Krogan NJ., Free PMC Article | 08/15/2020 |
| These findings provide further support for the essential role of IRF7 in amplifying antiviral IFN responses to ensure potent and sustained IFN responses during influenza virus infection in humans. | Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza.
Thomsen MM, Jørgensen SE, Gad HH, Storgaard M, Gjedsted J, Christiansen M, Hartmann R, Mogensen TH. | 03/7/2020 |
| The findings suggest that HIV-1 may alter AKT phosphorylation to inhibit the translocation of IRF-7 into plasmacytoid dendritic cell nucleus, leading to IFN-alpha suppression, and this may be the reason for IFN-alpha abrogation observed in recently infected HIV patients. | HIV-1-Mediated Suppression of IFN-α Production Is Associated with Inhibition of IRF-7 Translocation and PI3K/akt Pathway in Plasmacytoid Dendritic Cells.
Dhamanage AS, Thakar MR, Paranjape RS. | 02/1/2020 |
| our findings demonstrate that asthma exacerbations in children can be divided into IRF7(hi) versus IRF7(lo) phenotypes with associated differences in clinical phenotypes | Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.
Khoo SK, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, McCrae C, Öberg L, Troy NM, Prastanti F, Everard J, Oo S, Borland ML, Maciewicz RA, Le Souëf PN, Laing IA, Bosco A. | 01/11/2020 |
| Virus nonstructural proteins directly interacted with and sequestered IRF7 to the inclusion bodies, demonstrating a view in which host innate immunity is suppressed by severe fever with thrombocytopenia syndrome virus through host-virus interaction. | Suppression of the IFN-α and -β Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection.
Hong Y, Bai M, Qi X, Li C, Liang M, Li D, Cardona CJ, Xing Z. | 10/26/2019 |
| the silence of the eIF4F complex suppressed the protein level of IRF1 and IRF7 that exert potent antiviral effects against rotavirus infection. | The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7.
Chen S, Feng C, Fang Y, Zhou X, Xu L, Wang W, Kong X, P Peppelenbosch M, Pan Q, Yin Y., Free PMC Article | 07/27/2019 |
| IRF3 and IRF7 bind to many interferon-stimulated response element (ISRE)-type sites in the virus-response elements (VREs) of IFN promoters. However, strikingly, IRF5 does not bind the VREs. | DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation.
Andrilenas KK, Ramlall V, Kurland J, Leung B, Harbaugh AG, Siggers T., Free PMC Article | 07/20/2019 |
| TARBP2 participates in the interaction between IRF7 and TRAF6, thereby suppressing TRAF6-mediated K63-linked ubiquitination of IRF7. | TARBP2 inhibits IRF7 activation by suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.
Ling T, Weng GX, Li J, Li C, Wang W, Cao L, Rao H, Ju C, Xu LG. | 05/11/2019 |
| Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans | Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R., Free PMC Article | 05/11/2019 |
| Upregulation of IRF7 in treated cancer cells promoted resistance to chemotherapy. | Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.
Lan Q, Peyvandi S, Duffey N, Huang YT, Barras D, Held W, Richard F, Delorenzi M, Sotiriou C, Desmedt C, Lorusso G, Rüegg C., Free PMC Article | 05/4/2019 |
| SOCS1/3-mediated degradation of IFN regulatory factor 7 directly regulates TLR7 signaling and type I IFN production in pDCs. | SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.
Yu CF, Peng WM, Schlee M, Barchet W, Eis-Hübinger AM, Kolanus W, Geyer M, Schmitt S, Steinhagen F, Oldenburg J, Novak N. | 04/13/2019 |
| Ablation of inflammsome components reduces SOCS1 induction, and relieves its inhibition on MyD88-IRF7-dependent-IFN-I signaling, leading to high levels of IFN-alpha/beta production and host survival. | Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity.
Yu X, Du Y, Cai C, Cai B, Zhu M, Xing C, Tan P, Lin M, Wu J, Li J, Wang M, Wang HY, Su XZ, Wang RF., Free PMC Article | 02/9/2019 |
| cFLIP appears to bind to IKKalpha to prevent IKKalpha from phosphorylating and activating IRF7. | Cellular FLIP long isoform (cFLIP(L))-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression.
Gates-Tanzer LT, Shisler JL., Free PMC Article | 12/1/2018 |