| Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment. | Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment.
Tokumaru S, Yamamoto Y, Yoshizawa K, Soejima Y, Sanjo H, Taki S. | 05/13/2023 |
| IRF2 is required for development and functional maturation of human NK cells. | IRF2 is required for development and functional maturation of human NK cells.
Persyn E, Wahlen S, Kiekens L, Van Loocke W, Siwe H, Van Ammel E, De Vos Z, Van Nieuwerburgh F, Matthys P, Taghon T, Vandekerckhove B, Van Vlierberghe P, Leclercq G., Free PMC Article | 01/11/2023 |
| IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer. | IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer.
Chen YJ, Luo SN, Wu H, Zhang NP, Dong L, Liu TT, Liang L, Shen XZ., Free PMC Article | 03/26/2022 |
| IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3. | IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.
Ren K, Zhu Y, Sun H, Li S, Duan X, Li S, Li Y, Li B, Chen L., Free PMC Article | 03/19/2022 |
| IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA. | IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.
Ye G, Wang P, Xie Z, Li J, Zheng G, Liu W, Cao Q, Li M, Cen S, Li Z, Yu W, Wu Y, Shen H., Free PMC Article | 02/12/2022 |
| Exosomes derived from human bone marrow mesenchymal stem cells transfer miR-222-3p to suppress acute myeloid leukemia cell proliferation by targeting IRF2/INPP4B. | Exosomes derived from human bone marrow mesenchymal stem cells transfer miR-222-3p to suppress acute myeloid leukemia cell proliferation by targeting IRF2/INPP4B.
Zhang F, Lu Y, Wang M, Zhu J, Li J, Zhang P, Yuan Y, Zhu F. | 06/12/2021 |
| IRF2-INPP4B axis inhibits apoptosis of acute myeloid leukaemia cells via regulating T helper 1/2 cell differentiation. | IRF2-INPP4B axis inhibits apoptosis of acute myeloid leukaemia cells via regulating T helper 1/2 cell differentiation.
Zhang F, Zhu K, Liu L, Zhu J, Li J, Zhang P, Hu Z, Yuan Y. | 05/22/2021 |
| Apolipoprotein L1 is transcriptionally regulated by SP1, IRF1 and IRF2 in hepatoma cells. | Apolipoprotein L1 is transcriptionally regulated by SP1, IRF1 and IRF2 in hepatoma cells.
Wang DP, Yu ZX, He ZC, Liao JF, Shen XB, Zhu PL, Chen WN, Lin X, Xu SH. | 05/15/2021 |
| ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway. | ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway.
Xiao XH, He SY. | 03/20/2021 |
| Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. | Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells.
Yan Y, Zheng L, Du Q, Yan B, Geller DA., Free PMC Article | 08/22/2020 |
| Results identified IRF2 as a target of miR-18a. Furthermore, H19 regulated IRF2 expression level through miR-18a. | Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR-18a-5p.
Zhang L, Deng X, Shi X, Dong X., Free PMC Article | 07/25/2020 |
| IRF-2 was involved in regulating the invasion and migration of gastric cancer cells and negatively regulates the expression of MMP-1. | IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1.
Chen YJ, Liang L, Li J, Wu H, Dong L, Liu TT, Shen XZ. | 07/18/2020 |
| IRF2 is a repressor of PD-L1. Thus, by downregulating a single nonessential gene, tumors become harder to see (reduced Ag presentation), more inhibitory (increased checkpoint inhibitor), and less susceptible to being killed by CD8(+) T cells. | Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression.
Kriegsman BA, Vangala P, Chen BJ, Meraner P, Brass AL, Garber M, Rock KL., Free PMC Article | 05/23/2020 |
| miR-664 was remarkably high in cutaneous squamous cell carcinomas (cSCC) patient specimens and cSCC cell lines. Study identified IRF2 as a direct downstream target of miR-664. Knockdown of IRF2 reverses pro-tumorigenesis phenotype of miR-664; whereas IRF2 over-expression inhibits miR-664 tumorigenesis in cSCC. Together, it revealed miR-664 functions as an oncogene in cSCC via suppression of IRF2. | MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon regulatory factor 2.
Li X, Zhou C, Zhang C, Xie X, Zhou Z, Zhou M, Chen L, Ding Z. | 04/4/2020 |
| Knockdown of IRF-1 reduces the stimulation of TRIM14 transcription by IFN-alpha, suggesting that IRF-1 is involved in the activation of TRIM14 by IFN-I. IRF-2 has little effect on IFN-alpha-induced TRIM14 transcription but is essential for the basal transcription of TRIM14. | TRIM14 expression is regulated by IRF-1 and IRF-2.
Cui J, Xu X, Li Y, Hu X, Xie Y, Tan J, Qiao W., Free PMC Article | 03/14/2020 |
| This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. | Interferon regulatory factor 1 inactivation in human cancer.
Alsamman K, El-Masry OS., Free PMC Article | 03/16/2019 |
| Data suggest that MIR1290 expression is remarkably upregulated in non-small-cell lung carcinoma tissues compared to adjacent normal lung tissues; IRF2 appears to be a direct target of MIR1290. (MIR1290 = microRNA-1290; IRF2 = interferon regulatory factor-2) | Overexpression of miR-1290 contributes to cell proliferation and invasion of non small cell lung cancer by targeting interferon regulatory factor 2.
Jin JJ, Liu YH, Si JM, Ni R, Wang J. | 11/3/2018 |
| These finding suggests that miR-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 and CXCR4, implicating its role in the inhibition of CRI in EC. | miR-302b inhibits cancer-related inflammation by targeting ERBB4, IRF2 and CXCR4 in esophageal cancer.
Zhang M, Zhang L, Cui M, Ye W, Zhang P, Zhou S, Wang J., Free PMC Article | 04/28/2018 |
| Our study primarily suggests IRF-2 as a potential prognostic biomarker in colorectal cancer | Prognostic value of IRF-2 expression in colorectal cancer.
Mei Z, Wang G, Liang Z, Cui A, Xu A, Liu Y, Liu C, Yang Y, Cui L., Free PMC Article | 04/21/2018 |
| The effects of IRF2 suppresses non-small cell lung cancer by promoting cell apoptosis, inhibiting cell proliferation and migration ability. | MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.
Liang C, Zhang X, Wang HM, Liu XM, Zhang XJ, Zheng B, Qian GR, Ma ZL., Free PMC Article | 02/3/2018 |
| In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1. Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection. | A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury.
Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR, TRIBE-AKI Consortium *., Free PMC Article | 08/12/2017 |
| Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2, OCI/AML-3, and THP-1 cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (AML) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B contributes to the effects of IRF2 on apoptosis and growth of AML cells. Thus, IRF2 serves as an important regulator in AML by targeting INPP4B. | IRF2-INPP4B axis participates in the development of acute myeloid leukemia by regulating cell growth and survival.
Zhang F, Zhu J, Li J, Zhu F, Zhang P. | 08/12/2017 |
| miR-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion. | Upregulation of microRNA-450 inhibits the progression of lung cancer in vitro and in vivo by targeting interferon regulatory factor 2.
Liu F, Yu X, Huang H, Chen X, Wang J, Zhang X, Lin Q. | 03/11/2017 |
| It might play as a tumor suppressor by regulating P53 signaling in gastric cancer. | MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients.
Chen YJ, Wu H, Zhu JM, Li XD, Luo SW, Dong L, Liu TT, Shen XZ. | 10/1/2016 |
| the association of IRF2 with susceptibility to systemic lupus erythematosus | Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.
Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Okamoto A, Kono H, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, Tsuchiya N., Free PMC Article | 12/19/2015 |