| Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis. | Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis.
Ghouri M, Ismail M, Zaidi SA, Rehman S, Dahani A, Saleem S, Zehra S., Free PMC Article | 07/30/2022 |
| IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses. | IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.
Shao S, Tsoi LC, Swindell WR, Chen J, Uppala R, Billi AC, Xing X, Zeng C, Sarkar MK, Wasikowski R, Jiang Y, Kirma J, Sun J, Plazyo O, Wang G, Harms PW, Voorhees JJ, Ward NL, Ma F, Pellegrini M, Merleev A, Perez White BE, Modlin RL, Andersen B, Maverakis E, Weidinger S, Kahlenberg JM, Gudjonsson JE., Free PMC Article | 12/18/2021 |
| The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling. | The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling.
Joshi H, Lunz B, Peters A, Zölch M, Berberich I, Berberich-Siebelt F. | 07/31/2021 |
| MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling. | MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
Moncrieffe MC, Bollschweiler D, Li B, Penczek PA, Hopkins L, Bryant CE, Klenerman D, Gay NJ., Free PMC Article | 05/1/2021 |
| IRAK2 is associated with systemic lupus erythematosus risk. | IRAK2 is associated with systemic lupus erythematosus risk.
Boumiza A, Zemni R, Sghiri R, Idriss N, Hassine HB, Chabchoub E, Mzabi A, Ghannouchi N, Bouajina E, Ben Hadj Slama F. | 11/21/2020 |
| Both IRAK2 and TLR10 play important roles in the onset and development of Hashimoto's disease. | IRAK2 and TLR10 confer risk of Hashimoto's disease: a genetic association study based on the Han Chinese population.
Li M, Han W, Zhu L, Jiang J, Qu W, Zhang L, Jia L, Zhou Q. | 12/7/2019 |
| these findings demonstrate a novel mechanism of interplays for the different branches of ER stress signaling network and highlight IRAK2 as a potential tumor suppressor to counterbalance oncogenic Smurf1. | IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
Liu J, Chen Y, Huang Q, Liu W, Ji X, Hu F, Zhu Y, Zhang L, Dong G. | 09/21/2019 |
| Authors identified IRAK2 rs779901 C > T as a predictor of NSCLC OS, with a variant-allele (T) attributed hazards ratio (HR) of 0.78 [95% confidence interval (CI) = 0.67-0.91, P = 0.001] in the PLCO dataset, 0.84 (0.72-0.98, 0.031) in the Harvard dataset, and 0.81 (0.73-0.90, 1.08x10(-4) ) in the meta-analysis of these two GWAS datasets. | Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.
Xu Y, Liu H, Liu S, Wang Y, Xie J, Stinchcombe TE, Su L, Zhang R, Christiani DC, Li W, Wei Q., Free PMC Article | 03/9/2019 |
| This study for the first time ever reports the association of IRAK2 rs3844283, IRAK2 rs708035, and the corresponding haplotypes with rheumatoid arthritis. | IRAK2 is associated with susceptibility to rheumatoid arthritis.
Hassine HB, Sghiri R, Chabchoub E, Boumiza A, Slama F, Baccouche K, Shakoor Z, Almogren A, Mariaselvam C, Tamouza R, Bouajina E, Zemni R. | 09/8/2018 |
| IRAK2 L392V showed intact binding to, but impaired ubiquitination of, tumor necrosis factor receptor-associated factor 6, a vital step in signal transduction | A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.
Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN, East-German and Swiss Hepatitis C Virus Study Groups. | 02/6/2016 |
| This for the first time implicates human IRAK2 in a human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point. | A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.
Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber ANR., Free PMC Article | 12/20/2014 |
| Human miR-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 target genes. | Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes.
Seol HS, Akiyama Y, Shimada S, Lee HJ, Kim TI, Chun SM, Singh SR, Jang SJ., Free PMC Article | 11/22/2014 |
| Results suggest that D431E-IRAK2 (interleukin-1 receptor-associated kinase-2) increases NF-kappaB activation by promoting TRAF6 ubiquitination by enhancing TNF Receptor-Associated Factor 6 (TRAF6)-IRAK2 interaction. | Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-κB activity through promoting TRAF6 ubiquitination.
Zhang W, He T, Wang Q, Li X, Wei J, Hou X, Zhang B, Huang L, Wang L., Free PMC Article | 08/9/2014 |
| These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 pathway. | Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling.
Benosman S, Ravanan P, Correa RG, Hou YC, Yu M, Gulen MF, Li X, Thomas J, Cuddy M, Matsuzawa Y, Sano R, Diaz P, Matsuzawa S, Reed JC., Free PMC Article | 01/11/2014 |
| Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha. | Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.
Flannery SM, Keating SE, Szymak J, Bowie AG., Free PMC Article | 09/10/2011 |
| analysis of differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease | Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease.
Cui JG, Li YY, Zhao Y, Bhattacharjee S, Lukiw WJ., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| Our data show that interleukin-1R-associated kinase 2 is a novel and critical component of TGFbeta signaling. | Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.
Mullenders J, Fabius AW, van Dongen MM, Kuiken HJ, Beijersbergen RL, Bernards R. | 07/19/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| the crystal structure of the MyD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs | Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Lin SC, Lo YC, Wu H., Free PMC Article | 06/28/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
Karasik D, Hsu YH, Zhou Y, Cupples LA, Kiel DP, Demissie S., Free PMC Article | 04/7/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Risk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |
| TRAF6 and interleukin receptor-associated kinase 2 are novel binding partners for PS1, and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage | Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.
Elzinga BM, Twomey C, Powell JC, Harte F, McCarthy JV. | 01/21/2010 |