| Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999. | Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999.
Sheng P, Li L, Li T, Wang Y, Hiers NM, Mejia JS, Sanchez JS, Zhou L, Xie M., Free PMC Article | 04/17/2023 |
| Age-Related Argonaute Loading of Ribosomal RNA Fragments. | Age-Related Argonaute Loading of Ribosomal RNA Fragments.
Guan L, Grigoriev A. | 05/15/2021 |
| Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila. | Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila.
Zaytseva O, Mitchell NC, Guo L, Marshall OJ, Parsons LM, Hannan RD, Levens DL, Quinn LM., Free PMC Article | 02/13/2021 |
| VCP Machinery Mediates Autophagic Degradation of Empty Argonaute. | VCP Machinery Mediates Autophagic Degradation of Empty Argonaute.
Kobayashi H, Shoji K, Kiyokawa K, Negishi L, Tomari Y. | 08/22/2020 |
| We chose Drosophila as a model system to take advantage of the presence of two biochemically distinct Argonautes, AGO1 and AGO2. Our results revealed AGO2 loading to be strongly favored by G-rich sequences. In contrast, AGO1 showed an enrichment of the 'GAC' motif in loaded species. | Hidden sequence specificity in loading of single-stranded RNAs onto Drosophila Argonautes.
Goh E, Okamura K., Free PMC Article | 10/12/2019 |
| Conserved association of Argonaute 1 and 2 proteins with miRNA and siRNA pathways throughout insect evolution, from cockroaches to flies. | Conserved association of Argonaute 1 and 2 proteins with miRNA and siRNA pathways throughout insect evolution, from cockroaches to flies.
Rubio M, Maestro JL, Piulachs MD, Belles X. | 11/24/2018 |
| findings propose that Ago-1 acts as a key regulator in controlling cell death, tumor regression and stress response in metazoan providing a constructive bridge between RNAi machinery and cell death | Two way controls of apoptotic regulators consign DmArgonaute-1 a better clasp on it.
Mondal T, Bag I, Sncvl P, Garikapati KR, Bhadra U, Pal Bhadra M., Free PMC Article | 02/24/2018 |
| Results suggest that Wisp interacts with Ago1 and induces miRNA adenylation and facilitates its downregulation. | Adenylation of maternally inherited microRNAs by Wispy.
Lee M, Choi Y, Kim K, Jin H, Lim J, Nguyen TA, Yang J, Jeong M, Giraldez AJ, Yang H, Patel DJ, Kim VN., Free PMC Article | 02/7/2015 |
| Results have established a novel role of Ago-1 as a regulator of the cell cycle. | Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis.
Pushpavalli SN, Sarkar A, Bag I, Hunt CR, Ramaiah MJ, Pandita TK, Bhadra U, Pal-Bhadra M., Free PMC Article | 03/29/2014 |
| AGO1 protein level is reduced in the absence of miRNA biogenesis & accumulates on depletion of GW182. Ectopic transcription of miRNAs within in vivo clones & genetic interference with the ubiquitin-proteasome system induced accumulation of AGO1. | Homeostatic control of Argonaute stability by microRNA availability.
Smibert P, Yang JS, Azzam G, Liu JL, Lai EC., Free PMC Article | 09/14/2013 |
| Smaug directly recruits Ago1 to nanos mRNA in a miRNA-independent manner, thereby repressing translation. | microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein.
Pinder BD, Smibert CA., Free PMC Article | 06/8/2013 |
| analysis of regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe | Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe.
Hur JK, Zinchenko MK, Djuranovic S, Green R., Free PMC Article | 05/18/2013 |
| The study provides a molecular explanation for the previously reported heterogeneity of miRNA 3' ends and proposes a model in which Nibbler converts miRNAs into isoforms that are compatible with the preferred length of Ago1-bound small RNAs. | The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1.
Han BW, Hung JH, Weng Z, Zamore PD, Ameres SL., Free PMC Article | 08/18/2012 |
| propose Drosophila Ago-1 as a multifunctional RNAi component that interconnects at least two unrelated events, chromatin organization in the nucleus and microRNA processing in the cytoplasm, which may be extended to the other systems | Drosophila Argonaute-1 is critical for transcriptional cosuppression and heterochromatin formation.
Pushpavalli SN, Bag I, Pal-Bhadra M, Bhadra U., Free PMC Article | 08/4/2012 |
| these results suggest that Ago1 and its miRNA biogenesis partners play a role in oocyte determination and germline cell division in Drosophila. | Drosophila Argonaute 1 and its miRNA biogenesis partners are required for oocyte formation and germline cell division.
Azzam G, Smibert P, Lai EC, Liu JL., Free PMC Article | 07/14/2012 |
| Ago1-RISC induces silencing via two independent pathways: shortening of the poly(A) tail and pure repression of translation | PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.
Fukaya T, Tomari Y., Free PMC Article | 02/4/2012 |
| Mutation of AGO2 or piwi increases silencing at piRNA clusters corresponding to an increase of HP1 association. | HP1 recruitment in the absence of argonaute proteins in Drosophila.
Moshkovich N, Lei EP., Free PMC Article | 05/3/2010 |
| Drosophila small RNAs are sorted between Ago1 and Ago2 according to their duplex structure and the identity of their first nucleotide. | Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway.
Ghildiyal M, Xu J, Seitz H, Weng Z, Zamore PD., Free PMC Article | 02/8/2010 |
| By inferring and validating hierarchical rules that predict differential AGO loading, data show that intrinsic determinants, including structural and thermodynamic properties of the duplex, regulate the fate of each RNA strand within the RNAi pathway. | Hierarchical rules for Argonaute loading in Drosophila.
Czech B, Zhou R, Erlich Y, Brennecke J, Binari R, Villalta C, Gordon A, Perrimon N, Hannon GJ., Free PMC Article | 01/21/2010 |
| Data revealed an active role for Watson-Crick base-pairing at positions 9 and 10 in promoting strand selection by AGO2, with little reciprocal effect on strand selection by AGO1. | Distinct mechanisms for microRNA strand selection by Drosophila Argonautes.
Okamura K, Liu N, Lai EC., Free PMC Article | 01/21/2010 |
| Ago2, but not Ago1, can activate translation of the target mRNAs when they lack the poly(A) tail.[review] | Argonaute-mediated translational repression (and activation).
Iwasaki S, Tomari Y. | 01/21/2010 |
| unwinding of miRNA-miRNA* duplexes is a passive process that does not require ATP or slicer activity of Ago1 | Structural determinants of miRNAs for RISC loading and slicer-independent unwinding.
Kawamata T, Seitz H, Tomari Y. | 01/21/2010 |
| Ago1-RISC (RNA-induced silencing complex) represses translation primarily by ATP-dependent shortening of the poly(A) tail of its mRNA targets. | Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression.
Iwasaki S, Kawamata T, Tomari Y. | 01/21/2010 |
| These observations indicate that sticky/citron kinase functions to regulate both actin-myosin-mediated cytokinesis and epigenetic gene silencing, linking cell-cycle progression to heterochromatin assembly and inheritance of gene expression states. | Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing.
Sweeney SJ, Campbell P, Bosco G., Free PMC Article | 01/21/2010 |
| AGO1-dependent microRNA pathway probably plays an instructive role in repressing germline stem cell differentiation. | Argonaute 1 regulates the fate of germline stem cells in Drosophila.
Yang L, Chen D, Duan R, Xia L, Wang J, Qurashi A, Jin P, Chen D. | 01/21/2010 |