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    Cyp6g1 Cytochrome P450 6g1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36316, updated on 17-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CYP6g1 role in the azinphos-methyl resistance

    Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster.
    Battlay P, Schmidt JM, Fournier-Level A, Robin C., Free PMC Article

    12/9/2017
    a combination of gene duplication, regulatory changes and protein coding changes has taken place at the Cyp6g1 locus during evolution and this locus may play a role in providing resistance to different environmental toxins in different Drosophila species

    Evolutionary changes in gene expression, coding sequence and copy-number at the Cyp6g1 locus contribute to resistance to multiple insecticides in Drosophila.
    Harrop TW, Sztal T, Lumb C, Good RT, Daborn PJ, Batterham P, Chung H., Free PMC Article

    09/13/2014
    We find that Imidacloprid does not induce expression of the analyzed Cyp6g1 and Cyp6a2 genes.

    Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line.
    Kalajdzic P, Markaki M, Oehler S, Savakis C.

    05/10/2014
    Recombinant D. melanogaster CYP6G1 exhibited p-nitroanisole O-dealkylation activity but was not active against eleven other typical P450 marker substrates.

    Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: purification, activity, and binding properties toward multiple pesticides.
    Cheesman MJ, Traylor MJ, Hilton ME, Richards KE, Taylor MC, Daborn PJ, Russell RJ, Gillam EM, Oakeshott JG.

    10/19/2013
    expression and tolerance to methylmercury during development

    Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development.
    Rand MD, Lowe JA, Mahapatra CT., Free PMC Article

    09/22/2012
    Resistance to nicotine or related plant allelochemicals is one of the beneficial phenotypes conferred by the Accord insertion allele of CYP6G1.

    Accord insertion in the 5' flanking region of CYP6G1 confers nicotine resistance in Drosophila melanogaster.
    Li X, Bai S, Cass BN.

    07/14/2012
    The induction response of the P450 gene Cyp6g1 to the xenobiotic phenobarbital requires the presence of both tissue specific enhancers and a distinct cis-regulatory element.

    Induction of a detoxification gene in Drosophila melanogaster requires an interaction between tissue specific enhancers and a novel cis-regulatory element.
    Chung H, Boey A, Lumb C, Willoughby L, Batterham P, Daborn PJ.

    01/14/2012
    The active site of Cyp6g1 can accommodate differently shaped substrates.

    Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance.
    Jones RT, Bakker SE, Stone D, Shuttleworth SN, Boundy S, McCart C, Daborn PJ, ffrench-Constant RH, van den Elsen JM.

    01/15/2011
    Cyp6g1 locus is a major contributor to Dichloro-Diphenyl-Trichloroethane resistance in field populations

    Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.
    Schmidt JM, Good RT, Appleton B, Sherrard J, Raymant GC, Bogwitz MR, Martin J, Daborn PJ, Goddard ME, Batterham P, Robin C., Free PMC Article

    10/4/2010
    Caffeine, DDT and phenobarbital fail to induce upstream DNAs of Cyp6g1.

    Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine.
    Morra R, Kuruganti S, Lam V, Lucchesi JC, Ganguly R.

    06/14/2010
    CYP6G1 is capable of metabolising at least two insecticides.

    Metabolism of imidacloprid and DDT by P450 CYP6G1 expressed in cell cultures of Nicotiana tabacum suggests detoxification of these insecticides in Cyp6g1-overexpressing strains of Drosophila melanogaster, leading to resistance.
    Joussen N, Heckel DG, Haas M, Schuphan I, Schmidt B.

    01/21/2010
    when levels of Cyp6g1 gene were manipulated in just the Malpighian tubules of adult Drosophila, the survival of the whole insect after 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) challenge was altered.

    A Drosophila systems approach to xenobiotic metabolism.
    Yang J, McCart C, Woods DJ, Terhzaz S, Greenwood KG, ffrench-Constant RH, Dow JA.

    01/21/2010
    Cis-regulatory elements in the accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1.

    Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1.
    Chung H, Bogwitz MR, McCart C, Andrianopoulos A, Ffrench-Constant RH, Batterham P, Daborn PJ., Free PMC Article

    01/21/2010
    results show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, Cyp6g1

    A single p450 allele associated with insecticide resistance in Drosophila.
    Daborn PJ, Yen JL, Bogwitz MR, Le Goff G, Feil E, Jeffers S, Tijet N, Perry T, Heckel D, Batterham P, Feyereisen R, Wilson TG, ffrench-Constant RH.

    01/21/2010
    Data show that Cyp6g1 itself may not have to be overexpressed for DDT resistance to occur.

    High expression of Cyp6g1, a cytochrome P450 gene, does not necessarily confer DDT resistance in Drosophila melanogaster.
    Kuruganti S, Lam V, Zhou X, Bennett G, Pittendrigh BR, Ganguly R.

    01/21/2010
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