| Dysregulation of Angiopoietin-like-4 Associated with Hyperlipidemia-induced Renal Injury by AMPK/ACC Pathway. | Dysregulation of Angiopoietin-like-4 Associated with Hyperlipidemia-induced Renal Injury by AMPK/ACC Pathway.
Qiu W, Huang L, Li Y, Liu Q, Lv Y. | 03/16/2023 |
| Increased expression of angiopoietin-like protein 4 regulates matrix metalloproteinase-13 expression in Porphyromonas gingivalis lipopolysaccharides-stimulated gingival fibroblasts and ligature-induced experimental periodontitis. | Increased expression of angiopoietin-like protein 4 regulates matrix metalloproteinase-13 expression in Porphyromonas gingivalis lipopolysaccharides-stimulated gingival fibroblasts and ligature-induced experimental periodontitis.
Kondo S, Kojima K, Nakamura N, Miyabe M, Kikuchi T, Ohno T, Sawada N, Minato T, Saiki T, Ito M, Sasajima S, Matsubara T, Mitani A, Naruse K. | 01/21/2023 |
| Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via beta1 Integrin/FAK signaling in diabetic nephropathy. | Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via β1 Integrin/FAK signaling in diabetic nephropathy.
Guo K, Pan P, Wu M, Ma Y, Lu J, Chen H. | 02/6/2021 |
| Calcineurin inhibitors ameliorate PAN-induced podocyte injury through the NFAT-Angptl4 pathway. | Calcineurin inhibitors ameliorate PAN-induced podocyte injury through the NFAT-Angptl4 pathway.
Shen X, Zhang Y, Lin C, Weng C, Wang Y, Feng S, Wang C, Shao X, Lin W, Li B, Wang H, Chen J, Jiang H. | 12/19/2020 |
| Tibet kefir milk decreases fat deposition by regulating the gut microbiota and gene expression of Lpl and Angptl4 in high fat diet-fed rats. | Tibet kefir milk decreases fat deposition by regulating the gut microbiota and gene expression of Lpl and Angptl4 in high fat diet-fed rats.
Gao J, Ding G, Li Q, Gong L, Huang J, Sang Y. | 09/26/2020 |
| The role of angiopoietin-like protein 4 in phenylephrine-induced cardiomyocyte hypertrophy. | The role of angiopoietin-like protein 4 in phenylephrine-induced cardiomyocyte hypertrophy.
Sun Y, Li Y, Liu C, Xue R, Dong B, Huang H, Peng L, Liu J, Dong Y., Free PMC Article | 09/12/2020 |
| ANGPTL4 partially modulates STAT3 and could serve as an effective diabetic retinopathy treatment strategy. | Angiopoietin-Like Protein 4 (ANGPTL4) Induces Retinal Pigment Epithelial Barrier Breakdown by Activating Signal Transducer and Activator of Transcription 3 (STAT3): Evidence from ARPE-19 Cells Under Hypoxic Condition and Diabetic Rats.
Yang X, Cao J, Du Y, Gong Q, Cheng Y, Su G., Free PMC Article | 02/15/2020 |
| this study represents the first investigation to demonstrate that Angptl4 can predict podocyte injury at earlier stages in minimal change disease | Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease.
Li JS, Chen X, Peng L, Wei SY, Zhao SL, Diao TT, He YX, Liu F, Wei QJ, Zhang QF, Li B., Free PMC Article | 05/21/2016 |
| GR and FoxO1 are required for Angptl4 transcription activation, and that FoxO1 negatively mediates the suppressive effect of insulin | Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.
Kuo T, Chen TC, Yan S, Foo F, Ching C, McQueen A, Wang JC., Free PMC Article | 12/20/2014 |
| the overexpression of Angptl4 exerts protective, anti-inflammatory and anti-angiogenic effects. It re-presents a novel therapeutic target gene for the treatment of acute lung injury induced by LPS. | Effect of angiopoietin-like protein 4 on rat pulmonary microvascular endothelial cells exposed to LPS.
Wang Y, Chen H, Li H, Zhang J, Gao Y., Free PMC Article | 05/17/2014 |
| Data suggest that endothelial lipoprotein lipase (LPL) levels in the heart are altered to maintain FA flux and may exploit angiopoietin-like protein-4 (ANGPTL4). | Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux.
Hauton D, Caldwell GM., Free PMC Article | 02/9/2013 |
| Angptl4 is a novel methylation-silenced gene both in rat and human mammary carcinomas. | Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas.
Hattori N, Okochi-Takada E, Kikuyama M, Wakabayashi M, Yamashita S, Ushijima T. | 08/27/2011 |
| ANGPTL4 is a direct GR target that participates in glucocorticoid-regulated triglyceride metabolism. | Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC., Free PMC Article | 01/21/2010 |
| There were significant upregulations of angiopoietin-like 4 (Angptl4) and heme oxygenase 1 (Hmox1) and downregulation of notch gene homolog 1 (notch1). | Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model.
Del Duca D, Wong G, Trieu P, Rodaros D, Kouremenos A, Tadevosyan A, Vaniotis G, Villeneuve LR, Tchervenkov CI, Nattel S, Allen BG, Hébert TE, Rohlicek CV. | 01/21/2010 |
| brain-derived adipokines could be involved in the acute pathology of traumatic brain injury partly through modulation of central inflammatory responses | Traumatic brain injury induces adipokine gene expression in rat brain.
Brown R, Thompson HJ, Imran SA, Ur E, Wilkinson M., Free PMC Article | 01/21/2010 |
| Angptl-4 is a fasting-induced controller of lipoprotein lipase in adipose tissue, acting extracellularly on the native conformation in an unusual fashion, like an unfolding molecular chaperone | Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue.
Sukonina V, Lookene A, Olivecrona T, Olivecrona G., Free PMC Article | 01/21/2010 |