| Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes. | Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes.
Elnagar A, El-Dawy K, El-Belbasi HI, Rehan IF, Embark H, Al-Amgad Z, Shanab O, Mickdam E, Batiha GE, Alamery S, Fouad SS, Cavalu S, Youssef M., Free PMC Article | 05/14/2022 |
| Cytosolic phosphoenolpyruvate carboxykinase is expressed in alpha-cells from human and murine pancreas. | Cytosolic phosphoenolpyruvate carboxykinase is expressed in α-cells from human and murine pancreas.
Westermeier F, Holyoak T, Gatica R, Martínez F, Negrón M, Yáñez AJ, Nahmias D, Nualart F, Burbulis I, Bertinat R. | 08/22/2020 |
| The relationship between PEPCK metabolism in the urinary tract and insulin resistance and diabetes is reported. | Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Sharma R, Kumari M, Prakash P, Gupta S, Tiwari S. | 07/18/2020 |
| PEPCK1 is integral to coordinating cellular metabolism in the liver and adipose tissue, although it does not directly effect hepatic glucose production or adipose glyceroneogenesis. | PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.
Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov VB, Church CD, Rodeheffer MS, Cline GW, Geisler JG, Bhanot S, Samuel VT., Free PMC Article | 02/1/2020 |
| Rap1 activation inhibits CNV through regulating barrier integrity and ROS generation of RPE in vivo, and selectively activating Rap1 may be a way to reduce vision loss from CNV | Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats.
Li J, Zhang R, Wang C, Wang X, Xu M, Ma J, Shang Q. | 05/25/2019 |
| Peroxynitrite-induced coronary vascular dysfunction may be mediated, at least in part, through increased expressions and activities of RhoA, ROCK1, and ROCK2. | RhoA/rock signaling mediates peroxynitrite-induced functional impairment of Rat coronary vessels.
Sun Z, Wu X, Li W, Peng H, Shen X, Ma L, Liu H, Li H., Free PMC Article | 06/24/2017 |
| GBS can reduce blood glucose in T2DM rats while improving glucose tolerance and hyperglycemia, and the mechanism appears to be associated with a decrease of hepatic PEPCK mRNA and protein expression. | Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus.
Wu J, Hou SS, Wang W, Yin M, Cheng N, Ge LL, Yin JJ, Xu J. | 09/17/2016 |
| PEPCK is downregulated and has a role in reduction of blood glucose and gluconeogenesis after phenobarbital administration in rats | Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats.
Oda H, Okuda Y, Yoshida Y, Kimura N, Kakinuma A. | 01/16/2016 |
| It observed lower expression of hepatic PEPCK mRNA, in the magnesium-deficient rats, thus suggesting a possible compensatory mechanism to diminish glycogenesis. A low-magnesium diet alters glucocorticoid metabolism, which leads to endothelial damage. | Down-regulation of hepatic phosphoenolpyruvate carboxykinase expression in magnesium-deficient rats.
Takaya J, Iharada A, Okihana H, Kaneko K. | 03/1/2014 |
| Leptin activates NOS III and induces nitric oxide that nitrates PEPCK-C to reduce its level and glyceroneogenesis. | Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release.
Jaubert AM, Penot G, Niang F, Durant S, Forest C., Free PMC Article | 01/12/2013 |
| The increase of protein intake during pregnancy could decrease the expression of y acid synthetase and PEPCK mRNA, and prevent offspring from high-fat diet-induced obesity in adult. | [Effects of expression of fatty acid synthetase and phosphoenolpyruvate carboxykinase in offspring rats by high protein intake in pregnancy].
Dong Y, Cui L, Zhang J, Sun Y. | 08/25/2012 |
| The expression of hepatic 11beta-HSD1 mRNA was upregulated, while hepatic phosphoenolpyruvate carboxykinase expression was downregulated in calcium-deficient rats. | Upregulation of hepatic 11β-hydroxysteroid dehydrogenase-1 expression in calcium-deficient rats.
Takaya J, Iharada A, Okihana H, Kaneko K. | 04/21/2012 |
| retinoic acid response element 2 in rat Pck1 promoter is responsible for transcriptional activation by retinoic acid | Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes.
Zhang Y, Li R, Chen W, Li Y, Chen G. | 12/10/2011 |
| The mRNA levels of one insulin-induced (Srebp-1c) and one insulin-suppressed (Pck1) genes in response to insulin, glucagon, and compactin treatments in hepatocytes were analyzed. | Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions.
Zhang Y, Chen W, Li R, Li Y, Ge Y, Chen G., Free PMC Article | 11/5/2011 |
| In addition to increased transcription rate, a gestational high fat diet resulted in modifications of the Pck1 histone code in livers of offspring. | Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats.
Strakovsky RS, Zhang X, Zhou D, Pan YX., Free PMC Article | 10/8/2011 |
| Pck1 plays an important role in both the mammary gland adipocytes and epithelial cells during lactation | Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells.
Hsieh CW, Huang C, Bederman I, Yang J, Beidelschies M, Hatzoglou M, Puchowicz M, Croniger CM., Free PMC Article | 10/8/2011 |
| Endoplasmic reticulum stress triggers suppression of AMPK while increasing C/EBPbeta and pCREB expression which activates PEPCK gene transcription. | C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE., Free PMC Article | 03/5/2011 |
| Calorie restriction can inhibit the expressions of FoxO1, PEPCK and G-6-P, strengthen insulin signal conduction, suppress gluconeogenesis and thus regulate glycometabolism. | [The effect of calorie restriction on the expression of liver's gluconeogenesis genes of rats fed a high fat diet].
Luo MJ, Chen LL, Zheng J, Zeng TS, Deng XL. | 08/9/2010 |
| During acute hepatic failure severe endotoxemia damages the function of gluconeogenesis in livers and kidneys by inhibiting transcription of PEPCK. | [The effect of endotoxemia on gluconeogenesis in livers and kidneys during acute hepatic failure].
Zhu YF, Tian DY, Xu D, Ni M, Song PH. | 07/12/2010 |
| Taken together, our results suggest that, during very demanding exercise, muscle-derived interleukin-6 could help increase hepatic glucose production by directly upregulating PEPCK mRNA abundance. | Control of gluconeogenic genes during intense/prolonged exercise: hormone-independent effect of muscle-derived IL-6 on hepatic tissue and PEPCK mRNA.
Banzet S, Koulmann N, Simler N, Sanchez H, Chapot R, Serrurier B, Peinnequin A, Bigard X. | 02/8/2010 |
| skeletal muscle PEPCK has a role in determining physical activity levels | Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK.
Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA., Free PMC Article | 01/21/2010 |
| structural data are consistent with a model in that the energy input from substrate association results in changes in the free energy landscape for the protein, allowing for structural transitions along an induced fit pathway | Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Sullivan SM, Holyoak T., Free PMC Article | 01/21/2010 |
| The effects of several variants of retinoic acid on the expression and activity of PEPCK in human, mouse, and rat adipose tissue are reported. | Retinoids upregulate phosphoenolpyruvate carboxykinase and glyceroneogenesis in human and rodent adipocytes.
Cadoudal T, Glorian M, Massias A, Fouque F, Forest C, Benelli C. | 01/21/2010 |
| Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level | Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level.
Zhang J. | 01/21/2010 |
| Comparison of the Mn2+-OAA-Mn2+GDP and Mn2+-Mn2+GTP structures illustrates a marked difference in the bound conformations of the nucleotide substrates in which the GTP nucleotide is bound in a high-energy state. | Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.
Sullivan SM, Holyoak T. | 01/21/2010 |