| TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs. | ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.
Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Houweling M, Vaandrager AB, Helms JB., Free PMC Article | 08/26/2017 |
| upregulation of Pnpla2 expression and activation of ATGL (due to an increase in ABHD5 and decrease in G0S2 levels), as well as a coordinated interplay of these genes with Lipe in mesenteric WAT, contribute, at least in part, to an increase in the concentration of circulating NEFA in rats with reduced fat mass. | Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tissue.
Dettlaff-Pokora A, Sledzinski T, Swierczynski J., Free PMC Article | 02/18/2017 |
| Report increased levels of ATGL and its inhibitor G0S2 following endurance training in metabolically different rat skeletal muscles. | Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles.
Turnbull PC, Longo AB, Ramos SV, Roy BD, Ward WE, Peters SJ., Free PMC Article | 05/7/2016 |
| PEDF and 44mer promote triglyceride degradation in cardiomyocytes after acute myocardial infarction via ATGL. | PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL.
Zhang H, Sun T, Jiang X, Yu H, Wang M, Wei T, Cui H, Zhuang W, Liu Z, Zhang Z, Dong H., Free PMC Article | 01/16/2016 |
| We conclude that PEDF-R mediates PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation. | PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R.
Wang X, Zhang Y, Lu P, Zhang H, Li Y, Dong H, Zhang Z. | 11/28/2015 |
| Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes, HSL and ATGL, in rat primary white adipocytes. | Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in rat primary white adipocytes.
Ogasawara J, Izawa T, Sakurai T, Shirato K, Ishibashi Y, Ohira Y, Ishida H, Ohno H, Kizaki T. | 10/3/2015 |
| These observations suggest that downregulation of ATGL causes the decreased PPARalpha activity which results in the imbalance of FA uptake and oxidation | Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides.
Gao H, Feng XJ, Li ZM, Li M, Gao S, He YH, Wang JJ, Zeng SY, Liu XP, Huang XY, Chen SR, Liu PQ. | 03/21/2015 |
| in skeletal muscle, during contraction-induced muscle lipolysis, ATGL and CGI-58 strongly associate and that the PLIN proteins work together to regulate lipolysis | Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction.
MacPherson RE, Ramos SV, Vandenboom R, Roy BD, Peters SJ., Free PMC Article | 06/8/2013 |
| Data suggest that fasting-induced up-regulation of adipose tissue ATGL is impaired in obesity and not improved by cold; ATGL expression is increased by cold but not by fasting, contributing to reduced lipolysis in obesity in increased energy demand. | Adipose triglyceride lipase expression and fasting regulation are differently affected by cold exposure in adipose tissues of lean and obese Zucker rats.
Caimari A, Oliver P, Palou A. | 01/26/2013 |
| We have mapped the epitope of the antibody that detects PEDF-R to the coding region of exon 4. | Identification of pigment epithelium-derived factor receptor (PEDF-R) antibody epitopes.
Subramanian P, Rapp M, Becerra SP., Free PMC Article | 04/14/2012 |
| To assess its role in insulin secretion, ATGL expression was decreased in INS832/13 cells (ATGL-knockdown (KD)) by small hairpin RNA. ATGL-KD increased the esterification of free fatty acids into triglycerides. | Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.
Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly É, Madiraju SRM, Poitout V, Prentki M., Free PMC Article | 01/21/2010 |