| IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency. | IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency.
Flores-Mendez M, Ohl L, Roule T, Zhou Y, Tintos-Hernández JA, Walsh K, Ortiz-González XR, Akizu N., Free PMC Article | 09/18/2024 |
| IMPDH2 suppression impedes cell proliferation by instigating cell cycle arrest and stimulates apoptosis in pediatric hepatoblastoma. | IMPDH2 suppression impedes cell proliferation by instigating cell cycle arrest and stimulates apoptosis in pediatric hepatoblastoma.
Li L, Wu Y, Huang HT, Yong JK, Lv Z, Zhou Y, Xiang X, Zhao J, Xi Z, Feng H, Xia Q., Free PMC Article | 09/10/2024 |
| Wnt/beta-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer. | Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
Huang Y, Chan S, Chen S, Liu X, Li M, Zheng L, Dong Z, Yang Z, Liu Z, Zhou D, Zhang X, Zhang B., Free PMC Article | 02/7/2024 |
| Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway. | Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway.
Gao G, Xue Q, He J, Wu M, Jiang Y, Li Q, Zhang Y, Shi W. | 11/30/2023 |
| Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM., Free PMC Article | 09/1/2023 |
| Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia. | Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia.
Chen PS, Wu MC, Tai CH, Chang YY, Lan MY, Chen YF, Lin HI, Lee NC, Lin CH. | 06/24/2023 |
| Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population. | Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population.
Lin J, Li C, Cui Y, Hou Y, Zhang L, Ou R, Wei Q, Liu K, Yang T, Xiao Y, Jiang Q, Zhao B, Yang J, Chen X, Shang H. | 03/21/2023 |
| c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming. | c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.
Zhang Q, Cui K, Yang X, He Q, Yu J, Yang L, Yao G, Guo W, Luo Z, Liu Y, Chen Y, He Z, Lan P., Free PMC Article | 02/11/2023 |
| SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-kappaB signaling. | SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling.
Li TW, Kenney AD, Park JG, Fiches GN, Liu H, Zhou D, Biswas A, Zhao W, Que J, Santoso N, Martinez-Sobrido L, Yount JS, Zhu J., Free PMC Article | 10/15/2022 |
| Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation. | Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation.
A Wahab N, D Dardar H, Yunus R, M Zainudin Z, M Mokhtar N. | 05/7/2022 |
| IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder. | IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder.
Kuukasjärvi A, Landoni JC, Kaukonen J, Juhakoski M, Auranen M, Torkkeli T, Velagapudi V, Suomalainen A., Free PMC Article | 03/26/2022 |
| Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer. | Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.
Wang S, Chao F, Zhang C, Han D, Xu G, Chen G. | 01/8/2022 |
| IMPDH2 and HPRT expression and a prognostic significance in preoperative and postoperative patients with osteosarcoma. | IMPDH2 and HPRT expression and a prognostic significance in preoperative and postoperative patients with osteosarcoma.
Chaiyawat P, Phanphaisarn A, Sirikaew N, Klangjorhor J, Thepbundit V, Teeyakasem P, Phinyo P, Pruksakorn D, Settakorn J., Free PMC Article | 11/6/2021 |
| The expression and prognostic role of IMPDH2 in ovarian cancer. | The expression and prognostic role of IMPDH2 in ovarian cancer.
Tian Y, Zhang J, Chen L, Zhang X. | 06/12/2021 |
| Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.
Johnson MC, Kollman JM., Free PMC Article | 04/24/2021 |
| Genetic variants in the glucocorticoid pathway genes and birth weight. | Genetic variants in the glucocorticoid pathway genes and birth weight.
Schneider MO, Hübner T, Pretscher J, Goecke TW, Schwitulla J, Häberle L, Kornhuber J, Ekici AB, Beckmann MW, Fasching PA, Schwenke E. | 03/20/2021 |
| that upregulation of IMPDH2 is a prerequisite for the occurance of aberrant nucleolar function and increased anabolic processes in glioblastoma | IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.
Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT., Free PMC Article | 11/23/2019 |
| association of T/C and C/C genotypes in the SNP rs11706052 (IMPDH2) with the occurrence of rejection episodes considering only patients who received immunosuppressive drug mycophenolate mofetil associated with cyclosporine or tacrolimus and corticoids, demonstrated association with a protection against rejection 15.6-fold | Polymorphisms in IMPDH2, UGT2B7, and CES2 genes influence the risk of graft rejection in kidney transplant recipients taking mycophenolate mofetil.
Cilião HL, Camargo-Godoy RBO, Souza MF, Zanuto A, Delfino VDA, Cólus IMS. | 06/15/2019 |
| Study verified that overexpressing IMPDH2 could promote G1/S phase cell cycle transition through activation of PI3K/AKT/mTOR and PI3K/AKT/FOXO1 pathways and facilitate cell invasion, migration and EMT by regulating PI3K/AKT/mTOR pathway. | IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways.
Duan S, Huang W, Liu X, Liu X, Chen N, Xu Q, Hu Y, Song W, Zhou J., Free PMC Article | 02/16/2019 |
| Our study demonstrates IMPDH2 may be served as an independent prognostic biomarker for NPC patients, in which high IMPDH expression suggests poor prognosis of NPC patients. | High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma.
Xu Y, Zheng Z, Gao Y, Duan S, Chen C, Rong J, Wang K, Yun M, Weng H, Ye S, Zhang J., Free PMC Article | 09/1/2018 |
| inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an intracellular target of the PPIA-Sanglifehrin A binary complex. | IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex.
Pua KH, Stiles DT, Sowa ME, Verdine GL. | 11/25/2017 |
| Rod and ring formation might be an adaptive homeostatic mechanism, allowing IMPDH to sense changes in the one-carbon folate pathway. | 'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.
Calise SJ, Purich DL, Nguyen T, Saleem DA, Krueger C, Yin JD, Chan EK. | 08/5/2017 |
| Taking together, these results indicate that natural product myricetin exhibits potent anti-leukemia activity by interfering with purine nucleotides biosynthetic pathway through the suppression of hIMPDH1/2 catalytic activity. | Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity.
Pan H, Hu Q, Wang J, Liu Z, Wu D, Lu W, Huang J. | 05/20/2017 |
| The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases | Elevated expression of IMPDH2 is associated with progression of kidney and bladder cancer.
Zou J, Han Z, Zhou L, Cai C, Luo H, Huang Y, Liang Y, He H, Jiang F, Wang C, Zhong W. | 01/30/2016 |
| IMPDH2 is directly involved in the development of chemoresistance and radioresistance in osteosarcoma cells. | IMPDH2 mediate radioresistance and chemoresistance in osteosarcoma cells.
Li HX, Meng QP, Liu W, Li YG, Zhang HM, Bao FC, Song LL, Li HJ. | 09/12/2015 |