| Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila. | Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila.
Tikhonova E, Revel-Muroz A, Georgiev P, Maksimenko O., Free PMC Article | 03/14/2024 |
| Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless. | Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless.
Jagtap PKA, Müller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J. | 01/5/2024 |
| [Diversity of MLE Helicase Functions in the Regulation of Gene Expression in Higher Eukaryotes]. | [Diversity of MLE Helicase Functions in the Regulation of Gene Expression in Higher Eukaryotes].
Nikolenko JV, Georgieva SG, Kopytova DV. | 04/4/2023 |
| MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes. | MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes.
Nikolenko JV, Kurshakova MM, Krasnov AN, Georgieva SG. | 07/24/2021 |
| ENY2 Protein Interacts with RNA Helicase MLE | Multifunctional ENY2 Protein Interacts with RNA Helicase MLE.
Nikolenko JV, Kurshakova MM, Krasnov AN. | 05/16/2020 |
| Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless has been reported. | Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless.
Ankush Jagtap PK, Müller M, Masiewicz P, von Bülow S, Hollmann NM, Chen PC, Simon B, Thomae AW, Becker PB, Hennig J., Free PMC Article | 11/30/2019 |
| our research provides structural insights into the interactions between MLE dsRBDs and R2H1 and facilitates a deeper understanding of the mechanism by which MLE tandem dsRBDs play an indispensable role in specific recognition of roX and the assembly of the MSL-DCC in Drosophila dosage compensation. | Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.
Lv M, Yao Y, Li F, Xu L, Yang L, Gong Q, Xu YZ, Shi Y, Fan YJ, Tang Y., Free PMC Article | 10/12/2019 |
| We have employed a systems biology approach (microarray) to investigate the global aneuploid effect of the maleless (mle) mutation that disrupts the binding of male specific lethal (MSL) proteins that function in dosage compensation. | Drosophila maleless gene counteracts X global aneuploid effects in males.
Bhadra U, Gandhi SG, Palaparthi R, Balyan MK, Pal-Bhadra M. | 07/1/2017 |
| MLE specifically targets hairpin RNAs at their site of transcription. The association of MLE at these sites is independent of sequence and chromosome location | The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts.
Cugusi S, Li Y, Jin P, Lucchesi JC., Free PMC Article | 05/14/2016 |
| The Drosophila Helicase MLE is Implicated in Functions Distinct From its Role in Dosage Compensation | The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation.
Cugusi S, Kallappagoudar S, Ling H, Lucchesi JC., Free PMC Article | 03/5/2016 |
| Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. | Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling.
Prabu JR, Müller M, Thomae AW, Schüssler S, Bonneau F, Becker PB, Conti E. | 02/13/2016 |
| UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. | UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation.
Militti C, Maenner S, Becker PB, Gebauer F. | 02/6/2016 |
| Study reports that mle (napts) mutant flies exhibit developmental lethality, decreased fecundity and increased neurodegeneration. | Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging.
Garber G, Smith LA, Reenan RA, Rogina B., Free PMC Article | 08/18/2012 |
| the minimal transactivation domain of MLE mediates the expression of MLE target genes through recruitment of Pol II | MLE activates transcription via the minimal transactivation domain in Drosophila.
Aratani S, Kageyama Y, Nakamura A, Fujita H, Fujii R, Nishioka K, Nakajima T. | 01/21/2010 |
| the ATPase activity is sufficient for MLE's role in transcriptional enhancement, while the helicase activity is necessary for the spreading of the complex along the X chromosome | The MLE subunit of the Drosophila MSL complex uses its ATPase activity for dosage compensation and its helicase activity for targeting.
Morra R, Smith ER, Yokoyama R, Lucchesi JC., Free PMC Article | 01/21/2010 |
| A maleless structure-function analysis clarified the domain requirements for RNA interaction, helicase activity and localization to the X chromosomal territory. | Structure-function analysis of the RNA helicase maleless.
Izzo A, Regnard C, Morales V, Kremmer E, Becker PB., Free PMC Article | 01/21/2010 |
| Zn72D is required for productive splicing of the transcript for the MSL protein Maleless, explaining the dosage compensation defect. | Zinc finger protein Zn72D promotes productive splicing of the maleless transcript.
Worringer KA, Panning B., Free PMC Article | 01/21/2010 |
| Data suggest that MLE can stimulate the transcription activity of rox2 and that MLE associates with rox2 through direct interaction with a newly identified 54-bp repeat, Prox. | MLE functions as a transcriptional regulator of the roX2 gene.
Lee CG, Reichman TW, Baik T, Mathews MB. | 01/21/2010 |
| The roX1 and roX2 genes produce redundant, male-specific lethal transcripts required for targeting the MSL complex. | The roX genes encode redundant male-specific lethal transcripts required for targeting of the MSL complex.
Meller VH, Rattner BP., Free PMC Article | 01/21/2010 |