| this study demonstrates, that Lok kinase activation is required for the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and might also offer novel insight into how DNA damage causes tissue aging and cancer formation. | DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation.
Ma X, Han Y, Song X, Do T, Yang Z, Ni J, Xie T. | 09/16/2017 |
| FHA domain in Mnk plays dual functions in mediating embryonic DNA damage responses by means of its phosphopeptide-binding ability: activating Mnk in nucleus upon DNA damage &recruiting Mnk to multiple subcellular structures independently of DNA damage | The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.
Takada S, Collins ER, Kurahashi K., Free PMC Article | 02/13/2016 |
| We conclude that the primary responsibility for maintaining genome integrity in the male germline lies with Chk2, and that P53 is required to reconstitute the germline when cells are eliminated owing to unrepaired DNA damage. | Chk2 and p53 regulate the transmission of healed chromosomes in the Drosophila male germline.
Titen SW, Lin HC, Bhandari J, Golic KG., Free PMC Article | 12/20/2014 |
| nuclear retention involves Chk2-mediated inactivation of the Drosophila stem loop binding protein (SLBP), the levels of which are specifically depleted in damaged nuclei following Chk2 phosphorylation, an event that contributes to nuclear fallout. | Developmentally regulated elimination of damaged nuclei involves a Chk2-dependent mechanism of mRNA nuclear retention.
Iampietro C, Bergalet J, Wang X, Cody NA, Chin A, Lefebvre FA, Douziech M, Krause HM, Lécuyer E. | 08/9/2014 |
| MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis. | Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.
Pushpavalli SN, Sarkar A, Ramaiah MJ, Chowdhury DR, Bhadra U, Pal-Bhadra M., Free PMC Article | 08/3/2013 |
| while Chk2 functions by activating the p53-dependent apoptotic cascade, Chk2 also functions independently of p53 to limit survival. | Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss.
Kurzhals RL, Titen SW, Xie HB, Golic KG., Free PMC Article | 10/1/2011 |
| Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. | Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis.
Bakhrat A, Pritchett T, Peretz G, McCall K, Abdu U., Free PMC Article | 03/12/2011 |
| The DNA damage-activated kinases Chk1 and Chk2 may be involved in tau phosphorylation and toxicity in the pathogenesis of Alzheimer's disease. | A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.
Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K., Free PMC Article | 07/26/2010 |
| Data propose that hid expression is activated in a pole cell-specific manner by loki/p53 and dpp/egr during embryogenesis. | Expression of the apoptosis inducer gene head involution defective in primordial germ cells of the Drosophila embryo requires eiger, p53, and loki function.
Maezawa T, Arita K, Shigenobu S, Kobayashi S. | 01/21/2010 |
| Genetic screening was performed to identify novel components of the Chk2 signaling pathway in Drosophila. | Genetic screen for genes involved in Chk2 signaling in Drosophila.
Park SY, Song YH. | 01/21/2010 |
| regulates irradiation-induced, p53-mediated apoptosis in Drosophila | Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
Peters M, DeLuca C, Hirao A, Stambolic V, Potter J, Zhou L, Liepa J, Snow B, Arya S, Wong J, Bouchard D, Binari R, Manoukian AS, Mak TW., Free PMC Article | 01/21/2010 |
| Dmnk plays an important role in a mitotic checkpoint in syncytial embryos. | Drosophila chk2 plays an important role in a mitotic checkpoint in syncytial embryos.
Xu J, Du W. | 01/21/2010 |
| Drosophila has Chk2- and p53-independent pathways to activate caspases and induce apoptosis in response to IR. | Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster.
Wichmann A, Jaklevic B, Su TT., Free PMC Article | 01/21/2010 |
| in flies, chk2 is involved in monitoring double-strand breaks (DSBs) caused by irradiation during S and G2 phases | The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2.
Masrouha N, Yang L, Hijal S, Larochelle S, Suter B., Free PMC Article | 01/21/2010 |
| plays a crucial role in the DNA damage response pathway mediating cell cycle arrest and apoptosis, and the ATM-Chk2 pathway is likely conserved in Drosophila | Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis.
Xu J, Xin S, Du W. | 01/21/2010 |
| Mutations in the ATR/Chk2 DNA damage signal transduction pathway dramatically suppress these axis specification defects, but do not restore retrotransposon or Stellate silencing. | Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.
Klattenhoff C, Bratu DP, McGinnis-Schultz N, Koppetsch BS, Cook HA, Theurkauf WE. | 01/21/2010 |
| Grp/DChk1, and not Dmnk/DChk2, is the main effector kinase involved in G(2)/M checkpoint control in Drosophila cells | Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable.
de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC., Free PMC Article | 01/21/2010 |
| mutation in the Drosophila Chk2 homolog (DmChk2/Mnk) suppresses the defects in the translation of gurken mRNA and also the defects in oocyte nuclear morphology | Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk.
Abdu U, Brodsky M, Schüpbach T. | 01/21/2010 |
| The mnk (also known as loki) gene encodes Checkpoint kinase 2 (Chk2), which functions in DNA-damage signal transduction. | grp (chk1) replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition.
Takada S, Kwak S, Koppetsch BS, Theurkauf WE. | 01/21/2010 |