| Role of BicDR in bristle shaft construction and support of BicD functions. | Role of BicDR in bristle shaft construction and support of BicD functions.
Jejina A, Ayala Y, Beuchle D, Höhener T, Dörig RE, Vazquez-Pianzola P, Hernández G, Suter B., Free PMC Article | 02/8/2024 |
| Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility. | Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility.
Cui H, Ali MY, Goyal P, Zhang K, Loh JY, Trybus KM, Solmaz SR., Free PMC Article | 04/13/2021 |
| the RNA is required for robust activation of dynein motility. We show that a cis-acting RNA localisation signal promotes the interaction of Egl with BicD, which licenses the latter protein to recruit dynein and dynactin. Our data support a model for BicD activation based on RNA-induced occupancy of two Egl-binding sites on the BicD dimer. | RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs.
McClintock MA, Dix CI, Johnson CM, McLaughlin SH, Maizels RJ, Hoang HT, Bullock SL., Free PMC Article | 03/30/2019 |
| artificially dimerized Egl activates dynein-dynactin-BicD in the absence of mRNA. The ability of mRNA cargo to orchestrate the activation of the mRNP (messenger ribonucleotide protein) complex is an elegant way to ensure that only cargo-bound motors are motile. | Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex.
Sladewski TE, Billington N, Ali MY, Bookwalter CS, Lu H, Krementsova EB, Schroer TA, Trybus KM., Free PMC Article | 03/30/2019 |
| To study the pathological consequences of BICD2 mutations in vivo, and to address the controversial debate whether two of these mutations are neuron or muscle specific, we generated the first Drosophila model of spinal muscular atrophy-2. | Novel insights into SMALED2: BICD2 mutations increase microtubule stability and cause defects in axonal and NMJ development.
Martinez Carrera LA, Gabriel E, Donohoe CD, Hölker I, Mariappan A, Storbeck M, Uhlirova M, Gopalakrishnan J, Wirth B. | 02/16/2019 |
| Bic-D is also required to transport Chc mRNA into the oocyte and for transport and proper localization of Chc protein to the oocyte cortex. | Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D.
Vazquez-Pianzola P, Adam J, Haldemann D, Hain D, Urlaub H, Suter B. | 06/14/2014 |
| 2.2 A resolution crystal structure of a cargo-binding region of the dynein adaptor Bicaudal-D (BicD), which reveals a parallel coiled-coil homodimer | Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.
Liu Y, Salter HK, Holding AN, Johnson CM, Stephens E, Lukavsky PJ, Walshaw J, Bullock SL., Free PMC Article | 08/31/2013 |
| Results implicate BicD as a new player in clathrin-associated trafficking processes and show a novel requirement for microtubule-based motor transport in the synaptic vesicle cycle. | Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
Li X, Kuromi H, Briggs L, Green DB, Rocha JJ, Sweeney ST, Bullock SL., Free PMC Article | 05/31/2010 |
| while BicD might contribute to recruitment of dynein to the cargo it is not absolutely required for such dynein localization | BicaudalD actively regulates microtubule motor activity in lipid droplet transport.
Larsen KS, Xu J, Cermelli S, Shu Z, Gross SP., Free PMC Article | 01/21/2010 |
| We propose that Msn functions together with Bic-D to regulate the apical localization of dynein in generating directed nuclear migration within differentiating R-cell precursor cells. | The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye.
Houalla T, Hien Vuong D, Ruan W, Suter B, Rao Y. | 01/21/2010 |
| component of a selective dynein motor complex that drives transcript localization in a variety of tissues | Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis.
Bullock SL, Ish-Horowicz D. | 01/21/2010 |
| Through the combined actions of the fusome, MT, and Baz, Par-1 is selectively enriched and localized within the oocyte, where, in conjunction with BicD, Egalitarian (Egl), and Dynein, it acts on the MT cytoskeleton to effect polarization. | The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein.
Vaccari T, Ephrussi A. | 01/21/2010 |
| Various processes in which BicD is involved during embryogenesis (review) | BicD-dependent localization processes: from Drosophilia development to human cell biology.
Claussen M, Suter B. | 01/21/2010 |