| Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts. | Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
Kizhedathu A, Chhajed P, Yeramala L, Sain Basu D, Mukherjee T, Vinothkumar KR, Guha A., Free PMC Article | 01/22/2022 |
| Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts. | Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.
Kizhedathu A, Kunnappallil RS, Bagul AV, Verma P, Guha A., Free PMC Article | 03/20/2021 |
| The authors propose that ATR/Chk1 negatively regulate G2-M in developing tracheoblasts and that G2 arrest facilitates cellular and hypertrophic organ growth. | Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila.
Kizhedathu A, Bagul AV, Guha A., Free PMC Article | 06/1/2019 |
| Grp was assumed to play a direct role in the immune response in D. melanogaster. | [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome].
Makhnovskii PA, Kuzmin IV, Nefedova LN, Kima AI. | 01/28/2017 |
| The Grp gene is expressed at the adult stage of D. melanogaster in gender-specific and tissue-specific manner. | Domesticated retroviral GAG gene in Drosophila: new functions for an old gene.
Nefedova LN, Kuzmin IV, Makhnovskii PA, Kim AI. | 05/3/2014 |
| Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1). | Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
Fasulo B, Koyama C, Yu KR, Homola EM, Hsieh TS, Campbell SD, Sullivan W., Free PMC Article | 08/4/2012 |
| The Grp gene has been demonstrated to be a functional gene in the D. melanogaster genome, bit its function is yet to be determined. | [Translational analysis of the Grp gene, a genomic homologue of the Gag gene of the gypsy retrotransposon of Drosophila melanogaster].
Kuz'min IV, Shnyriaeva AA, Nefedova LN, Kim AI. | 12/17/2011 |
| the Grp gene is not a pseudogene, but it is a functional gene of the D. melanogaster genome whose role remains to be elucidated. | [Transcriptional analysis of the Grp gene, a genomic homolog of the retrotransposon gypsy gag gene, in Drosophila melanogaster].
Nefedova LN, Kuz'min IV, Burmistrova DA, Rezazadekh S, Kim AI. | 10/29/2011 |
| A genetic screen identified grapes, the gene that encodes the Drosophila orthologue of checkpoint kinase 1 (CHK1). Knockdown of grapes by RNAi rescued eye development despite ongoing PERK activation. | Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.
Malzer E, Daly ML, Moloney A, Sendall TJ, Thomas SE, Ryder E, Ryoo HD, Crowther DC, Lomas DA, Marciniak SJ., Free PMC Article | 02/26/2011 |
| The Grp gene product has a highly conserved structure in different species of the Drosophilidae family and is under stabilizing selection, which suggests its important genomic function in Drosophila. | [Molecular evolution of mobile elements of the gypsy group: a homolog of the gag gene in Drosophila].
Nefedova LN, Kim AI. | 01/21/2010 |
| Grp(Chk1) prevents nuclear CDK1 activation by delaying CycB nuclear accumulation through Wee1-dependent and independent mechanisms. | Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation.
Royou A, McCusker D, Kellogg DR, Sullivan W., Free PMC Article | 01/21/2010 |
| Grp/DChk1, and not Dmnk/DChk2, is the main effector kinase involved in G(2)/M checkpoint control in Drosophila cells | Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable.
de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC., Free PMC Article | 01/21/2010 |
| Embryos mutant for grp, which encodes Chk1, are DNA-replication-checkpoint defective and fail to cellularize, gastrulate or to initiate high-level zygotic transcription at the midblastula transition. | grp (chk1) replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition.
Takada S, Kwak S, Koppetsch BS, Theurkauf WE. | 01/21/2010 |