| AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells. | AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells.
Iida Y, Osaki M, Sato S, Izutsu R, Seong H, Komatsu H, Taniguchi F, Okada F. | 08/28/2024 |
| AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma. | AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma.
Chen S, Du W, Feng K, Liu K, Li C, Li S, Yin H., Free PMC Article | 02/6/2024 |
| AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer. | AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.
Chen LK, Lin SP, Xie YH, Tan XP, Xiong BH, Zeng XF, Zhu CR, Cao SY, Ye XY, Liu HJ, Wu XP., Free PMC Article | 08/19/2023 |
| Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells. | Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
Izutsu R, Osaki M, Jehung JP, Seong HK, Okada F. | 10/29/2022 |
| The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients. | The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
Goto K, Morimoto M, Osaki M, Tanio A, Izutsu R, Fujiwara Y, Okada F., Free PMC Article | 04/16/2022 |
| AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells. | AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
Izutsu R, Osaki M, Nemoto H, Jingu M, Sasaki R, Yoshioka Y, Ochiya T, Okada F., Free PMC Article | 03/5/2022 |
| In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation. | In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation.
Liu Y, Yang J, Shi Z, Tan X, Jin N, O'Brien C, Ott C, Grisoli A, Lee E, Volk K, Conroy M, Franz E, Bryant A, Campbell L, Crowley B, Grisoli S, Alexandrou AT, Li C, Harper EI, Asem M, Johnson J, Leonard A, Santanello K, Klein A, Wang Q, Zhang S, Hilliard TS, Stack MS., Free PMC Article | 08/7/2021 |
| AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer. | AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer.
Nakamura S, Kanda M, Shimizu D, Tanaka C, Inokawa Y, Hattori N, Hayashi M, Yamada S, Nakayama G, Omae K, Koike M, Kodera Y. | 12/19/2020 |
| Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells. | Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
Kanda Y, Osaki M, Onuma K, Sonoda A, Kobayashi M, Hamada J, Nicolson GL, Ochiya T, Okada F., Free PMC Article | 11/10/2018 |
| this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. | Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene.
Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E., Free PMC Article | 12/2/2017 |
| AMIGO2 is an important regulator of the PDK1-Akt pathway. | AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.
Park H, Lee S, Shrestha P, Kim J, Park JA, Ko Y, Ban YH, Park DY, Ha SJ, Koh GY, Hong VS, Mochizuki N, Kim YM, Lee W, Kwon YG., Free PMC Article | 02/13/2016 |
| Stable expression of a DEGA/AMIGO-2 antisense construct led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice. | DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity.
Rabenau KE, O'Toole JM, Bassi R, Kotanides H, Witte L, Ludwig DL, Pereira DS. | 01/21/2010 |
| Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. | Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.
Ono T, Sekino-Suzuki N, Kikkawa Y, Yonekawa H, Kawashima S., Free PMC Article | 01/21/2010 |