| Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight muscles. | Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight muscles.
Nikonova E, DeCata J, Canela M, Barz C, Esser A, Bouterwek J, Roy A, Gensler H, Heß M, Straub T, Forne I, Spletter ML., Free PMC Article | 06/25/2024 |
| Results identify a novel regulatory circuit in drosophila, with Bru restricting the activity of osk, and osk in turn restricting the activity of Bru. | oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.
Kanke M, Jambor H, Reich J, Marches B, Gstir R, Ryu YH, Ephrussi A, Macdonald PM., Free PMC Article | 08/8/2015 |
| Here we describe an in vivo assay system to monitor the spatial pattern of Bru-dependent repression, separate from the full complexity of osk regulation. | Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.
Kim G, Pai CI, Sato K, Person MD, Nakamura A, Macdonald PM., Free PMC Article | 07/25/2015 |
| Aret potently promotes flight muscle splicing patterns when ectopically expressed in Drosophila jump muscles. | Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila.
Oas ST, Bryantsev AL, Cripps RM., Free PMC Article | 11/29/2014 |
| A role for Bruno in Enok-controlled GSC maintenance | The Drosophila putative histone acetyltransferase Enok maintains female germline stem cells through regulating Bruno and the niche.
Xin T, Xuan T, Tan J, Li M, Zhao G, Li M. | 02/1/2014 |
| Multiple RNA binding domains of Bruno confer recognition of diverse binding sites for translational repression.( | Multiple RNA binding domains of Bruno confer recognition of diverse binding sites for translational repression.
Reveal B, Garcia C, Ellington A, Macdonald PM., Free PMC Article | 09/1/2012 |
| Bruno RNA recognition motif contains four antiparallel beta-strands and two alpha-helices. | Bruno protein contains an expanded RNA recognition motif.
Lyon AM, Reveal BS, Macdonald PM, Hoffman DW., Free PMC Article | 01/21/2010 |
| Repression by Bruno during oogenesis is required to restrict Gcl expression in the early embryo. | Bruno negatively regulates germ cell-less expression in a BRE-independent manner.
Moore J, Han H, Lasko P. | 01/21/2010 |
| Bruno shuttles between the nucleus and cytoplasm, and may first bind oskar mRNA in the nucleus. | Two distinct domains of Bruno bind specifically to the oskar mRNA.
Snee M, Benz D, Jen J, Macdonald PM. | 01/21/2010 |
| Ectopic expression of bruno prolongs oskar repression and blocks posterior body patterning. | A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.
Snee MJ, Harrison D, Yan N, Macdonald PM. | 01/21/2010 |
| we show that Bruno binds specifically to the gurken 3'UTR and the dorso-ventral defects caused by Bruno over-expression are due to a reduction of Gurken levels in the oocyte, Bruno plays similar roles in translational regulation of gurken and oskar. | Bruno regulates gurken during Drosophila oogenesis.
Filardo P, Ephrussi A. | 01/21/2010 |
| Sxl transcript represents a novel target of Bruno-mediated translational repression required for cystoblast differentiation. | Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis.
Wang Z, Lin H., Free PMC Article | 01/21/2010 |
| Arrest mutants have significantly reduced levels of Delta protein at the interface of germline and follicle cells. | Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta.
Yan N, Macdonald PM., Free PMC Article | 01/21/2010 |
| Prior to reaching the posterior pole of the oocyte, oskar mRNA is translationally silenced by Bruno binding to the 3' untranslated region. | Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.
Chekulaeva M, Hentze MW, Ephrussi A. | 01/21/2010 |
| Oskar has a role in stabilization of polar granule components, while Bruno and nuage facilitate post transcriptional regulation by promoting the formation or reorganization of RNA-protein complexes | Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components.
Snee MJ, Macdonald PM. | 01/21/2010 |