| Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome. | Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome.
Tamberg L, Jaago M, Säälik K, Sirp A, Tuvikene J, Shubina A, Kiir CS, Nurm K, Sepp M, Timmusk T, Palgi M., Free PMC Article | 08/28/2021 |
| provides initial insights into the mechanisms underlying the function of daughterless and Emc in neurons while providing a novel understanding of how Emc functions to restrict daughterless activity within the cell | Extramacrochaetae promotes branch and bouton number via the sequestration of daughterless in the cytoplasm of neurons.
Waddell EA, Viveiros JM, Robinson EL, Sharoni MA, Latcheva NK, Marenda DR. | 05/16/2020 |
| Daughterless level sets Emc protein levels in most cells, apparently by stabilizing Emc in heterodimers. Emc is destabilized in proneural regions by local competition for heterodimer formation by proneural bHLH proteins including Atonal or AS-C proteins. | Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners.
Li K, Baker NE., Free PMC Article | 06/1/2019 |
| Suppression of da by wild-type emc was essential for cell chirality formation and for normal left-right asymmetric development of the embryonic hindgut. | E and ID proteins regulate cell chirality and left-right asymmetric development in Drosophila.
Ishibashi T, Hatori R, Maeda R, Nakamura M, Taguchi T, Matsuyama Y, Matsuno K. | 04/20/2019 |
| Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation in part by restricting the expression of the cell adhesion molecule Neurexin. | Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.
D'Rozario M, Zhang T, Waddell EA, Zhang Y, Sahin C, Sharoni M, Hu T, Nayal M, Kutty K, Liebl F, Hu W, Marenda DR., Free PMC Article | 12/31/2016 |
| Notch signaling activates the expression of extramacrochaetae (emc), which encodes a helix-loop-helix (HLH) transcription factor. Emc, in turn, then forms a biochemical complex with Da. | Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.
Spratford CM, Kumar JP., Free PMC Article | 08/15/2015 |
| Data show that bHLHb22 protein daughterless (Da) binding alters the turnover parameters of bHLHc28 protein scute (Sc). | bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability.
Kiparaki M, Zarifi I, Delidakis C., Free PMC Article | 06/27/2015 |
| We explain this paradox by demonstrating that Da induces the differentiation factor Prospero (Pros) whose asymmetric segregation is essential for differentiation in one of the two daughter cells. | A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells.
Yasugi T, Fischer A, Jiang Y, Reichert H, Knoblich JA., Free PMC Article | 06/20/2015 |
| we show that during the development of epithelial cells in the imaginal discs, the G2/M transition, and hence cell proliferation, is controlled by Emc via Da. In eukaryotic cells, the main activator of this transition is the Cdc25 phosphatase, string | The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string.
Andrade-Zapata I, Baonza A., Free PMC Article | 11/29/2014 |
| Da transactivation domains play essential roles in neurogenesis and in E(spl)-mediated repression. | Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression.
Zarifi I, Kiparaki M, Koumbanakis KA, Giagtzoglou N, Zacharioudaki E, Alexiadis A, Livadaras I, Delidakis C., Free PMC Article | 01/5/2013 |
| lilli contributes to ato auto-regulation in the morphogenetic furrow by first regulating the expression of da prior to ato. | Drosophila lilliputian is required for proneural gene expression in retinal development.
Distefano GM, Gangemi AJ, Khandelwal PJ, Saunders AJ, Marenda DR., Free PMC Article | 07/21/2012 |
| Study shows that the Drosophila class I factor Daughterless (Da) is upregulated by Hedgehog (Hh) and Decapentaplegic (Dpp) signalling during retinal neurogenesis. | Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye.
Lim J, Jafar-Nejad H, Hsu YC, Choi KW., Free PMC Article | 01/21/2010 |
| Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis. | Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis.
Wong MC, Castanon I, Baylies MK., Free PMC Article | 01/21/2010 |
| Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless. | Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless.
Cadigan KM, Jou AD, Nusse R. | 01/21/2010 |
| Da confers neuronal identity to epithelial cells in the wing margin. | Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin.
Jafar-Nejad H, Tien AC, Acar M, Bellen HJ. | 01/21/2010 |
| The expression of Dap was found to be controlled by the epidermal growth factor receptor signaling-regulated transcription factor Pointed (Pnt) and the proneural basic helix-loop-helix proteins Atonal (Ato) and Daughterless (Da). | Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development.
Sukhanova MJ, Deb DK, Gordon GM, Matakatsu MT, Du W., Free PMC Article | 01/21/2010 |
| coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila | Daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila.
Smith JE 3rd, Cummings CA, Cronmiller C. | 01/21/2010 |