| Chemical shift assignments of dsRBD1 and linker region of R2D2, a siRNA binding protein in the Drosophila RNAi pathway. | Chemical shift assignments of dsRBD1 and linker region of R2D2, a siRNA binding protein in the Drosophila RNAi pathway.
Aute R, Deshmukh MV. | 11/8/2023 |
| Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers. | Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.
Deng T, Su S, Yuan X, He J, Huang Y, Ma J, Wang J., Free PMC Article | 08/30/2023 |
| Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
Yamaguchi S, Naganuma M, Nishizawa T, Kusakizako T, Tomari Y, Nishimasu H, Nureki O., Free PMC Article | 07/23/2022 |
| Partial reconstitution of the RNAi response in human cells has been demonstrated using Drosophila gene products, DCR-2, Loqs-PD, and R2D2. | Partial reconstitution of the RNAi response in human cells using Drosophila gene products.
Kennedy EM, Kornepati AV, Bogerd HP, Cullen BR., Free PMC Article | 09/9/2017 |
| R2D2 and Loqs-PD have partially overlapping function. | Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.
Mirkovic-Hösle M, Förstemann K., Free PMC Article | 09/20/2014 |
| R2D2 controls endo-siRNA sorting by localizing Dcr-2, and presumably endo-siRNA duplexes, to cytoplasmic foci. | Roles of R2D2, a cytoplasmic D2 body component, in the endogenous siRNA pathway in Drosophila.
Nishida KM, Miyoshi K, Ogino A, Miyoshi T, Siomi H, Siomi MC. | 04/20/2013 |
| Propose that the Dicer-2 helicase domain uses ATP to generate many siRNAs from a single molecule of dsRNA and that phosphate and R2D2 restrict substrate specificity. | Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.
Cenik ES, Fukunaga R, Lu G, Dutcher R, Wang Y, Tanaka Hall TM, Zamore PD., Free PMC Article | 06/18/2011 |
| direct role for the R2D2/Dcr-2 heterodimer in sensing central mismatch positions that direct miRNA* strands to AGO2 | R2D2 organizes small regulatory RNA pathways in Drosophila.
Okamura K, Robine N, Liu Y, Liu Q, Lai EC., Free PMC Article | 03/5/2011 |
| Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila, with R2D2 essential for the loading of siRNAs into effector Ago-RISC complexes. | Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila.
Marques JT, Kim K, Wu PH, Alleyne TM, Jafari N, Carthew RW., Free PMC Article | 03/8/2010 |
| r2d2(1) mutants have reduced viability and defective female fertility that stems from abnormal follicle cell function, and Dicer-1 impacts this process | Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.
Kalidas S, Sanders C, Ye X, Strauss T, Kuhn M, Liu Q, Smith DP., Free PMC Article | 01/21/2010 |
| R2D2 is both a protein sensor for small interfering RNA (siRNA) thermodynamic asymmetry and a licensing factor RNA interference pathway | A protein sensor for siRNA asymmetry.
Tomari Y, Matranga C, Haley B, Martinez N, Zamore PD. | 01/21/2010 |
| results indicate that R2D2 bridges the initiation and effector steps of the Drosophila RNAi pathway by facilitating small interfering RNA (siRNA) passage from Dicer to RNA-initiated silencing complex (RISC) | R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway.
Liu Q, Rand TA, Kalidas S, Du F, Kim HE, Smith DP, Wang X. | 01/21/2010 |