| Reduced Expression of CLEC4G in Neurons Is Associated with Alzheimer's Disease. | Reduced Expression of CLEC4G in Neurons Is Associated with Alzheimer's Disease.
Feng X, Qi F, Huang Y, Zhang G, Deng W., Free PMC Article | 05/31/2024 |
| C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis. | C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis.
Chen X, Li S, Jiang ZM, Gu M, Feng B, Xie ZQ, Huang MY, Chen Z, Tang ML. | 08/28/2023 |
| Macrophage-specific ablation of LSECtin in breast cancer cells decreased cancer stem cell frequency and tumor growth. Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 monoclonal antibodies has a therapeutic effect on breast cancer. | LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3.
Liu D, Lu Q, Wang X, Wang J, Lu N, Jiang Z, Hao X, Li J, Liu J, Cao P, Peng G, Tao Y, Zhao D, He F, Tang L., Free PMC Article | 07/18/2020 |
| Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin. | Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.
Shimojima M, Takenouchi A, Shimoda H, Kimura N, Maeda K., Free PMC Article | 03/21/2015 |
| The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation. | Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver.
Zuo Y, Ren S, Wang M, Liu B, Yang J, Kuai X, Lin C, Zhao D, Tang L, He F. | 09/14/2013 |
| The mobility of LSECtin-carbohydrate recognition domain increased after addition of Ca(2+) and N-acetylglucosamine. | Mobility study of individual residue sites in the carbohydrate recognition domain of LSECtin using SDSL-EPR technique.
Wang C, Yang J, Zhou Y, Cong J, Dong G, Hu X, Tang L, Wu K. | 12/22/2012 |
| Axl,Tyro3,DC-SIGN and LSECtin are identified as new virus receptors for Lassa virus cell entry. | Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.
Shimojima M, Ströher U, Ebihara H, Feldmann H, Kawaoka Y., Free PMC Article | 03/24/2012 |
| The human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcbeta1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction. | Mouse LSECtin as a model for a human Ebola virus receptor.
Pipirou Z, Powlesland AS, Steffen I, Pöhlmann S, Taylor ME, Drickamer K., Free PMC Article | 09/24/2011 |
| The interaction between CD44 & LSECtin is dependent on protein-glycan recognition. CD44 is the 1st identified endogenous ligand of LSECtin, & similarly, LSECtin is a novel ligand of CD44. | The DC-SIGN family member LSECtin is a novel ligand of CD44 on activated T cells.
Tang L, Yang J, Tang X, Ying W, Qian X, He F. | 05/31/2010 |
| Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response. | Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.
Tang L, Yang J, Liu W, Tang X, Chen J, Zhao D, Wang M, Xu F, Lu Y, Liu B, Sun Q, Zhang L, He F., Free PMC Article | 01/21/2010 |
| LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. | The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1.
Domínguez-Soto A, Aragoneses-Fenoll L, Gómez-Aguado F, Corcuera MT, Clária J, García-Monzón C, Bustos M, Corbí AL., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Li H, Tang NL, Chan PK, Wang CY, Hui DS, Luk C, Kwok R, Huang W, Sung JJ, Kong QP, Zhang YP. | 09/10/2008 |
| Our results reveal important differences between Ebola virus and HIV-1 capture by DC-SIGN/R and LSECtin and hint towards different biological functions of these lectins. | Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding.
Gramberg T, Soilleux E, Fisch T, Lalor PF, Hofmann H, Wheeldon S, Cotterill A, Wegele A, Winkler T, Adams DH, Pöhlmann S., Free PMC Article | 01/21/2010 |
| LSECtin is a pathogen-associated molecular pattern receptor in human myeloid cells; results suggest that LSECtin participates in antigen uptake and internalization | The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.
Dominguez-Soto A, Aragoneses-Fenoll L, Martin-Gayo E, Martinez-Prats L, Colmenares M, Naranjo-Gomez M, Borras FE, Munoz P, Zubiaur M, Toribio ML, Delgado R, Corbi AL. | 01/21/2010 |
| results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor | Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.
Liu W, Tang L, Zhang G, Wei H, Cui Y, Guo L, Gou Z, Chen X, Jiang D, Zhu Y, Kang G, He F. | 01/21/2010 |