| Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5. | Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
Vanden Brink H, Vandeputte D, Brito IL, Ronnekleiv OK, Roberson MS, Lomniczi A., Free PMC Article | 09/30/2024 |
| The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome. | The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
Zhan K, Wu H, Xu Y, Rao K, Zheng H, Qin S, Yang Y, Jia R, Chen W, Huang S., Free PMC Article | 03/20/2024 |
| TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. | TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats.
Liang H, Matei N, McBride DW, Xu Y, Zhou Z, Tang J, Luo B, Zhang JH., Free PMC Article | 09/11/2021 |
| Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding. | Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding.
Zhou H, Zhou SY, Gillilland M 3rd, Li JY, Lee A, Gao J, Zhang G, Xu X, Owyang C., Free PMC Article | 05/22/2021 |
| Satiety induced by bile acids is mediated via vagal afferent pathways. | Satiety induced by bile acids is mediated via vagal afferent pathways.
Wu X, Li JY, Lee A, Lu YX, Zhou SY, Owyang C., Free PMC Article | 05/22/2021 |
| Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury. | Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury.
Han M, Li S, Xie H, Liu Q, Wang A, Hu S, Zhao X, Kong Y, Wang W, Li C. | 03/28/2021 |
| Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3beta mediated inflammation and mitochondrial pathway. | Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway.
Li J, Cheng R, Wan H., Free PMC Article | 03/20/2021 |
| Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5. | Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5.
Trammell SAJ, Svenningsen JS, Holst JJ, Gillum MP, Kuhre RE., Free PMC Article | 02/13/2021 |
| Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats. | Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats.
Liang H, Matei N, McBride DW, Xu Y, Tang J, Luo B, Zhang JH., Free PMC Article | 10/24/2020 |
| expression in intestine decreased during progression of glucose intolerance | The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance.
Yan X, Li P, Tang Z, Feng B., Free PMC Article | 07/14/2018 |
| TGR5 activation reduced ICAM-1, TGF-beta1 and FN expressions induced by high glucose in glomerular mesangial cells, the mechanism might be through suppressing S1P/S1P2 signaling, thus ameliorating diabetic nephropathy. | TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells.
Yang Z, Xiong F, Wang Y, Gong W, Huang J, Chen C, Liu P, Huang H. | 12/30/2017 |
| contributes to hepatic cystogenesis by increasing cAMP and enhancing cholangiocyte proliferation | TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.
Masyuk TV, Masyuk AI, Lorenzo Pisarello M, Howard BN, Huang BQ, Lee PY, Fung X, Sergienko E, Ardecky RJ, Chung TDY, Pinkerton AB, LaRusso NF., Free PMC Article | 10/7/2017 |
| GPBAR1/TGR5 receptor agonist, tauroursodeoxycholic acid, has anti-inflammatory effects in microglial cells. | TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells.
Yanguas-Casás N, Barreda-Manso MA, Nieto-Sampedro M, Romero-Ramírez L. | 08/12/2017 |
| In high glucose-treated glomerular mesangial cells, TGR5 can suppress the NF-kappaB-mediated upregulation of fibronectin and TGF-beta1 by inhibiting RhoA/ROCK signaling via protein kinase A. | TGR5 suppresses high glucose-induced upregulation of fibronectin and transforming growth factor-β1 in rat glomerular mesangial cells by inhibiting RhoA/ROCK signaling.
Xiong F, Li X, Yang Z, Wang Y, Gong W, Huang J, Chen C, Liu P, Huang H. | 07/22/2017 |
| bile acids promote intestinal epithelial cell proliferation and decrease mucosal injury by upregulating TGR5 expression in obstructive jaundice. | Bile acid receptor TGR5 overexpression is associated with decreased intestinal mucosal injury and epithelial cell proliferation in obstructive jaundice.
Ji CG, Xie XL, Yin J, Qi W, Chen L, Bai Y, Wang N, Zhao DQ, Jiang XY, Jiang HQ. | 07/1/2017 |
| We conclude that increased levels of circulatory bile acids induced by high-fat feeding upregulate nNOS and TGR5 expression in the gastric myenteric plexus, resulting in enhanced NANC relaxation and delayed gastric emptying. | Upregulation of bile acid receptor TGR5 and nNOS in gastric myenteric plexus is responsible for delayed gastric emptying after chronic high-fat feeding in rats.
Zhou H, Zhou S, Gao J, Zhang G, Lu Y, Owyang C., Free PMC Article | 07/25/2015 |
| Data suggest that Tgr5 is expressed in two cell types of term placenta, macrophages and trophoblasts; Tgr5 mRNA abundance in placenta markedly increases during the last week of pregnancy in control but not in model of maternal cholestasis. | Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term.
Keitel V, Spomer L, Marin JJ, Williamson C, Geenes V, Kubitz R, Häussinger D, Macias RI. | 03/15/2014 |
| A new role is demonstrated for TGR5 on epithelial cells, where the bile acid receptor regulates colonic fluid and electrolyte transport, decreases basal secretory tone and inhibits cholinergic-induced secretory responses. | The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon.
Ward JB, Mroz MS, Keely SJ. | 03/8/2014 |
| biliary drainage affects expression of inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats | Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats.
Wang ZK, Xiao JG, Huang XF, Gong YC, Li W., Free PMC Article | 01/11/2014 |
| TGR5 is localized in the plasma membrane of isolated Kupffer cells and is responsive to bile acids;it may play a protective role in obstructive cholestasis preventing excessive cytokine production thereby reducing liver injury. | Expression and function of the bile acid receptor TGR5 in Kupffer cells.
Keitel V, Donner M, Winandy S, Kubitz R, Häussinger D. | 01/21/2010 |
| TGR5 is implicated in the suppression of macrophage functions by bile acids | A G protein-coupled receptor responsive to bile acids.
Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M. | 01/21/2010 |
| This is the first report on the expression of TGR5 in sinusoidal endothelial cells. Regulation of eNOS by TGR5 connects bile salts with hepatic hemodynamics. | The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.
Keitel V, Reinehr R, Gatsios P, Rupprecht C, Görg B, Selbach O, Häussinger D, Kubitz R. | 01/21/2010 |