| Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila. | Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
Li B, Li S, Zheng H, Yan Z., Free PMC Article | 01/1/2022 |
| analysis reveals an ultrastructural pattern of NompC that is structurally and mechanically optimized for the sensory functions of campaniform mechanoreceptors. | Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors.
Sun L, Gao Y, He J, Cui L, Meissner J, Verbavatz JM, Li B, Feng X, Liang X., Free PMC Article | 05/25/2019 |
| Drosophila food texture preference requires NOMPC, a TRP-family mechanosensory channel. NOMPC localizes to the sensory dendrites of neurons housed within gustatory sensilla, and is essential for their mechanosensory-evoked responses. | A mechanosensory receptor required for food texture detection in Drosophila.
Sánchez-Alcañiz JA, Zappia G, Marion-Poll F, Benton R., Free PMC Article | 12/22/2018 |
| de novo atomic structure of Drosophila NOMPC determined by single-particle electron cryo-microscopy | Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y., Free PMC Article | 11/18/2017 |
| Study provides evidence that Ankyrin repeats are essential for NOMPC mechanogating; further mechanogating of NOMPC requires the integrity of microtubules associated to the plasma membrane, providing a precedent for a tethered mechanism for mechanotransduction channel activation. | Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.
Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN., Free PMC Article | 12/19/2015 |
| NOMPC is required for establishing the fine structure of the sensory dendritic compartment. | NOMPC-dependent mechanotransduction shapes the dendrite of proprioceptive neurons.
Chadha A, Kaneko M, Cook B. | 10/24/2015 |
| NOMPC is likely to be a crucial component of mechanotransducers that accounts for mechanotransductions in mechanosensory neurons of Drosophila. | NOMPC is likely a key component of Drosophila mechanotransduction channels.
Gong J, Wang Q, Wang Z. | 01/18/2014 |
| This study provides strong evidence that the ankyrin-repeat domains of the transient receptor potential channel NOMPC structurally contribute to the membrane-microtubule connecting filaments in Drosophila. | A NOMPC-dependent membrane-microtubule connector is a candidate for the gating spring in fly mechanoreceptors.
Liang X, Madrid J, Gärtner R, Verbavatz JM, Schiklenk C, Wilsch-Bräuninger M, Bogdanova A, Stenger F, Voigt A, Howard J. | 11/30/2013 |
| The transient receptor potential channels NOMPC, NANCHUNG, and INACTIVE, but not the dmPIEZO channel, are implicated in mechanotransduction and/or signal amplification for the detection of sound by the larval Cho neurons. | Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
Zhang W, Yan Z, Jan LY, Jan YN., Free PMC Article | 11/16/2013 |
| Ripped Pocket (rpk), No Mechanoreceptor Potential C (nompC), and NMDA Receptors 1 and 2 (Nmdars) play critical roles in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia. | Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae.
Tsubouchi A, Caldwell JC, Tracey WD., Free PMC Article | 05/11/2013 |
| identification of NOMPC (No mechanoreceptor potential C), a member of the transient receptor potential (TRP) family of ion channels, as a mechanotransduction channel for gentle touch | Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation.
Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN., Free PMC Article | 03/2/2013 |
| We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost | Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1.
Effertz T, Nadrowski B, Piepenbrock D, Albert JT, Göpfert MC. | 11/17/2012 |
| Drosophila sound receptors require NompC for mechanical signal detection and amplification, demonstrating the importance of this transient receptor potential channel for hearing and reviving the idea that the fly's auditory transducer might be NompC | NompC TRP channel is essential for Drosophila sound receptor function.
Effertz T, Wiek R, Göpfert MC. | 12/17/2011 |
| NompC mediates proprioception in locomotion and has a role as a mechanosensitive channel. | The role of the TRP channel NompC in Drosophila larval and adult locomotion.
Cheng LE, Song W, Looger LL, Jan LY, Jan YN., Free PMC Article | 09/6/2010 |
| results provide a strong evidence for NOMPC as a primary transduction channel in Drosophila mechansensory organs | Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia.
Lee J, Moon S, Cha Y, Chung YD., Free PMC Article | 09/6/2010 |