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    HTR6 5-hydroxytryptamine receptor 6 [ Homo sapiens (human) ]

    Gene ID: 3362, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension.

    Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension.
    Chechekhin VI, Ivanova AM, Kulebyakin KY, Antropova YG, Karagyaur MN, Skryabina MN, Chechekhina ES, Basalova NA, Grigorieva OA, Sysoeva VY, Kalinina NI, Tkachuk VA, Tyurin-Kuzmin PA.

    01/17/2024
    Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment.

    Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment.
    Zhang W, Li L, Li J, Yu H, Zheng F, Yan B, Cai W, Chen Y, Yin L, Tang D, Xu Y, Dai Y., Free PMC Article

    04/16/2022
    [5-HT6 receptor-mTOR: An hyperactive couple in neuropathic pain].", trans "Recepteur 5-HT6 et mTOR - Un couple hyperactif dans la douleur neuropathique.

    [5-HT(6) receptor-mTOR: An hyperactive couple in neuropathic pain].
    Doly S, Martin PY, Courteix C.

    01/29/2022
    Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors.

    Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors.
    Wang Q, Dong X, Hu T, Qu C, Lu J, Zhou Y, Li J, Pei G., Free PMC Article

    12/4/2021
    HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.

    HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
    Barbeito P, Tachibana Y, Martin-Morales R, Moreno P, Mykytyn K, Kobayashi T, Garcia-Gonzalo FR., Free PMC Article

    09/18/2021
    Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P.

    Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P.
    Courault P, Emery S, Bouvard S, Liger F, Chauveau F, Meyronet D, Fourier A, Billard T, Zimmer L, Lancelot S.

    05/15/2021
    Correlation of 5-HTR6 gene polymorphism with vestibular migraine.

    Correlation of 5-HTR6 gene polymorphism with vestibular migraine.
    Wu X, Qiu F, Wang Z, Liu B, Qi X., Free PMC Article

    12/19/2020
    Serotonin 6 receptor has a role in Alzheimer's disease and depression

    Serotonin 6 receptor controls Alzheimer's disease and depression.
    Yun HM, Park KR, Kim EC, Kim S, Hong JT., Free PMC Article

    08/27/2016
    that HTR6 plays an important role in modulating seizure activity and that the blockade of the 5-HT6 receptor/mTOR pathway could be a potential therapeutic target for epilepsy treatment

    5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.
    Wang L, Lv Y, Deng W, Peng X, Xiao Z, Xi Z, Chen G, Wang X.

    03/12/2016
    Studies indicate that serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in Alzheimer's disease (AD).

    Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.
    Benhamú B, Martín-Fontecha M, Vázquez-Villa H, Pardo L, López-Rodríguez ML.

    12/6/2014
    [review] Controlling the activity of 5-HTR6 receptors seems to provide benefits by alleviating cognitive impairments.

    Improving the treatment of schizophrenia: role of 5-HT receptors in modulating cognitive and extrapyramidal motor functions.
    Shimizu S, Mizuguchi Y, Ohno Y.

    05/10/2014
    Data indicate that hydrogen-bond formation of a methoxy or hydroxy group is not important for binding at the 5-HT6 receptor.

    Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
    Mattsson C, Svensson P, Boettcher H, Sonesson C.

    11/30/2013
    The human cloned 5-HT6 receptor is stably transfected in HeLa cells.

    1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands.
    Bernotas R, Lenicek S, Antane S, Zhang GM, Smith D, Coupet J, Harrison B, Schechter LE.

    08/27/2013
    When expressed in pyramidal neuron progenitors, serotonin receptor 5-HT6 transgene decreases the migration speed of cortical pyramidal neurons, thereby affecting a fundamental step in the assembly of neural circuits.

    Excess of serotonin affects neocortical pyramidal neuron migration.
    Riccio O, Jacobshagen M, Golding B, Vutskits L, Jabaudon D, Hornung JP, Dayer AG., Free PMC Article

    04/6/2013
    These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control.

    5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
    Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJ, Dekeyne A, Séveno M, Rivet JM, Gaven F, Déléris P, Hervé D, Fone KC, Bockaert J, Millan MJ, Marin P., Free PMC Article

    03/2/2013
    There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6.

    An association study of the genetic polymorphisms in 13 neural plasticity-related genes with semantic and episodic memories.
    Gong P, Zheng Z, Chi W, Lei X, Wu X, Chen D, Zhang K, Zheng A, Gao X, Zhang F.

    09/15/2012
    present findings showed the presence of a higher density of 5-HT(6) receptors, as labeled by [(125)I]SB-258585, in striatum than in hippocampus and prefrontal cortex, and specifically within the neuronal body

    Distribution of serotonin receptor of type 6 (5-HT₆) in human brain post-mortem. A pharmacology, autoradiography and immunohistochemistry study.
    Marazziti D, Baroni S, Pirone A, Giannaccini G, Betti L, Schmid L, Vatteroni E, Palego L, Borsini F, Bordi F, Piano I, Gargini C, Castagna M, Catena-Dell'osso M, Lucacchini A.

    08/25/2012
    results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.

    Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis.
    Kishi T, Fukuo Y, Okochi T, Kawashima K, Kitajima T, Inada T, Ozaki N, Musso GM, Kane JM, Correll CU, Iwata N.

    06/30/2012
    [review] Since discovery of the 5-HT6 receptor and development of its small-molecule ligands, neurochemical and localization studies have clearly demonstrated its central role in modulating GABAergic neurotransmission across brain structures and networks.

    The central role of 5-HT6 receptors in modulating brain neurochemistry.
    Dawson LA.

    01/7/2012
    detected association between 2 markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis respectively. HTR6 may play important role in pathophysiology of METH-induced psychosis in Japanese

    Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population.
    Kishi T, Fukuo Y, Okochi T, Kitajima T, Kawashima K, Naitoh H, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N.

    07/2/2011
    Common variants in the gene for HT6R do not contribute to obesity.

    Common variants in the gene for the serotonin receptor 6 (HTR6) do not contribute to obesity.
    Peeters AV, Beckers S, Verrijken A, Roevens P, Peeters PJ, Van Gaal LF, Van Hul W.

    04/23/2011
    we found no association involving HTR6 polymorphism and mood disorder in the Japanese population

    Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis.
    Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N, Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N.

    09/20/2010
    Observational study and meta-analysis of gene-disease association. (HuGE Navigator)

    Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis.
    Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N, Fukuo Y, Kishi T, Yoshimura R, Kitajima T, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Iwata N.

    06/30/2010
    Data show that analogues of 5-cyclic amine-3-arylsulfonylindazoles have been identified as high-affinity 5-HT(6) receptor ligands.

    5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.
    Haydar SN, Yun H, Andrae PM, Mattes J, Zhang J, Kramer A, Smith DL, Huselton C, Graf R, Aschmies S, Schechter LE, Comery TA, Robichaud AJ.

    05/10/2010
    Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain

    Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.
    Yun HM, Baik JH, Kang I, Jin C, Rhim H., Free PMC Article

    05/3/2010
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