| Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition. | Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Li T, Wei L, Zhang X, Fu B, Zhou Y, Yang M, Cao M, Chen Y, Tan Y, Shi Y, Wu L, Xuan C, Du Q, Hu R. | 09/3/2024 |
| The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction. | The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction.
Acquarone E, Argyrousi EK, Arancio O, Watterson DM, Roy SM., Free PMC Article | 04/26/2024 |
| Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer. | Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer.
Tu RH, Wu SZ, Huang ZN, Zhong Q, Ye YH, Zheng CH, Xie JW, Wang JB, Lin JX, Chen QY, Huang CM, Lin M, Lu J, Cao LL, Li P. | 12/6/2023 |
| Synergistic Interaction of 5-HT1B and 5-HT2B Receptors in Cytoplasmic Ca[2+] Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies. | Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.
Rybakova EY, Avdonin PP, Trufanov SK, Goncharov NV, Avdonin PV., Free PMC Article | 09/30/2023 |
| Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study. | Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study.
Penno JRCZ, Santos-Bezerra DP, Cavaleiro AM, da Silva Sousa AM, Zaccara TA, da Costa RA, Francisco RPV, Correa-Giannella ML., Free PMC Article | 07/25/2023 |
| Pulmonary 5-HT2B receptor expression in fibrotic interstitial lung diseases. | Pulmonary 5-HT(2B) receptor expression in fibrotic interstitial lung diseases.
Löfdahl A, Nybom A, Wigén J, Dellgren G, Brunnström H, Wenglén C, Westergren-Thorsson G. | 05/1/2023 |
| Targeting serotonin receptor 2B inhibits TGFbeta induced differentiation of human vascular smooth muscle cells. | Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells.
Wenglén C, Demirel I, Eremo AG, Grenegård M, Paramel GV. | 03/7/2023 |
| miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4. | miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4.
De Logu F, Maglie R, Titiz M, Poli G, Landini L, Marini M, Souza Monteiro de Araujo D, De Siena G, Montini M, Cabrini DA, Otuki MF, Pawloski PL, Antiga E, Tuccinardi T, Calixto JB, Geppetti P, Nassini R, André E. | 12/31/2022 |
| Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma. | Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma.
Benhassine M, Le-Bel G, Guérin SL., Free PMC Article | 03/12/2022 |
| The role of 5-HT2B-receptors in fluoxetine-mediated modulation of Th17- and Th1-cells in multiple sclerosis. | The role of 5-HT(2B)-receptors in fluoxetine-mediated modulation of Th17- and Th1-cells in multiple sclerosis.
Sviridova A, Rogovskii V, Kudrin V, Pashenkov M, Boyko A, Melnikov M. | 09/11/2021 |
| A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population. | A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population.
Lacoste J, Lamy S, Ramoz N, Ballon N, Jehel L, Maroteaux L, Thibaut F. | 05/8/2021 |
| Free energy calculations of the functional selectivity of 5-HT2B G protein-coupled receptor. | Free energy calculations of the functional selectivity of 5-HT2B G protein-coupled receptor.
Peters BL, Deng J, Ferguson AL., Free PMC Article | 01/23/2021 |
| This study uses over 25mus of unbiased atomistic molecular dynamics simulations to identify cholesterol interaction sites in the 5-HT1B and 5-HT2B receptors and evaluate their impact on receptor structure. | Influence of Cholesterol and Its Stereoisomers on Members of the Serotonin Receptor Family.
Oakes V, Domene C. | 03/28/2020 |
| We identified genome-wide significant risk loci contributing to CRA in AAs at the serotonin receptor 2B receptor gene (HTR2B), and the lead SNP, HTR2B*rs17440378, showed nominal association to aggression in the GTP cohort of cannabis-exposed subjects. | Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.
Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J., Free PMC Article | 09/21/2019 |
| In humans, mitral valve prolapse is associated with an upregulation in 5HTR2B expression and increased 5HT receptor signaling in the leaflets. | Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation.
Driesbaugh KH, Branchetti E, Grau JB, Keeney SJ, Glass K, Oyama MA, Rioux N, Ayoub S, Sacks MS, Quackenbush J, Levy RJ, Ferrari G., Free PMC Article | 06/29/2019 |
| findings support a role for the serotonin receptor 2B in the proliferation and migration of uveal melanoma cells, through activation of many signaling pathways such as WNT, Focal adhesion kinase and Janus kinase/STAT | Expression of the serotonin receptor 2B in uveal melanoma and effects of an antagonist on cell lines.
Weidmann C, Bérubé J, Piquet L, de la Fouchardière A, Landreville S. | 02/16/2019 |
| HTR2B transcription is regulated by NFI and RUNX1 in uveal melanoma cells. | Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma.
Benhassine M, Guérin SL., Free PMC Article | 02/2/2019 |
| The biological role of 5-HT2B which may act not only as a neurotransmitter receptor. | Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
Szabo A, Gogolak P, Koncz G, Foldvari Z, Pazmandi K, Miltner N, Poliska S, Bacsi A, Djurovic S, Rajnavolgyi E., Free PMC Article | 12/22/2018 |
| The 3.0-A resolution structure of a complex between the human 5-hydroxytryptamine 2B (5-HT2B) receptor and an antibody Fab fragment bound to the extracellular side of the receptor reveals the mechanism of selectivity in extracellular recognition of the receptor by monoclonal antibodies. | Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.
Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V., Free PMC Article | 05/19/2018 |
| These findings suggest that 5-HT promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones | Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes.
Hori A, Nishida T, Takashiba S, Kubota S, Takigawa M., Free PMC Article | 12/30/2017 |
| MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. | Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer.
Bao L, Zhang Y, Wang J, Wang H, Dong N, Su X, Xu M, Wang X. | 09/23/2017 |
| The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels. | The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males.
Tikkanen R, Saukkonen T, Fex M, Bennet H, Rautiainen MR, Paunio T, Koskinen M, Panarsky R, Bevilacqua L, Sjöberg RL, Tiihonen J, Virkkunen M. | 09/9/2017 |
| Study describes the crystal structure of Lysergic acid diethylamide (LSD) in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety. | Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL., Free PMC Article | 06/3/2017 |
| heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively. | Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT(2C) protomers.
Moutkine I, Quentin E, Guiard BP, Maroteaux L, Doly S., Free PMC Article | 04/29/2017 |
| The 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion. | Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men.
Tikkanen R, Saukkonen T, Fex M, Bennet H, Rautiainen MR, Paunio T, Koskinen M, Panarsky R, Bevilacqua L, Sjöberg RL, Tiihonen J, Virkkunen M. | 03/4/2017 |