In Drosophila, reduced insulin/IGF signaling extends lifespan by coordinating activation of Aop and Foxo. Aop and Foxo bind the same genomic loci, and individually, they affect similar transcriptional programs in vivo. In combination, Aop can both moderate or synergise with Foxo, dependent on promoter context. Also, Foxo and Aop oppose the gene-regulatory activity of Pnt. | Longevity is determined by ETS transcription factors in multiple tissues and diverse species. Dobson AJ, Boulton-McDonald R, Houchou L, Svermova T, Ren Z, Subrini J, Vazquez-Prada M, Hoti M, Rodriguez-Lopez M, Ibrahim R, Gregoriou A, Gkantiragas A, Bähler J, Ezcurra M, Alic N., Free PMC Article | 12/21/2019 |
a spectacular range of affinities lies latent within the SAM domain of Yan, and that these affinities must be tuned to preserve transcriptional repression and biological function during development. | Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Hope CM, Webber JL, Tokamov SA, Rebay I., Free PMC Article | 03/2/2019 |
a new layer of regulation whereby Yan and Pointed co-occupy regulatory elements to repress gene expression in a coordinated manner, with Pointed being unexpectedly required for the genome-wide occupancy of both Yan and the co-repressor Groucho. | Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Webber JL, Zhang J, Massey A, Sanchez-Luege N, Rebay I., Free PMC Article | 08/4/2018 |
Yan recruitment promoted by this high-affinity ETS supersite not only biases Yan-Pnt competition at the specific CRM but also organizes Yan-repressive complexes in three dimensions across the eve locus | Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Boisclair Lachance JF, Webber JL, Hong L, Dinner AR, Rebay I., Free PMC Article | 06/30/2018 |
DNA Occupancy of Polymerizing Transcription Factors | DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan. Hope CM, Rebay I, Reinitz J., Free PMC Article | 07/1/2017 |
We show that acal lies downstream of raw, a pioneer protein and interacts genetically with two genes involved in JNK signaling and dorsal closure: Connector of kinase to AP1 (Cka) and anterior open. | acal is a long non-coding RNA in JNK signaling in epithelial shape changes during drosophila dorsal closure. Ríos-Barrera LD, Gutiérrez-Pérez I, Domínguez M, Riesgo-Escovar JR., Free PMC Article | 05/16/2016 |
Study identifies the E-twenty six (ETS) transcriptional repressor, Anterior open (Aop), as central to lifespan extension caused by reduced insulin/IGF-1 or Ras attenuation. | The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity. Slack C, Alic N, Foley A, Cabecinha M, Hoddinott MP, Partridge L., Free PMC Article | 09/26/2015 |
instances of co-expressed Yan and Pnt-GFP in tissues with high RTK signaling cannot be explained by the current model, and thus they provide important contexts for future investigation of how context-specific differences in RTK signaling | A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling. Boisclair Lachance JF, Peláez N, Cassidy JJ, Webber JL, Rebay I, Carthew RW., Free PMC Article | 03/8/2014 |
Anterior open inhibits MAP kinase and Wingless signaling to couple tracheal cell fate with branch identity. | The ETS domain transcriptional repressor Anterior open inhibits MAP kinase and Wingless signaling to couple tracheal cell fate with branch identity. Caviglia S, Luschnig S. | 05/4/2013 |
a low level of Notch signaling functions to maintain the neuroepithelial cell identity by suppressing the expression of pointedP1 gene through the transcriptional repressor Anterior open. | Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia. Weng M, Haenfler JM, Lee CY., Free PMC Article | 04/13/2013 |
Bam and mir-7 antagonize the differentiation-promoting function of Yan to maintain the stem-like hematopoietic progenitor state during hematopoiesis. | Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis. Tokusumi T, Tokusumi Y, Hopkins DW, Shoue DA, Corona L, Schulz RA., Free PMC Article | 11/5/2011 |
full-length Yan self associates via its N-terminal sterile alpha motif (SAM) domain to form higher-order complexes in living cells | Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan. Zhang J, Graham TG, Vivekanand P, Cote L, Cetera M, Rebay I., Free PMC Article | 03/29/2010 |
Fbl6 regulates Tel/Yan protein stability and allows appropriate spatiotemporal control of gene expression by these repressors. | Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. Roukens MG, Alloul-Ramdhani M, Moghadasi S, Op den Brouw M, Baker DA., Free PMC Article | 01/21/2010 |
Yan functions to modulate the turnover of DE-Cadherin-dependent adhesive complexes to facilitate border cell migration | Function of the ETS transcription factor Yan in border cell migration. Schober M, Rebay I, Perrimon N. | 01/21/2010 |
results show that the dynamic expression of the yan gene is specified by distinct spatial and temporal cis-acting regulatory elements in embryos and larval tissues | Identifying functional cis-acting regulatory modules of the yan gene in Drosophila melanogaster. Ramos E, Price M, Rohrbaugh M, Lai ZC. | 01/21/2010 |
Yan regulates Lozenge during eye development | Yan regulates Lozenge during Drosophila eye development. Behan KJ, Nichols CD, Cheung TL, Farlow A, Hogan BM, Batterham P, Pollock JA. | 01/21/2010 |
A reversible loop of Yan phosphorylation implements a zero-order ultrasensitivity-like threshold mechanism, with the capacity to form sharp thresholds that are independent of the level of Yan. | Threshold responses to morphogen gradients by zero-order ultrasensitivity. Melen GJ, Levy S, Barkai N, Shilo BZ., Free PMC Article | 01/21/2010 |
prior to Ras activation, the Mae/Yan interaction blocks premature nuclear export of Yan monomers | Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Song H, Nie M, Qiao F, Bowie JU, Courey AJ., Free PMC Article | 01/21/2010 |
Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases. | Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Qiao F, Song H, Kim CA, Sawaya MR, Hunter JB, Gingery M, Rebay I, Courey AJ, Bowie JU. | 01/21/2010 |