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    XIAP X-linked inhibitor of apoptosis [ Homo sapiens (human) ]

    Gene ID: 331, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Interleukin-1-mediated hyperinflammation in XIAP deficiency is associated with defective autophagy.

    Interleukin-1-mediated hyperinflammation in XIAP deficiency is associated with defective autophagy.
    Dissanayake D, Firouzabady A, Massumi M, de Paz Linares GA, Marshall C, Freeman SA, Laxer RM, Yeung RSM.

    11/5/2024
    Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer.

    Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer.
    Qi Q, Zhu M, Li P, Mi Q, Xie Y, Li J, Wang C.

    04/18/2024
    Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease.

    Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease.
    Lee J, Sim KM, Kang M, Oh HJ, Choi HJ, Kim YE, Pack CG, Kim K, Kim KM, Oh SH, Kim I, Chang I., Free PMC Article

    02/5/2024
    Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis.

    Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis.
    Patterson LL, Byerly CD, Solomon R, Pittner N, Bui DC, Patel J, McBride JW., Free PMC Article

    09/18/2023
    Nicotine promotes renal interstitial fibrosis via upregulation of XIAP in an alpha7-nAChR-dependent manner.

    Nicotine promotes renal interstitial fibrosis via upregulation of XIAP in an alpha7-nAChR-dependent manner.
    Guo L, Zhang Y, Lu J, Li X, Zhang C, Song W, Dong Y, Zhou X, Li R.

    09/8/2023
    Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1beta release in X-linked inhibitor of apoptosis (XIAP) deficiency.

    Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency.
    Hughes SA, Lin M, Weir A, Huang B, Xiong L, Chua NK, Pang J, Santavanond JP, Tixeira R, Doerflinger M, Deng Y, Yu CH, Silke N, Conos SA, Frank D, Simpson DS, Murphy JM, Lawlor KE, Pearson JS, Silke J, Pellegrini M, Herold MJ, Poon IKH, Masters SL, Li M, Tang Q, Zhang Y, Rashidi M, Geng L, Vince JE., Free PMC Article

    03/3/2023
    XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.

    XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.
    Yang B, Lou C, Chen S, Zhang Z, Xu Q.

    02/11/2023
    Caspase-3, Caspase-8 and XIAP Gene Expression in the Placenta: Exploring the Causes of Spontaneous Preterm Labour.

    Caspase-3, Caspase-8 and XIAP Gene Expression in the Placenta: Exploring the Causes of Spontaneous Preterm Labour.
    Belousova V, Svitich O, Timokhina E, Ignatko I, Bogomazova I, Pesegova S, Silaeva T, Kuzmina T, Skorobogatova O., Free PMC Article

    02/4/2023
    X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients.

    X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients.
    Parvathareddy SK, Siraj AK, Bu R, Iqbal K, Al-Rasheed M, Al-Haqawi W, Annaiyappanaidu P, Siraj N, Ahmed SO, Al-Sobhi SS, Al-Dayel F, Al-Kuraya KS., Free PMC Article

    01/11/2023
    miR-515-5p suppresses trophoblast cell invasion and proliferation through XIAP regulation in preeclampsia.

    miR-515-5p suppresses trophoblast cell invasion and proliferation through XIAP regulation in preeclampsia.
    Nunode M, Hayashi M, Nagayasu Y, Sawada M, Nakamura M, Sano T, Fujita D, Ohmichi M.

    11/26/2022
    Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1.

    Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1.
    Engelmann C, Schuhmachers P, Zdimerova H, Virdi S, Hauri-Hohl M, Pachlopnik Schmid J, Grundhoff A, Marsh RA, Wong WW, Münz C., Free PMC Article

    10/29/2022
    BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors.

    BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors.
    Cremona M, Vandenberg CJ, Farrelly AM, Madden SF, Morgan C, Kalachand R, McAlpine JN, Toomey S, Huntsman DG, Grogan L, Breathnach O, Morris P, Carey MS, Scott CL, Hennessy BT., Free PMC Article

    10/22/2022
    Identification of Circular RNA circ_0017068 as a Regulator of Proliferation and Apoptosis in Trophoblast Cells by miR-330-5p/XIAP Axis.

    Identification of Circular RNA circ_0017068 as a Regulator of Proliferation and Apoptosis in Trophoblast Cells by miR-330-5p/XIAP Axis.
    Wang W, Shi J, Zheng L.

    08/13/2022
    X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc).

    X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc).
    Bergmann C, Hallenberger L, Chenguiti Fakhouri S, Merlevede B, Brandt A, Dees C, Zhu H, Zehender A, Zhou X, Schwab A, Chen CW, Györfi AH, Matei AE, Chakraborty D, Trinh-Minh T, Rauber S, Coras R, Bozec A, Kreuter A, Ziemer M, Schett G, Distler JHW.

    07/2/2022
    XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.

    XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
    Daoud M, Broxtermann PN, Schorn F, Werthenbach JP, Seeger JM, Schiffmann LM, Brinkmann K, Vucic D, Tüting T, Mauch C, Kulms D, Zigrino P, Kashkar H., Free PMC Article

    06/25/2022
    SIAH1 promotes senescence and apoptosis of nucleus pulposus cells to exacerbate disc degeneration through ubiquitinating XIAP.

    SIAH1 promotes senescence and apoptosis of nucleus pulposus cells to exacerbate disc degeneration through ubiquitinating XIAP.
    Fang S, Zeng F, Chen R, Li M.

    06/11/2022
    Identification of Germline Non-coding Deletions in XIAP Gene Causing XIAP Deficiency Reveals a Key Promoter Sequence.

    Identification of Germline Non-coding Deletions in XIAP Gene Causing XIAP Deficiency Reveals a Key Promoter Sequence.
    Sbihi Z, Tanita K, Bachelet C, Bole C, Jabot-Hanin F, Tores F, Le Loch M, Khodr R, Hoshino A, Lenoir C, Oleastro M, Villa M, Spossito L, Prieto E, Danielian S, Brunet E, Picard C, Taga T, Abdrabou SSMA, Isoda T, Yamada M, Palma A, Kanegane H, Latour S.

    04/23/2022
    Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases.

    Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases.
    Devi Daimary U, Girisa S, Parama D, Verma E, Kumar A, Kunnumakkara AB.

    04/2/2022
    Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.

    Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
    Strigli A, Gopalakrishnan S, Zeissig Y, Basic M, Wang J, Schwerd T, Doms S, Peuker K, Hartwig J, Harder J, Hönscheid P, Arnold P, Kurth T, Rost F, Petersen BS, Forster M, Franke A, Kelsen JR, Rohlfs M, Klein C, Muise AM, Warner N, Nambu R, Mayerle J, Török HP, Linkermann A, Muders MH, Baretton GB, Hampe J, Aust DE, Baines JF, Bleich A, Zeissig S.

    03/12/2022
    XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.

    XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
    Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M.

    03/12/2022
    Circ_0000527 Promotes Retinoblastoma Progression through Modulating miR-98-5p/XIAP Pathway.

    Circ_0000527 Promotes Retinoblastoma Progression through Modulating miR-98-5p/XIAP Pathway.
    Yu B, Zhao J, Dong Y.

    03/5/2022
    Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis.

    Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis.
    Lu X, Gao H, Zhu B, Lin G., Free PMC Article

    01/22/2022
    Interpretation of XIAP Variants of Uncertain Significance in Paediatric Patients with Refractory Crohn's Disease.

    Interpretation of XIAP Variants of Uncertain Significance in Paediatric Patients with Refractory Crohn's Disease.
    Chang I, Park S, Lee HJ, Kim I, Park S, Ahn MK, Lee J, Kang M, Baek IJ, Sung YH, Pack CG, Kang HJ, Lee K, Im HJ, Seo EJ, Kim KM, Yang SK, Song K, Oh SH.

    12/18/2021
    MiR-134-5p targeting XIAP modulates oxidative stress and apoptosis in cardiomyocytes under hypoxia/reperfusion-induced injury.

    MiR-134-5p targeting XIAP modulates oxidative stress and apoptosis in cardiomyocytes under hypoxia/reperfusion-induced injury.
    Lu M, Qin X, Yao J, Yang Y, Zhao M, Sun L.

    12/4/2021
    Biophysical characterization of the interaction between the full-length XIAP and Smac/DIABLO.

    Biophysical characterization of the interaction between the full-length XIAP and Smac/DIABLO.
    Polykretis P, Luchinat E.

    11/22/2021
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