| Data show that normal Ci-155 activation by Hh requires Cos2 binding to Fu, supporting the hypothesis that Cos2 mediates the apposition of Fu molecules suitable for cross-phosphorylation and consequent full activation of Fu kinase. | Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila.
Zadorozny EV, Little JC, Kalderon D., Free PMC Article | 04/25/2015 |
| Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. | Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.
Zhang Y, Mao F, Lu Y, Wu W, Zhang L, Zhao Y., Free PMC Article | 01/21/2012 |
| Hh-induced Smo conformational change facilitates the assembly of active Smo-Cos2-Fu signaling complexes that promote Fu kinase domain dimerization, phosphorylation and activation; Fu regulates both the activator and repressor forms of Ci | The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.
Shi Q, Li S, Jia J, Jiang J., Free PMC Article | 11/26/2011 |
| Study shows that Fused (Fu), a serine/threonine kinase that regulates Hedgehog, functions in concert with the E3 ligase Smurf to regulate ubiquitination and proteolysis of the BMP receptor Thickveins in germline stem cells daughter cystoblasts. | The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response.
Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D. | 01/22/2011 |
| Data suggest that, after activation of Smoothened, the Fused kinase induces a conformational change in Costal2 that allows the disassembly of the Smo-Fu-Cos2-Cubitus interruptus complex and consequent activation of Hedgehog target genes. | Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.
Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, Cervantes A, Thérond PP. | 01/21/2010 |
| Findings reveal a novel positive-feedback loop in Hedgehog transduction and support a model in which Fused and SMO enhance each other's activities & sustain high levels of signaling and render the pathway robust to Patched level fluctuations. | Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.
Claret S, Sanial M, Plessis A. | 01/21/2010 |
| positive role for Fused in the transduction of somatic Hedgehog signaling instructing ovariole morphogenesis | Hedgehog signaling controls Soma-Germen interactions during Drosophila ovarian morphogenesis.
Besse F, Busson D, Pret AM. | 01/21/2010 |
| Data show that the Costal2-Fused-Cubitus interruptus (Cos2-Fu-Ci) protein complex is associated with Smoothened (Smo) in membrane fractions, and that Cos2 binding on Smo is necessary for the Hedgehog-dependent dissociation of Ci from this complex. | Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog.
Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Thérond PP. | 01/21/2010 |
| Hedgehog signaling requires an intramolecular association between two domains of the protein kinase Fused | An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.
Ascano M Jr, Robbins DJ., Free PMC Article | 01/21/2010 |
| we provide evidence that fused regulates these cystocyte divisions cell autonomously, while the tumorous phenotype probably reflects both a somatic and germline requirement for fused for cyst and follicle development. | fused regulates germline cyst mitosis and differentiation during Drosophila oogenesis.
Narbonne-Reveau K, Besse F, Lamour-Isnard C, Busson D, Pret AM. | 01/21/2010 |
| model in which Hedgehog signals at least twice in germarial somatic cells: through a fused-independent pathway to control somatic stem cell proliferation; and through a classical fused-dependent pathway to regulate prefollicular cell differentiation | Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation.
Besse F, Busson D, Pret AM. | 01/21/2010 |
| This protein is a component of the Ci signaling complex that regulates Ci nuclear import and cleavage. | Genetic dissection of the Drosophila Cubitus interruptus signaling complex.
Lefers MA, Wang QT, Holmgren RA. | 09/23/2001 |