| Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma. | Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma.
Liu X, Zhang J, Zhang D, Pan Y, Zeng R, Xu C, Shi S, Xu J, Qi Q, Dong X, Wang J, Liu T, Dong L., Free PMC Article | 08/2/2024 |
| TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation. | TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation.
Schmitt P, Duval A, Camus M, Lefrançais E, Roga S, Dedieu C, Ortega N, Bellard E, Mirey E, Mouton-Barbosa E, Burlet-Schiltz O, Gonzalez-de-Peredo A, Cayrol C, Girard JP., Free PMC Article | 04/24/2024 |
| Roles of tumor necrosis factor-like ligand 1A in gammadeltaT-cell activation and psoriasis pathogenesis. | Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis.
Wang S, Kozai M, Hiraishi M, Rubel MZU, Ichii O, Inaba M, Matsuo K, Takada K., Free PMC Article | 02/20/2024 |
| TNFSF15 facilitates the differentiation of CD11b[+] myeloid cells into vascular pericytes in tumors. | TNFSF15 facilitates the differentiation of CD11b(+) myeloid cells into vascular pericytes in tumors.
Gu X, Zhu Y, Zhao C, Cao Y, Wang J, Zhang Q, Li L., Free PMC Article | 12/5/2023 |
| TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes. | TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes.
Wang G, Shen J, Zhai L, Lin Y, Guan Q, Shen H., Free PMC Article | 11/28/2023 |
| Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption. | Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
Zhang D, Zhang J, Zhang J, Ji X, Qi Q, Xu J, Pan Y, Liu X, Sun F, Zeng R, Dong L., Free PMC Article | 07/13/2023 |
| TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth. | TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth.
Zhao CC, Han QJ, Ying HY, Gu XX, Yang N, Li LY, Zhang QZ., Free PMC Article | 04/16/2022 |
| A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury. | A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury.
Yang GL, Wang S, Zhang S, Liu Y, Liu X, Wang D, Wei H, Xiong J, Zhang ZS, Wang Z, Li LY, Zhang J., Free PMC Article | 01/22/2022 |
| Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis. | Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
Wenxiu J, Mingyue Y, Fei H, Yuxin L, Mengyao W, Chenyang L, Jia S, Hong Z, Shih DQ, Targan SR, Xiaolan Z., Free PMC Article | 01/8/2022 |
| Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy. | Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy.
Li J, Xie R, Jiang F, Li Y, Zhu Y, Liu Z, Liao M, Liu Y, Meng X, Chen S, Yu J, Du M, Wang X, Chen Y, Yan H. | 11/13/2021 |
| Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Ralpha in Muco-Secretory Fibrotic Disorders. | Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders.
Steele H, Sachen K, McKnight AJ, Soloff R, Herro R., Free PMC Article | 10/30/2021 |
| TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice. | TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice.
Tougaard P, Martinsen LO, Lützhøft DO, Jensen HE, Flethøj M, Vandenabeele P, Pedersen AE, Skov S, Hansen AK, Hansen CHF. | 09/11/2021 |
| Effects of tumor necrosis factor-like ligand 1A (TL1A) on imiquimod-induced psoriasiform skin inflammation in mice. | Effects of tumor necrosis factor-like ligand 1A (TL1A) on imiquimod-induced psoriasiform skin inflammation in mice.
Li L, Fu L, Zhou P, Lu Y, Zhang L, Wang W, Nie J, Zhang D, Liu Y, Wu B, Chen T. | 05/15/2021 |
| Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo. | Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Luu J, Blackwood AY, Castanon SL, Stamps DT, Thomas LS, Gonsky R, Shih DQ, Michelsen KS, Targan SR., Free PMC Article | 05/15/2021 |
| TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling. | TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling.
Herro R, Miki H, Sethi GS, Mills D, Mehta AK, Nguyen XX, Feghali-Bostwick C, Miller M, Broide DH, Soloff R, Croft M., Free PMC Article | 04/3/2021 |
| TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells. | TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.
Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, Wang X, Chen Y, Li L, Zhang Z, Duan Y, Han J, Yang X., Free PMC Article | 03/13/2021 |
| Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease. | Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
Mavers M, Simonetta F, Nishikii H, Ribado JV, Maas-Bauer K, Alvarez M, Hirai T, Turkoz M, Baker J, Negrin RS., Free PMC Article | 10/3/2020 |
| In contrast to pre-menopausal females, post-menopausal serum levels of TL1A are not significantly elevated and that DR3 expression is not induced on CD14+ monocytes. Murine ovariectomy (OVX) model of estrogen-deficiency revealed that early post-OVX expression of DR3 on CD4+ T cells is significantly elevated suggesting that DR3 and TL1A could play a potentially indirect role in early post-menopausal bone loss. | Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.
Collins FL, Stone MD, Turton J, McCabe LR, Wang ECY, Williams AS., Free PMC Article | 01/4/2020 |
| TL1A could impair intestinal epithelial barrier in the mouse model of colitis and might regulate tight junction expression via MLCK/p-MLC pathway and LPS-mediated MyD88/TRAF6 pathway. | Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis.
Yang M, Jia W, Wang D, Han F, Niu W, Zhang H, Shih DQ, Zhang X. | 12/28/2019 |
| Authors presented a possible mechanism of TL1A in UC development that TL1A may promote the differentiation of Th9 cells and enhanced IL-9 secretion by up-regulating the expression of TGF-beta, IL-4 and PU.1. | TL1A modulates the severity of colitis by promoting Th9 differentiation and IL-9 secretion.
Wang D, Li H, Duan YY, Han F, Luo YX, Wu MY, Yang MY, Zhan RR, Song J, Zhang H, Zhang XL. | 09/21/2019 |
| Tl1a-mediated intestinal fibrosis and fibroblast activation are dependent on specific microbial populations. | Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome.
Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ., Free PMC Article | 07/27/2019 |
| These results indicated that constitutive TL1A expression in myeloid cells exacerbated liver fibrosis, probably through macrophage recruitment and secretion of proinflammatory and profibrotic cytokines. | Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.
Guo J, Luo Y, Yin F, Huo X, Niu G, Song M, Chen S, Zhang X., Free PMC Article | 06/29/2019 |
| Results indicate a role for group 3 innate lymphoid cell (ILC3) in activating intestinal T cells and a central role for TNF-like ligand 1A (TL1A) in promoting ILC3 barrier immunity during colitis. | Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.
Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS., Free PMC Article | 06/1/2019 |
| These data suggest differential roles for membrane and soluble TL1A on adaptive and innate immune cells | Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Ferdinand JR, Richard AC, Meylan F, Al-Shamkhani A, Siegel RM., Free PMC Article | 03/2/2019 |
| TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis | TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice.
Li H, Song J, Niu G, Zhang H, Guo J, Shih DQ, Targan SR, Zhang X. | 09/1/2018 |