| TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes. | TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.
Zhang T, Linghu KG, Tan J, Wang M, Chen D, Shen Y, Wu J, Shi M, Zhou Y, Tang L, Liu L, Qin ZH, Guo B., | 08/20/2024 |
| Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis. | Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
Wang D, Li Y, Yang H, Shen X, Shi X, Li C, Zhang Y, Liu X, Jiang B, Zhu X, Zhang H, Li X, Bai H, Yang Q, Gao W, Bai F, Ji Y, Chen Q, Ben J., Free PMC Article | 05/29/2024 |
| Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure. | Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure.
He X, Zeng H, Cantrell AC, Williams QA, Chen JX., Free PMC Article | 08/20/2022 |
| TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner. | TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner.
Liu M, Zhou X, Li Y, Ma S, Pan L, Zhang X, Zheng W, Wu Z, Wang K, Ahsan A, Wu J, Jiang L, Lu Y, Hu W, Qin Z, Chen Z, Zhang X., Free PMC Article | 06/18/2022 |
| The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury. | The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
Du Y, Chu CM, Zhuo D, Ning JZ. | 05/21/2022 |
| TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling. | TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling.
Tang Y, Zong H, Kwon H, Qiu Y, Pessin JB, Wu L, Buddo KA, Boykov I, Schmidt CA, Lin CT, Neufer PD, Schwartz GJ, Kurland IJ, Pessin JE., Free PMC Article | 05/7/2022 |
| TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury. | TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
He X, Cantrell AC, Williams QA, Chen JX, Zeng H., Free PMC Article | 04/30/2022 |
| TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function. | TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function.
Huang SS, Sheng YC, Jiang YY, Liu N, Lin MM, Wu JC, Liang ZQ, Qin ZH, Wang Y. | 03/19/2022 |
| Regulatory role of TIGAR on endothelial metabolism and angiogenesis. | Regulatory role of TIGAR on endothelial metabolism and angiogenesis.
He X, Zeng H, Cantrell AC, Chen JX., Free PMC Article | 12/18/2021 |
| Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death. | Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Domostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia-Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J., Free PMC Article | 12/4/2021 |
| Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism. | Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
Li L, Zeng H, He X, Chen JX., Free PMC Article | 10/16/2021 |
| TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages. | TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages.
Zhao ZW, Zhang M, Zou J, Wan XJ, Zhou L, Wu Y, Liu SM, Liao LX, Li H, Qin YS, Yu XH, Tang CK. | 07/17/2021 |
| TIGAR/AP-1 axis accelerates the division of Lgr5(-) reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation. | TIGAR/AP-1 axis accelerates the division of Lgr5(-) reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation.
Chen F, Zhang Y, Hu S, Shi X, Wang Z, Deng Z, Lin L, Zhang J, Pan Y, Bai Y, Liu F, Zhang H, Shao C., Free PMC Article | 03/27/2021 |
| TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension. | TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension.
Yamanaka R, Hoshino A, Fukai K, Urata R, Minami Y, Honda S, Fushimura Y, Hato D, Iwai-Kanai E, Matoba S. | 12/12/2020 |
| The study is the first to indicate that Wnt signaling activates TIGAR and protects SGNs against cisplatin-induced damage through the inhibition of oxidative stress and apoptosis in SGNs, and this might offer novel therapeutic targets for the prevention of SGN injury. | Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea.
Liu W, Xu X, Fan Z, Sun G, Han Y, Zhang D, Xu L, Wang M, Wang X, Zhang S, Tang M, Li J, Chai R, Wang H. | 07/18/2020 |
| The results suggest that p53-TIGAR metabolic axis-mediated glycolytic suppression may play a compensatory role in attenuating DNA damage and proliferative exhaustion in Fanconi Anemia hematopoietic stem cells. | p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells.
Li X, Wu L, Zopp M, Kopelov S, Du W., Free PMC Article | 06/27/2020 |
| this study shows that TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury | TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.
Zhang DM, Zhang T, Wang MM, Wang XX, Qin YY, Wu J, Han R, Sheng R, Wang Y, Chen Z, Han F, Ding Y, Li M, Qin ZH. | 06/13/2020 |
| TIGAR regulates mitochondrial function through SIRT1-PGC1alpha and translocation of TIGAR into mitochondria, which contribute to exercise endurance of mice. | TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.
Geng J, Wei M, Yuan X, Liu Z, Wang X, Zhang D, Luo L, Wu J, Guo W, Qin ZH. | 05/23/2020 |
| These data indicate a role for TIGAR in modulating redox homeostasis during oocyte maturation. | Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice.
Wang H, Cheng Q, Li X, Hu F, Han L, Zhang H, Li L, Ge J, Ying X, Guo X, Wang Q., Free PMC Article | 05/4/2019 |
| Study demonstrated that TIGAR played a positive role in survival of astrocytes and a negative role in inflammatory response after stroke attack. TIGAR exerted these functions through increasing flux of pentose phosphate pathway and inhibiting NF-kappaB activation. | TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes.
Chen J, Zhang DM, Feng X, Wang J, Qin YY, Zhang T, Huang Q, Sheng R, Chen Z, Li M, Qin ZH. | 11/24/2018 |
| TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis. | TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis.
Zhou JH, Zhang TT, Song DD, Xia YF, Qin ZH, Sheng R., Free PMC Article | 04/7/2018 |
| Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury. | Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury.
Cao L, Chen J, Li M, Qin YY, Sun M, Sheng R, Han F, Wang G, Qin ZH., Free PMC Article | 06/28/2016 |
| Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 or TAp73. | p53- and p73-independent activation of TIGAR expression in vivo.
Lee P, Hock AK, Vousden KH, Cheung EC., Free PMC Article | 04/16/2016 |
| TIGAR protein expression in brain is increased following ischemia reperfusion injury. | Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism.
Sun M, Li M, Huang Q, Han F, Gu JH, Xie J, Han R, Qin ZH, Zhou Z. | 10/3/2015 |
| Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 nuclear translocation. | Radiosensitization of glioma cells by TP53-induced glycolysis and apoptosis regulator knockdown is dependent on thioredoxin-1 nuclear translocation.
Zhang H, Gu C, Yu J, Wang Z, Yuan X, Yang L, Wang J, Jia Y, Liu J, Liu F. | 11/22/2014 |