| A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction. | A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction.
Cheon Y, Yoon S, Lee JH, Kim K, Kim HJ, Hong SW, Yun YR, Shim J, Kim SH, Lu B, Lee M, Lee S., Free PMC Article | 08/25/2023 |
| Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila. | Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila.
Katti P, Rai M, Srivastava S, D'Silva P, Nongthomba U. | 06/12/2021 |
| Depletion of Mitofusin (dMfn) or Opa1 led to dysfunctional mitochondria, activation of Target of rapamycin (TOR) and a marked accumulation of lipid droplets. Enhancement of lipid utilization by the mitochondria attenuated TOR activation and rescued the loss of GSCs that was caused by inhibition of mitochondrial fusion. | Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis.
Sênos Demarco R, Uyemura BS, D'Alterio C, Jones DL. | 07/13/2019 |
| both dominant negative and dominant active forms of mitofusin can cause Charcot-Marie-Tooth disease type 2A-associated defects. | Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy.
El Fissi N, Rojo M, Aouane A, Karatas E, Poliacikova G, David C, Royet J, Rival T., Free PMC Article | 05/18/2019 |
| binds cyclin A mRNA and shortens its poly-A tail to reduce Cyclin A protein level during oocyte maturation | LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes.
Zhu L, Kandasamy SK, Liao SE, Fukunaga R., Free PMC Article | 01/26/2019 |
| Enhancing the profusion gene mitofusin/marf is beneficial in an in vivo model of TDP-43 proteinopathies, serving as a potential therapeutic target. | Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies.
Khalil B, Cabirol-Pol MJ, Miguel L, Whitworth AJ, Lecourtois M, Liévens JC. | 11/18/2017 |
| activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria. | Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease.
Celardo I, Costa AC, Lehmann S, Jones C, Wood N, Mencacci NE, Mallucci GR, Loh SH, Martins LM., Free PMC Article | 09/23/2017 |
| Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance. | Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.
Wang ZH, Clark C, Geisbrecht ER., Free PMC Article | 07/29/2017 |
| lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK pathway. In addition, depletion of other mitochondrial fusion components, Opa1 or Marf, inactivates the Hippo pathway as well. | Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development.
Deng Q, Guo T, Zhou X, Xi Y, Yang X, Ge W., Free PMC Article | 05/27/2017 |
| Marf is required for mitochondrial fusion and transport in long axons. | Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production.
Sandoval H, Yao CK, Chen K, Jaiswal M, Donti T, Lin YQ, Bayat V, Xiong B, Zhang K, David G, Charng WL, Yamamoto S, Duraine L, Graham BH, Bellen HJ., Free PMC Article | 06/27/2015 |
| Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects. | Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion.
Debattisti V, Pendin D, Ziviani E, Daga A, Scorrano L., Free PMC Article | 04/12/2014 |
| Parkin deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin. | Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.
Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW 2nd., Free PMC Article | 03/29/2014 |
| mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology | Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila.
Eschenbacher WH, Song M, Chen Y, Bhandari P, Zhao P, Jowdy CC, Engelhard JT, Dorn GW 2nd., Free PMC Article | 02/16/2013 |
| Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf. | Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.
Thomenius M, Freel CD, Horn S, Krieser R, Abdelwahid E, Cannon R, Balasundaram S, White K, Kornbluth S., Free PMC Article | 04/21/2012 |
| MARF and Opa1 control mitochondrial and cardiac function in Drosophila. | MARF and Opa1 control mitochondrial and cardiac function in Drosophila.
Dorn GW 2nd, Clark CF, Eschenbacher WH, Kang MY, Engelhard JT, Warner SJ, Matkovich SJ, Jowdy CC., Free PMC Article | 02/26/2011 |
| The PINK1/Parkin pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies. | Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.
Ziviani E, Tao RN, Whitworth AJ., Free PMC Article | 05/3/2010 |
| Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line. | Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn.
Hwa JJ, Hiller MA, Fuller MT, Santel A. | 01/21/2010 |