| Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway. | Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
Han M, Zhang D, Ji J, Zhang J, Qin M., Free PMC Article | 01/29/2024 |
| Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway. | Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway.
Qin M, Li Q, Wang Y, Li T, Gu Z, Huang P, Ren L. | 06/12/2021 |
| Here, we demonstrate that 1) stimulation of cAMP production deactivates ischemia-reperfusion-induced hyperpermeability in muscle and endothelial cells; 2) VEGF mRNA expression is not enhanced by brief ischemia, suggesting that VEGF mechanisms do not activate immediate postischemic hyperpermeability; and 3) deactivation mechanisms operate via cAMP-exchange protein activated by cAMP 1-Rap1 to restore integrity of the endot | Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms.
Korayem AH, Mujica PE, Aramoto H, Durán RG, Nepali PR, Kim DD, Harris AL, Sánchez FA, Durán WN., Free PMC Article | 08/19/2017 |
| results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity | Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.
DiStefano PV, Smrcka AV, Glading AJ., Free PMC Article | 08/5/2017 |
| Rap1GAP negatively regulated GNDF-induced ERK activation and neurite outgrowth. | Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth.
Jiao L, Zhang Y, Hu C, Wang YG, Huang A, He C., Free PMC Article | 09/25/2012 |
| Data suggest that cAMP-dependent PACAP-induced GFAP expression during astrocytogenesis involves the coordinated activation of both Ras and Rap1, but activation of either one of them in isolation is not sufficient to trigger this response. | Pituitary adenylate cyclase-activating polypeptide stimulates glial fibrillary acidic protein gene expression in cortical precursor cells by activating Ras and Rap1.
Lastres-Becker I, Fernández-Pérez A, Cebolla B, Vallejo M. | 09/25/2012 |
| Disruption of the DEP-dependent subcellular targeting of Epac abolished cAMP-Epac-mediated Rap1 activation and thyroid-stimulating hormone-mediated cell proliferation | Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.
Hochbaum D, Hong K, Barila G, Ribeiro-Neto F, Altschuler DL. | 09/25/2012 |
| a model in which activation of G(z) results in recruitment of Rap1GAP to the membrane where it can effectively down-regulate Rap1 signaling (Rap1)(Rap1GAP) | Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
Meng J, Casey PJ. | 09/25/2012 |
| Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons | Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
Wang Y, Su B, Xia Z. | 09/25/2012 |
| Dynein- and microtubule-based transport is necessary for TrkA signaling to Rap1 and MAPK1/2 | A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.
Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC. | 09/25/2012 |
| Data implicate Rap1GAP as a putative tumor/invasion suppressor in the thyroid, and show that downregulation of Rap1GAP contributes to Ras transformation. | Downregulation of Rap1GAP contributes to Ras transformation.
Tsygankova OM, Prendergast GV, Puttaswamy K, Wang Y, Feldman MD, Wang H, Brose MS, Meinkoth JL., Free PMC Article | 09/25/2012 |
| Rac1 activation by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating rat cells | Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells.
Vallés AM, Beuvin M, Boyer B. | 09/25/2012 |
| Rap1GAP protein levels are tightly regulated and it may have a role as a tumor suppressor | Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability.
Tsygankova OM, Feshchenko E, Klein PS, Meinkoth JL. | 09/25/2012 |
| The transport of the signaling complex containing the p75 receptor and Rap1 may play a role in the effect of MAG (myelin-associated glycoprotein). | Rap1 is involved in the signal transduction of myelin-associated glycoprotein.
Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T. | 09/25/2012 |
| Rap1 bimodally regulates spine morphology: activated Rap1 recruits PDZ domain-containing protein AF-6 to plasma membrane and induces spine neck elongation, while inactive Rap1 dissociates AF-6 from membrane and induces spine enlargement. | Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6.
Xie Z, Huganir RL, Penzes P. | 09/25/2012 |
| These observations identify Rap1 as a key mediator of calcium regulation of CREB-dependent transcription and dendritic development. | Regulation of cortical dendrite development by Rap1 signaling.
Chen Y, Wang PY, Ghosh A. | 09/25/2012 |
| The data reveal a novel type of cross-talk between P2Y12 and IGF-I receptors that proceeds through Gbetagamma-, Ca2+-and PLD2-dependent activation of the Pyk2/Src pathway resulting in GTP-loading of Rap1 required for an increased PKB phosphorylation. | P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1.
Van Kolen K, Gilany K, Moens L, Esmans EL, Slegers H. | 09/25/2012 |
| Data suggest that the action of 8-pCPT-2'-O-Me-cAMP-AM is most likely mediated through Epac, and Epac-dependent activation of Rap1. | Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG., Free PMC Article | 01/21/2010 |
| adenylyl cyclase mediates nerve growth factor-induced activation of Rap1 | Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
Stessin AM, Zippin JH, Kamenetsky M, Hess KC, Buck J, Levin LR., Free PMC Article | 01/21/2010 |