| Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology. | Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology.
Liacini A, 't Hart DC, Peters L, Persidsky Y, Geier S. | 01/28/2023 |
| Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing. | Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing.
Cargou M, Andreani M, Troiano M, Ralazamahaleo M, Visentin J. | 09/4/2021 |
| Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing. | Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing.
Cargou M, Andreani M, Troiano M, Ralazamahaleo M, Visentin J. | 08/7/2021 |
| In contrast to HLA-DRB4*01:01P, the inheritance of HLA-DRB3*01:01 is strongly associated with the propensity for mounting a humoral immune response against fetal HPA-1a antigen. | HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia.
Wienzek-Lischka S, König IR, Papenkort EM, Hackstein H, Santoso S, Sachs UJ, Bein G. | 06/24/2017 |
| our findings provide clear evidence that the HLA-DRB1*15:01 and HLA-DRB3*02:02 alleles independently and strongly associate with phospholipase A2 receptor related idiopathic membranous nephropathy in the Chinese population | HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy.
Le WB, Shi JS, Zhang T, Liu L, Qin HZ, Liang S, Zhang YW, Zheng CX, Jiang S, Qin WS, Zhang HT, Liu ZH., Free PMC Article | 06/3/2017 |
| The first time that the haplotypes A33-DR3 and A33-DR9 were found with an enhanced predisposition to type 1 diabetes in Han Chinese. | HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.
Zhang J, Zhao L, Wang B, Gao J, Wang L, Li L, Cui B, Hu M, Hong J, Gu W, Wang W, Ning G., Free PMC Article | 02/18/2017 |
| HLA-DRB3 affects type 1 diabetes risk and islet autoantibodies. | Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.
Zhao LP, Alshiekh S, Zhao M, Carlsson A, Larsson HE, Forsander G, Ivarsson SA, Ludvigsson J, Kockum I, Marcus C, Persson M, Samuelsson U, Örtqvist E, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å, Better Diabetes Diagnosis (BDD) Study Group., Free PMC Article | 07/16/2016 |
| this mouse model unravels a critical role for HLA-DR3 in generating an autoimmune response to SmD and lupus nephritis in the NZM2328 background. | A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus.
Chowdhary VR, Dai C, Tilahun AY, Hanson JA, Smart MK, Grande JP, Rajagopalan G, Fu SM, David CS., Free PMC Article | 03/26/2016 |
| Haplotyping was done on 91 Southern Europe celiac patients. HLA-DR3-DQ2 without HLA-DR7-DQ2 was present in 62.6%, HLA-DR7-DQ2 without HLA-DR3-DQ2 was present in 16.5% and HLA-DR4-DQ8 without HLA-DQ2 was present in 3.3%. | Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences.
Delgado JF, Amengual MJ, Veraguas A, Rodríguez E, de Los Santos MM, Guallarte MP. | 01/10/2015 |
| Children with the HLA haplotype DR3-DQ2, especially homozygotes, were found to be at high risk for celiac disease autoimmunity and celiac disease early in childhood. | Risk of pediatric celiac disease according to HLA haplotype and country.
Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D, TEDDY Study Group., Free PMC Article | 07/19/2014 |
| The unusual DRB1*08:01 haplotype carrying DRB3*02:02 has been confirmed in a Dutch family. | The unusual DRB1*08:01 haplotype carrying DRB3*02:02 confirmed in a Dutch family.
Swelsen WT, Hartog KS, Ranzijn CM, Lardy NM. | 02/1/2014 |
| HLA-DRB3*02:02 on the DRB1*03:01 haplotype can contribute to type 1 diabetes risk. | Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes.
Erlich HA, Valdes AM, McDevitt SL, Simen BB, Blake LA, McGowan KR, Todd JA, Rich SS, Noble JA, Type 1 Diabetes Genetics Consortium (T1DGC)., Free PMC Article | 09/14/2013 |
| Prospective evaluation of matching for HLA-DRB3/4/5, -DQ, and -DP loci is warranted to reduce posttransplant risks in donor-recipient pairs matched for 7/8 HEL. | Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation.
Fernández-Viña MA, Klein JP, Haagenson M, Spellman SR, Anasetti C, Noreen H, Baxter-Lowe LA, Cano P, Flomenberg N, Confer DL, Horowitz MM, Oudshoorn M, Petersdorf EW, Setterholm M, Champlin R, Lee SJ, de Lima M., Free PMC Article | 08/3/2013 |
| Three sets of HLA-DR3-positive haplotypes are designed that provide maximum risk of type 1 diabetes development in Indians and suggest a common Caucasian ancestor from which multiple haplotypes evolve independently. | Genomic evaluation of HLA-DR3+ haplotypes associated with type 1 diabetes.
Kumar N, Kaur G, Tandon N, Kanga U, Mehra NK. | 07/6/2013 |
| Heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia. | Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
Loewenthal R, Rosenberg N, Kalt R, Dardik R, Landau M, Yahalom V, Avishai O, Frenkel O, Gazit E, Steinberg DM, Lipitz S, Salomon O. | 03/30/2013 |
| There was a strong sporadic inclusion body myositis association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. | Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis.
Rojana-udomsart A, Mitrpant C, James I, Witt C, Needham M, Day T, Kiers L, Corbett A, Martinez P, Wilton SD, Mastaglia FL. | 03/2/2013 |
| TNF associations with type 1 diabetes are caused by their linkage disequilibrium with specific HLA-DR3-DQ2 haplotypes in the Indian population. | Tumor necrosis factor-associated susceptibility to type 1 diabetes is caused by linkage disequilibrium with HLA-DR3 haplotypes.
Kumar N, Kaur G, Tandon N, Mehra N. | 01/26/2013 |
| In addition to confirming one of the top findings in the meta-analysis, TRIM26, RNF5 and HLA-DRB3 have been identified as potential candidate genes for schizophrenia. | Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes.
de Jong S, van Eijk KR, Zeegers DW, Strengman E, Janson E, Veldink JH, van den Berg LH, Cahn W, Kahn RS, Boks MP, Ophoff RA, PGC Schizophrenia (GWAS) Consortium., Free PMC Article | 12/29/2012 |
| There are no significant differences in the HLA-DRB3/B4/B5 homozygosity and heterozygosity rates between Korean males and females in both newborns and adults. | No gender differences in the frequencies of HLA-DRB3/B4/B5 heterozygotes in newborns and adults in Koreans.
Song EY, Roh EY, Shin S, Yoon JH, Park MH. | 09/8/2012 |
| All patients with sporadic inclusion body myositis carried the HLA-DRB1*0301 allele, or its equivalent HLA-DR3 serological specificity | The association of sporadic inclusion body myositis and Sjögren's syndrome in carriers of HLA-DR3 and the 8.1 MHC ancestral haplotype.
Rojana-udomsart A, Needham M, Luo YB, Fabian V, Walters S, Zilko PJ, Mastaglia FL. | 11/19/2011 |
| Patients with Wolfram syndrome have a different profile of the HLA antigens with the presence of DR2, DQw1 and DRB3/4 allele and are negative for diabetes-related autoantibodies | [An evaluation of HLA class 2 alleles and anti-islet antibodies as evidence for non-autoimmune diabetes in Wolfram syndrome].
Zmysłowska A, Borowiec M, Antosik K, Wyka K, Cieślik-Heinrich A, Klich I, Młynarski W. | 09/17/2011 |
| CatG cleaves human leukocyte antigen (HLA)-DR in vitro. Cleavage occurred on the loop between fx1 and fx2 of the membrane-proximal beta2 domain. In vivo, however, the CatG cleavage site is sterically inaccessible or masked by associated molecules. | Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules.
Burster T, Macmillan H, Hou T, Schilling J, Truong P, Boehm BO, Zou F, Lau K, Strohman M, Schaffert S, Busch R, Mellins ED., Free PMC Article | 08/30/2010 |
| IA2 positivity was associated with HLA-DR4/X and HLA-DR3/4 positivity, and hypothyroidism was linked to HLA-DR4/4. | HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.
Awa WL, Boehm BO, Kapellen T, Rami B, Rupprath P, Marg W, Becker M, Holl RW, DPV-Wiss Study Group and the German Competence Network Diabetes Mellitus. | 07/5/2010 |
| results suggest that DRB3 plays a significant role in antigen presentation with different epitopic preferences to DRB1. | Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.
Faner R, James E, Huston L, Pujol-Borrel R, Kwok WW, Juan M., Free PMC Article | 01/25/2010 |
| interactions between Tg and discrete HLA-DR pocket signatures contribute to the initiation of autoimmune thyroid disease | Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective.
Jacobson EM, Yang H, Menconi F, Wang R, Osman R, Skrabanek L, Li CW, Fadlalla M, Gandhi A, Chaturvedi V, Smith EP, Schwemberger S, Osterburg A, Babcock GF, Tomer Y., Free PMC Article | 01/21/2010 |