| Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression. | Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression.
Xie S, Xu C, Wu C, Lou Y, Duan J, Sang R, Lou Z, Hou J, Ge W, Xi Y, Yang X., Free PMC Article | 02/23/2023 |
| Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila. | Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila.
Wang Q, Fan H, Li F, Skeeters SS, Krishnamurthy VV, Song Y, Zhang K., Free PMC Article | 02/27/2021 |
| MEK inhibitor cobimetinib rescues a dRaf mutant lethal phenotype in Drosophila melanogaster. | MEK inhibitor cobimetinib rescues a dRaf mutant lethal phenotype in Drosophila melanogaster.
Pfeifle I, Bohnekamp J, Volkhardt A, Kirsten H, Rohwedder A, Thum A, Magin TM, Kunz M. | 10/24/2020 |
| Raf-activated intestinal stem cells and their progenies are very sensitive to apoptosis | Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila.
Ma M, Zhao H, Zhao H, Binari R, Perrimon N, Li Z., Free PMC Article | 08/6/2016 |
| Yorkie (Yki), a transcriptional coactivator in the Hippo pathway that regulates organ size, is required for Raf-induced cardiac hypertrophy in flies | Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription.
Yu L, Daniels JP, Wu H, Wolf MJ., Free PMC Article | 01/16/2016 |
| move from the oocyte to the follicle cells in process that does not require endocytosis | Germline and somatic vitelline proteins colocalize in aggregates in the follicular epithelium of Drosophila ovaries.
Furriols M, Casanova J., Free PMC Article | 10/3/2015 |
| These results suggest that ERK is necessary, but not sufficient, for Raf-mediated cardiac hypertrophy. | Raf-mediated cardiac hypertrophy in adult Drosophila.
Yu L, Daniels J, Glaser AE, Wolf MJ., Free PMC Article | 10/26/2013 |
| RNAi-mediated inhibition of MAPK-signaling by knockdown of Ras85D, phl/D-Raf or Dsor1/MEK affects larval development, adult life span and hemolymph phosphate, suggesting that some in vivo effects involve activation of this signaling pathway by phosphate. | Genetic determinants of phosphate response in Drosophila.
Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N., Free PMC Article | 09/14/2013 |
| RAF catalytic function is regulated in response to a specific mode of dimerization of its kinase domain, which we term the side-to-side dimer | A dimerization-dependent mechanism drives RAF catalytic activation.
Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. | 01/21/2010 |
| tyrosine 510 regulates Draf activation by affecting the autoinhibitory interaction between the N- and C-terminal fragments of the protein | Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila.
Xia F, Li J, Hickey GW, Tsurumi A, Larson K, Guo D, Yan SJ, Silver-Morse L, Li WX., Free PMC Article | 01/21/2010 |
| role in promotion of blood cell activation and differentiation in conjunction with hopscotch jak kinase | The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila.
Luo H, Rose PE, Roberts TM, Dearolf CR. | 01/21/2010 |
| pTyr 1253 (YE) Neu (ErbB-2) autophosphorylation site signalling requires Raf function. | Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.
Settle M, Gordon MD, Nadella M, Dankort D, Muller W, Jacobs JR. | 01/21/2010 |
| the integration of RTK-induced RAS and Src42 signals by CNK as a two-component input is essential for RAF activation | Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.
Laberge G, Douziech M, Therrien M., Free PMC Article | 01/21/2010 |