| Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference. | Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
Castro Alvarez JJ, Revel M, Carrasco J, Cléard F, Pauli D, Hilgers V, Karch F, Maeda RK., Free PMC Article | 01/8/2022 |
| The biological characters of Bmelav-like genes in the development of Bombyx mori. | The biological characters of Bmelav-like genes in the development of Bombyx mori.
Sun X, Zhang K, Gu J, Yang J, Huang Q, Yan R, Qin S, Hou C, Zhang G, Wang S, Li M. | 10/23/2021 |
| ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. | ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
Lee S, Wei L, Zhang B, Goering R, Majumdar S, Wen J, Taliaferro JM, Lai EC., Free PMC Article | 08/28/2021 |
| ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue. | ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
Carrasco J, Rauer M, Hummel B, Grzejda D, Alfonso-Gonzalez C, Lee Y, Wang Q, Puchalska M, Mittler G, Hilgers V. | 10/24/2020 |
| The Dscam1 long 3' UTR was found to be required for correct Elav-mediated skipping of exon 19. Elav thus co-regulates APA and alternative splicing to generate specific Dscam1 transcripts that are essential for neural development. | Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth.
Zhang Z, So K, Peterson R, Bauer M, Ng H, Zhang Y, Kim JH, Kidd T, Miura P., Free PMC Article | 08/1/2020 |
| Ubiquitous Elav has regulatory capacity, since derepressed Elav can stabilize an Elav-responsive sensor. Repression of Elav in non-neural territories is crucial as misexpression here has profoundly adverse consequences. | Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues.
Sanfilippo P, Smibert P, Duan H, Lai EC., Free PMC Article | 09/16/2017 |
| Paused Pol II promotes recruitment of ELAV to extended genes in Drosophila. | ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.
Oktaba K, Zhang W, Lotz TS, Jun DJ, Lemke SB, Ng SP, Esposito E, Levine M, Hilgers V., Free PMC Article | 04/18/2015 |
| The modulation of Hox RNA processing by ELAV serves to adapt the morphogenesis of the CNS to axial level by regulating Hox expression and consequently activating local programmes of neural differentiation. | The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system.
Rogulja-Ortmann A, Picao-Osorio J, Villava C, Patraquim P, Lafuente E, Aspden J, Thomsen S, Technau GM, Alonso CR., Free PMC Article | 07/12/2014 |
| Reducing Elav levels significantly suppressed the worniu mutant phenotype. | The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
Lai SL, Miller MR, Robinson KJ, Doe CQ., Free PMC Article | 02/9/2013 |
| RNA immunoprecipitation assays suggest that ELAV directly binds the proximal polyadenylation signals of many target mRNAs | ELAV mediates 3' UTR extension in the Drosophila nervous system.
Hilgers V, Lemke SB, Levine M., Free PMC Article | 12/22/2012 |
| ELAV/Hu protein-regulated alternative RNA processing is more conserved than anticipated from the alignment of degenerate low-complexity sequences. | ELAV-mediated 3'-end processing of ewg transcripts is evolutionarily conserved despite sequence degeneration of the ELAV-binding site.
Haussmann IU, Li M, Soller M., Free PMC Article | 01/21/2012 |
| An integral part of ELAV gene-specific regulation involves combinatorial binding to variably spaced short U-rich motifs on an extensive binding site. | Determinants of ELAV gene-specific regulation.
Soller M, Li M, Haussmann IU. | 11/13/2010 |
| The essential elav gene of Drosophila is newly emerged, restricted to dipterans and of retrotransposed origin | Rapid functional diversification in the structurally conserved ELAV family of neuronal RNA binding proteins.
Samson ML., Free PMC Article | 01/21/2010 |
| unexpectedly observed that, in addition to neurons, ELAV is transiently expressed in embryonic glial cells. Furthermore, it is transiently present in the proliferating longitudinal glioblast, and it is transcribed in embryonic neuroblasts. | The commonly used marker ELAV is transiently expressed in neuroblasts and glial cells in the Drosophila embryonic CNS.
Berger C, Renner S, Lüer K, Technau GM. | 01/21/2010 |
| Chromosome fusions from patterns of polymorphism at the X-linked elav gene were studied. | Inferences on the evolutionary history of the Drosophila americana polymorphic X/4 fusion from patterns of polymorphism at the X-linked paralytic and elav genes.
Vieira CP, Coelho PA, Vieira J., Free PMC Article | 01/21/2010 |
| ELAV multimerization and binding to multiple AU(4-6) motifs contribute to target RNA recognition and processing in a complex cellular environment | ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation.
Soller M, White K., Free PMC Article | 01/21/2010 |
| expression in combination with seven-up and prospero identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna | Combinatorial expression of Prospero, Seven-up, and Elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna.
Sen A, Reddy GV, Rodrigues V. | 01/21/2010 |