| MiR-34a-HK1 signal axis retards bone marrow mesenchymal stem cell senescence via ameliorating glycolytic metabolism. | MiR-34a-HK1 signal axis retards bone marrow mesenchymal stem cell senescence via ameliorating glycolytic metabolism.
Sun Y, Zhang C, Ma Q, Yu X, Gao X, Zhang H, Shi Y, Li Y, He X., Free PMC Article | 07/31/2024 |
| Hemokinin-1 is a mediator of chronic restraint stress-induced pain. | Hemokinin-1 is a mediator of chronic restraint stress-induced pain.
Borbély É, Kecskés A, Kun J, Kepe E, Fülöp B, Kovács-Rozmer K, Scheich B, Renner É, Palkovits M, Helyes Z., Free PMC Article | 03/14/2024 |
| Expanding the Molecular Spectrum of HK1-Related Charcot-Marie-Tooth Disease, Type 4G; the First Report in Iran. | Expanding the Molecular Spectrum of HK1-Related Charcot-Marie-Tooth Disease, Type 4G; the First Report in Iran.
Goleyjani Moghadam M, Elahi Z, Soveyzi M, Arzhangi S, Nafissi S, Najmabadi H, Kahrizi K, Fattahi Z., Free PMC Article | 02/12/2024 |
| Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications. | Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications.
Rabbani N, Thornalley PJ., Free PMC Article | 02/8/2024 |
| DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer. | DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer.
Ni Y, Zhuang Z. | 01/5/2024 |
| Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors. | Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.
Pasternack H, Polzer M, Gemoll T, Kümpers C, Sauer T, Lazar-Karsten P, Hinrichs S, Bohnet S, Perner S, Dressler FF, Kirfel J., Free PMC Article | 12/1/2023 |
| Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10. | Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.
Yang M, Cai W, Lin Z, Tuohuti A, Chen X., Free PMC Article | 11/15/2023 |
| Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation. | Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.
Qian Y, Chen D, Zhu Y, Wu J, Wang Y, Yang W. | 05/18/2023 |
| Expanding the neurodevelopmental phenotype associated with HK1 de novo heterozygous missense variants. | Expanding the neurodevelopmental phenotype associated with HK1 de novo heterozygous missense variants.
Poole RL, Badonyi M, Cozens A, Foulds N, Marsh JA, Rahman S, Ross A, Schooley J, Straub V, Quigley AJ, FitzPatrick D, Lampe A. | 02/14/2023 |
| Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism. | Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism.
Wakeling MN, Owens NDL, Hopkinson JR, Johnson MB, Houghton JAL, Dastamani A, Flaxman CS, Wyatt RC, Hewat TI, Hopkins JJ, Laver TW, van Heugten R, Weedon MN, De Franco E, Patel KA, Ellard S, Morgan NG, Cheesman E, Banerjee I, Hattersley AT, Dunne MJ, International Congenital Hyperinsulinism Consortium, Richardson SJ, Flanagan SE., Free PMC Article | 11/19/2022 |
| Location matters: hexokinase 1 in glucose metabolism and inflammation. | Location matters: hexokinase 1 in glucose metabolism and inflammation.
Sundaram SM, Doughty LA, Sereda MW. | 10/1/2022 |
| Overexpression of Protein Phosphatase 2 Regulatory Subunit B""Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma. | Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.
Jiao N, Ji WS, Zhang B, Shang YK, Zhang YC, Yu WQ, Jin HL, Li C, Zhang CY, Yan C, Yue W, Zhang Q. | 08/20/2022 |
| HK1 haemolytic anaemia in association with a neurological phenotype and co-existing CEP290 Meckel-Gruber in a Romani family. | HK1 haemolytic anaemia in association with a neurological phenotype and co-existing CEP290 Meckel-Gruber in a Romani family.
Sasaki E, Phelan E, O'Regan M, Kassim AH, Miletin J, McMahon C, O'Sullivan MJ, Baptista J, Lynch SA. | 04/2/2022 |
| Knockdown of long non-coding RNA small nucleolar RNA host gene 9 or hexokinase 2 both suppress endometrial cancer cell proliferation and glycolysis. | Knockdown of long non-coding RNA small nucleolar RNA host gene 9 or hexokinase 2 both suppress endometrial cancer cell proliferation and glycolysis.
Wang L, Huang Q, Lin Q, Chen L, Shi Q. | 08/28/2021 |
| High-resolution photoreceptor imaging analysis of patients with autosomal dominant retinitis pigmentosa (adRP) caused by HK1 mutation. | High-resolution photoreceptor imaging analysis of patients with autosomal dominant retinitis pigmentosa (adRP) caused by HK1 mutation.
Kubota D, Matsumoto K, Hayashi M, Oishi N, Gocho K, Yamaki K, Kobayakawa S, Igarashi T, Takahashi H, Kameya S. | 06/26/2021 |
| Biomarker study of the biological parameter and neurotransmitter levels in autistics. | Biomarker study of the biological parameter and neurotransmitter levels in autistics.
Meyyazhagan A, Balasubramanian B, Easwaran M, Alagamuthu KK, Shanmugam S, Kuchi Bhotla H, Pappusamy M, Arumugam VA, Thangaraj A, Kaul T, Keshavarao S, Cacabelos R. | 05/22/2021 |
| lncARSR sponges miR-34a-5p to promote colorectal cancer invasion and metastasis via hexokinase-1-mediated glycolysis. | lncARSR sponges miR-34a-5p to promote colorectal cancer invasion and metastasis via hexokinase-1-mediated glycolysis.
Li S, Zhu K, Liu L, Gu J, Niu H, Guo J., Free PMC Article | 12/19/2020 |
| The observed changes are suggestive of compositional changes in the subunit makeup of HK and PFK. The implication of these findings in relation to energy status of the diabetic erythrocyte and its interrelationship with loss of cell deformability are discussed here. | Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase.
Bhise S, Rao J, Hegde M, Katyare S. | 07/25/2020 |
| ADAM12S promotes the proliferation, colony formation, migration, and invasion of Small Cell Lung Cancer cells through upregulating HK1. | SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Duan Q, Li D, Xiong L, Chang Z, Xu G. | 07/25/2020 |
| Heterozygous mutation in HK1 gene is associated with retinitis pigmentosa. | Eleven-year follow-up of a Japanese retinitis pigmentosa patient with an HK1 gene mutation.
Sato S, Morimoto T, Hotta K, Fujikado T, Nishida K. | 06/13/2020 |
| De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment. | De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment.
Okur V, Cho MT, van Wijk R, van Oirschot B, Picker J, Coury SA, Grange D, Manwaring L, Krantz I, Muraresku CC, Hulick PJ, May H, Pierce E, Place E, Bujakowska K, Telegrafi A, Douglas G, Monaghan KG, Begtrup A, Wilson A, Retterer K, Anyane-Yeboa K, Chung WK., Free PMC Article | 06/13/2020 |
| a direct GTP-dependent interaction between KRAS4A and hexokinase 1 (HK1) is reported, that alters the activity of the kinase, and thereby establishes that HK1 is an effector of KRAS4A | KRAS4A directly regulates hexokinase 1.
Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, Balmain A, Kimmelman AC, Philips MR., Free PMC Article | 05/2/2020 |
| The results distinguished two ovarian cancer phenotypes, one with elevated HK activity and low G6Pase activity, and another with the opposite characteristics. | Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy.
Olsen BB, Gjedde A, Vilstrup MH, Johnsen IBG, Neumann G, Torigian DA, Alavi A, Høilund-Carlsen PF. | 08/3/2019 |
| Our replicated associations with HK1 and IL18R1 suggest that variants in inflammatory pathways, such as the biologically-plausible NLRP3 inflammasome, may contribute to nocturnal hypoxemia. | Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.
Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, Hillman DR, Johnson WC, Lederer DJ, Lee J, Loredo JS, Mei H, Mukherjee S, Patel SR, Post WS, Purcell SM, Ramos AR, Reid KJ, Rice K, Shah NA, Sofer T, Taylor KD, Thornton TA, Wang H, Yaffe K, Zee PC, Hanis CL, Palmer LJ, Rotter JI, Stone KL, Tranah GJ, Wilson JG, Sunyaev SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S., Free PMC Article | 05/11/2019 |
| The authors found that in addition to retinitis pigmentosa, HK1 E851K missense mutation can also cause dominant macular dystrophy and cone-rod dystrophy, which primarily affect cone photoreceptors instead of rods. | The phenotypic variability of HK1-associated retinal dystrophy.
Yuan Z, Li B, Xu M, Chang EY, Li H, Yang L, Wu S, Soens ZT, Li Y, Wong LC, Lewis RA, Sui R, Chen R., Free PMC Article | 02/16/2019 |