| ANGPTL3 is a novel HDL component that regulates HDL function. | ANGPTL3 is a novel HDL component that regulates HDL function.
Yang L, Wang Y, Xu Y, Li K, Yin R, Zhang L, Wang D, Wei L, Lang J, Cheng Y, Wang L, Ke J, Zhao D., Free PMC Article | 03/14/2024 |
| The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy. | The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Ma Y, Chen Y, Xu H, Du N., Free PMC Article | 09/12/2023 |
| METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma. | METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma.
Zhang Z, Fu J, Zhang Y, Qin X, Wang Y, Xing C., Free PMC Article | 06/23/2023 |
| The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway. | The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway.
Bini S, Pecce V, Di Costanzo A, Polito L, Ghadiri A, Minicocci I, Tambaro F, Covino S, Arca M, D'Erasmo L., Free PMC Article | 05/7/2022 |
| ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome. | ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome.
Zhong F, Liu S, Li Y, Li G, Liu M, Wang J, Cui W, Suo Y, Gao X., Free PMC Article | 04/23/2022 |
| Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8. | Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8.
Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ., Free PMC Article | 03/26/2022 |
| Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice. | Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice.
Bell TA 3rd, Liu M, Donner AJ, Lee RG, Mullick AE, Crooke RM., Free PMC Article | 03/26/2022 |
| Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance. | Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance.
Adam RC, Mintah IJ, Alexa-Braun CA, Shihanian LM, Lee JS, Banerjee P, Hamon SC, Kim HI, Cohen JC, Hobbs HH, Van Hout C, Gromada J, Murphy AJ, Yancopoulos GD, Sleeman MW, Gusarova V., Free PMC Article | 10/9/2021 |
| Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3. | Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3.
Qiu M, Glass Z, Chen J, Haas M, Jin X, Zhao X, Rui X, Ye Z, Li Y, Zhang F, Xu Q., Free PMC Article | 08/21/2021 |
| Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss. | Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss.
Dai R, Liu H, Han X, Liu J, Zhai Y, Rao J, Shen Q, Xu H., Free PMC Article | 09/5/2020 |
| Inhibition of ANGPTL3 alleviates adriamycin-induced nephropathy and proteinuria in mice. | Anti-proteinuria effect of antibody against ANGPTL3 coil-coiled domain on adriamycin-induced nephropathy in mice.
Han X, Dai R, Zhai Y, Shen Q, Sun L, Liu H, Xu H. | 07/11/2020 |
| Reduced secretion and increased uptake of ApoB-containing lipoproteins may contribute to the low LDL-C observed in mice with genetic ANGPTL3 deficiency. | Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.
Xu YX, Redon V, Yu H, Querbes W, Pirruccello J, Liebow A, Deik A, Trindade K, Wang X, Musunuru K, Clish CB, Cowan C, Fizgerald K, Rader D, Kathiresan S., Free PMC Article | 06/1/2019 |
| The role of ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases is reviewed here. | New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases.
Su X, Peng DQ., Free PMC Article | 09/8/2018 |
| ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3 | ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.
Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J., Free PMC Article | 01/20/2018 |
| The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice. | ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
Xiao HB, Wang JY, Sun ZL. | 12/9/2017 |
| Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b. | Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
Kang DY, S P N, Darvin P, Joung YH, Byun HJ, Do CH, Park KD, Park MN, Cho KH, Yang YM. | 10/14/2017 |
| This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 at different nutritional statuses. | A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase.
Fu Z, Abou-Samra AB, Zhang R., Free PMC Article | 10/22/2016 |
| Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion | Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.
Wang Y, Gusarova V, Banfi S, Gromada J, Cohen JC, Hobbs HH., Free PMC Article | 03/26/2016 |
| The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy. | A novel role of angiopoietin-like-3 associated with podocyte injury.
Liu J, Gao X, Zhai Y, Shen Q, Sun L, Feng C, Rao J, Liu H, Zha X, Guo M, Ma D, Zhang Z, Li R, Xu H. | 02/20/2016 |
| ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver | Hepatic ANGPTL3 regulates adipose tissue energy homeostasis.
Wang Y, McNutt MC, Banfi S, Levin MG, Holland WL, Gusarova V, Gromada J, Cohen JC, Hobbs HH., Free PMC Article | 01/16/2016 |
| Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC) through lentiviral transduction promoted HSC expansion. | Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells.
Farahbakhshian E, Verstegen MM, Visser TP, Kheradmandkia S, Geerts D, Arshad S, Riaz N, Grosveld F, van Til NP, Meijerink JP., Free PMC Article | 06/27/2015 |
| Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation. | Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin α(V)β₃/FAK/PI3K pathway-mediated Rac1 activation.
Lin Y, Rao J, Zha XL, Xu H., Free PMC Article | 06/14/2014 |
| Furin has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase in hepatocytes | Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG., Free PMC Article | 12/21/2013 |
| ANGPTL8, a paralog of ANGPTL3 that arose through duplication of an ancestral DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other ANGPTLs | Atypical angiopoietin-like protein that regulates ANGPTL3.
Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, Valenzuela DM, Murphy AJ, Cohen JC, Hobbs HH., Free PMC Article | 02/23/2013 |
| Angptl3, as an extrinsic factor, thus supports the stemness of hematopoietic stem cells in the bone marrow niche. | Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche.
Zheng J, Huynh H, Umikawa M, Silvany R, Zhang CC., Free PMC Article | 02/26/2011 |