| Involvement of ANO1 currents in pacemaking of PDGFRalpha-positive specialised smooth muscle cells in rat caudal epididymis. | Involvement of ANO1 currents in pacemaking of PDGFRα-positive specialised smooth muscle cells in rat caudal epididymis.
Kudo W, Mitsui R, Hashitani H. | 08/1/2024 |
| Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive role in the tactile allodynia induced by REM sleep deprivation in rats. | Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive role in the tactile allodynia induced by REM sleep deprivation in rats.
Martínez-Magaña CJ, Muñoz-Castillo PA, Murbartián J. | 06/26/2024 |
| The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI). | The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI).
Chen Q, Kong L, Xu Z, Cao N, Tang X, Gao R, Zhang J, Deng S, Tan C, Zhang M, Wang Y, Zhang L, Ma K, Li L, Si J., Free PMC Article | 03/26/2022 |
| Local Ca(2+) signals couple activation of TRPV1 and ANO1 sensory ion channels. | Local Ca(2+) signals couple activation of TRPV1 and ANO1 sensory ion channels.
Shah S, Carver CM, Mullen P, Milne S, Lukacs V, Shapiro MS, Gamper N., Free PMC Article | 11/6/2021 |
| ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway. | ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway.
Tian X, Sun C, Wang X, Ma K, Chang Y, Guo Z, Si J. | 09/25/2021 |
| Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells. | Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells.
Guo P, Liu Y, Xu X, Ma G, Hou X, Fan Y, Zhang M. | 07/31/2021 |
| Dual role of Ca(2+)-activated Cl(-) channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro. | Dual role of Ca(2+)-activated Cl(-) channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro.
Sui J, Zhang C, Fang X, Wang J, Li Y, Wang J, Wang L, Dong J, Zhou Z, Li C, Chen J, Ma T, Chen D., Free PMC Article | 03/13/2021 |
| [Expression of ANO1 during cardiac fibroblasts differentiation and its electrophysiological characteristics as calcium-activated chloride channel protein]. | [Expression of ANO1 during cardiac fibroblasts differentiation and its electrophysiological characteristics as calcium-activated chloride channel protein].
Tian XQ, Tan CY, Li NN, Chang YQ, Zhang AM, Zhou Y, Ma KT, Si JQ. | 01/23/2021 |
| TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels. | TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels.
Genovese M, Borrelli A, Venturini A, Guidone D, Caci E, Viscido G, Gambardella G, di Bernardo D, Scudieri P, Galietta LJV. | 09/12/2020 |
| TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension. | TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension.
Askew Page HR, Dalsgaard T, Baldwin SN, Jepps TA, Povstyan O, Olesen SP, Greenwood IA., Free PMC Article | 09/5/2020 |
| Ca(2+) sparks may couple to TMEM16A channels and trigger pressure-induced myogenic constriction via membrane depolarization in renal afferent arterioles. | Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole.
Yip KP, Balasubramanian L, Kan C, Wang L, Liu R, Ribeiro-Silva L, Sham JSK., Free PMC Article | 09/21/2019 |
| Bile acids stimulate Cl(-) secretion in biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca(2+) ]i . | Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A Cl(-) channels.
Li Q, Dutta A, Kresge C, Bugde A, Feranchak AP., Free PMC Article | 12/29/2018 |
| The expression of TGF-beta and p-smad3 declined after anoctamin-1 (ANO1) over-expression in cardiac fiborblasts. | ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway.
Gao Y, Zhang YM, Qian LJ, Chu M, Hong J, Xu D., Free PMC Article | 12/22/2018 |
| TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands. | TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands.
Yamamura H, Nishimura K, Hagihara Y, Suzuki Y, Imaizumi Y., Free PMC Article | 12/1/2018 |
| Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries. | Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.
Wang Q, Leo MD, Narayanan D, Kuruvilla KP, Jaggar JH., Free PMC Article | 06/3/2017 |
| There is functional anoctamin-1 and bestrophin-1 expression in rats at sites related to nociceptive processing. | Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.
Pineda-Farias JB, Barragán-Iglesias P, Loeza-Alcocer E, Torres-López JE, Rocha-González HI, Pérez-Severiano F, Delgado-Lezama R, Granados-Soto V., Free PMC Article | 03/12/2016 |
| Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl- channel, contributes to spontaneous hypertension | Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl- channel, contributes to spontaneous hypertension.
Wang B, Li C, Huai R, Qu Z. | 01/16/2016 |
| ANO1 is essential for the development of prostate hyperplasia. | Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia.
Cha JY, Wee J, Jung J, Jang Y, Lee B, Hong GS, Chang BC, Choi YL, Shin YK, Min HY, Lee HY, Na TY, Lee MO, Oh U., Free PMC Article | 11/21/2015 |
| ANO1 in thyrocytes functions as a calcium-activated channel mediating iodide efflux, and may contribute to the rapid delivery of iodide into the follicular lumen for the synthesis of thyroid hormones following activation by calcium-mobilizing stimuli | Anoctamin 1 is apically expressed on thyroid follicular cells and contributes to ATP- and calcium-activated iodide efflux.
Iosco C, Cosentino C, Sirna L, Romano R, Cursano S, Mongia A, Pompeo G, di Bernardo J, Ceccarelli C, Tallini G, Rhoden KJ. | 06/20/2015 |
| Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery | Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery.
Pritchard HA, Leblanc N, Albert AP, Greenwood IA., Free PMC Article | 05/30/2015 |
| Ano1 is expressed in the bladder and plays a role in its spontaneous phasic contractile activity. | Anoctamin-1 in the juvenile rat urinary bladder.
Bijos DA, Drake MJ, Vahabi B., Free PMC Article | 05/23/2015 |
| Data suggest that ANO1 is responsible for most of the iodide efflux across the apical membrane of thyroid cells. | Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte.
Twyffels L, Strickaert A, Virreira M, Massart C, Van Sande J, Wauquier C, Beauwens R, Dumont JE, Galietta LJ, Boom A, Kruys V. | 02/14/2015 |
| TMEM16A in A549 inhibits LPS-induced NF-kappaB activation and decreases proinflammatory cytokines release, protecting A549 from acute lipopolysaccharide-mediated damage | TMEM16A protein attenuates lipopolysaccharide-mediated inflammatory response of human lung epithelial cell line A549.
Zhang A, Yan X, Li H, Gu Z, Zhang P, Zhang H, Li Y, Yu H. | 01/31/2015 |
| Data indicate that ANO1 channels form signaling complexes with IP3 receptor (IP3R1) and GPCRs bradykinin receptor 2 (B2R) and protease-activated receptor 2 (PAR-2). | Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor.
Jin X, Shah S, Liu Y, Zhang H, Lees M, Fu Z, Lippiat JD, Beech DJ, Sivaprasadarao A, Baldwin SA, Zhang H, Gamper N., Free PMC Article | 04/5/2014 |
| It was demonstrated for the first time that the ICl.Ca activity and TMEM16A expression are enhanced in pulmonary artery smooth muscle of chronicly hypoxic rats. | Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity.
Sun H, Xia Y, Paudel O, Yang XR, Sham JS., Free PMC Article | 06/22/2013 |