| Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats. | Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats.
Yiğit N, Duman MT, Çetintürk D, Saygılı-Yiğit F, Çolak E, Çolak R., Free PMC Article | 05/15/2023 |
| Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations. | Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations.
Krijger IM, Strating M, van Gent-Pelzer M, van der Lee TAJ, Burt SA, Schroeten FH, de Vries R, de Cock M, Maas M, Meerburg BG., Free PMC Article | 02/11/2023 |
| VKORC1 single nucleotide polymorphisms in rodents in Spain. | VKORC1 single nucleotide polymorphisms in rodents in Spain.
Bermejo-Nogales A, Rodríguez Martín JA, Coll J, Navas JM. | 10/15/2022 |
| Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management. | Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management.
Damin-Pernik M, Hammed A, Giraud L, Goulois J, Benoît E, Lattard V. | 05/7/2022 |
| VKORC1 mutations in rodent populations of a tropical city-state as an indicator of anticoagulant rodenticide resistance. | VKORC1 mutations in rodent populations of a tropical city-state as an indicator of anticoagulant rodenticide resistance.
Chua C, Humaidi M, Neves ES, Mailepessov D, Ng LC, Aik J., Free PMC Article | 05/7/2022 |
| The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus). | The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus).
Takeda K, Ikenaka Y, Fourches D, Tanaka KD, Nakayama SMM, Triki D, Li X, Igarashi M, Tanikawa T, Ishizuka M. | 04/3/2021 |
| A VKORC1-based SNP survey of anticoagulant rodenticide resistance in the house mouse, Norway rat and roof rat in the USA. | A VKORC1-based SNP survey of anticoagulant rodenticide resistance in the house mouse, Norway rat and roof rat in the USA.
Díaz JC, Kohn MH. | 12/26/2020 |
| These studies evaluated the association between vitamin K dietary deficiency and mutations in the VKORC1 enzyme. | Establishment of the Variation of Vitamin K Status According to Vkorc1 Point Mutations Using Rat Models.
Debaux JV, Hammed A, Barbier B, Chetot T, Benoit E, Lefebvre S, Lattard V., Free PMC Article | 02/22/2020 |
| Mutation in VKORC1 associated with a limited vitamin K intake is thus a major risk for cardiovascular disease. Our model is the first non-invasive rat model that shows spontaneous medial calcifications and would be useful for studying physiological function of vitamin K. | Missense mutation of VKORC1 leads to medial arterial calcification in rats.
Michaux A, Matagrin B, Debaux JV, Schurgers LJ, Benoit E, Lattard V., Free PMC Article | 11/9/2019 |
| This study demonstrated that elevated CYP450 oxidative metabolism leading to accelerated difenacoum detoxification is involved in the Berkshire phenotype of L120Q mutation in Vkorc1. | Elevated difenacoum metabolism is involved in the difenacoum-resistant phenotype observed in Berkshire rats homozygous for the L120Q mutation in the vitamin K epoxide reductase complex subunit 1 (Vkorc1) gene.
Boitet M, Hammed A, Chatron N, Debaux JV, Benoit E, Lattard V. | 09/8/2018 |
| In a rat model of chronic kidney disease, there was a decrease in the thoracic aorta expression of Vkor and Ggcx enzymes, and a decrease in the kidney level of vitamin K1 to MK-4 bioconversion enzyme Ubiad1. | Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
McCabe KM, Booth SL, Fu X, Ward E, Adams MA, Holden RM. | 01/13/2018 |
| The aim of this study was to determine the distribution of VKORC1 1173C > T and VKORC1 -1639G > A polymorphisms, which are most important for warfarin therapy | Vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphisms in population of Eastern Croatia.
Mandić D, Mandić S, Horvat V, Samardzija M, Samardzija M. | 04/5/2014 |
| The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists. | VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
Hammed A, Matagrin B, Spohn G, Prouillac C, Benoit E, Lattard V., Free PMC Article | 12/7/2013 |
| The differences in kinetics of VKOR activity between warfarin-resistant and sensitive rats were studied. | A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.
Tanaka KD, Kawai YK, Ikenaka Y, Harunari T, Tanikawa T, Fujita S, Ishizuka M. | 09/28/2013 |
| An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance. | Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?
Rost S, Pelz HJ, Menzel S, MacNicoll AD, León V, Song KJ, Jäkel T, Oldenburg J, Müller CR., Free PMC Article | 01/21/2010 |
| identified, by using linkage information from three species the gene VKORC1 which encodes a small transmembrane protein of the endoplasmic reticulum; VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain | Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hörtnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Müller CR, Strom TM, Oldenburg J. | 01/21/2010 |
| The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1. | The genetic basis of resistance to anticoagulants in rodents.
Pelz HJ, Rost S, Hünerberg M, Fregin A, Heiberg AC, Baert K, MacNicoll AD, Prescott CV, Walker AS, Oldenburg J, Müller CR., Free PMC Article | 01/21/2010 |