| Data suggest that LEF1-dependent genes in zebrafish hypothalamus are associated with anxiety; LEF1 null mutant zebrafish exhibit increased anxiety. | Lef1-dependent hypothalamic neurogenesis inhibits anxiety.
Xie Y, Kaufmann D, Moulton MJ, Panahi S, Gaynes JA, Watters HN, Zhou D, Xue HH, Fung CM, Levine EM, Letsou A, Brennan KC, Dorsky RI., Free PMC Article | 10/14/2017 |
| mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 expression) in zebrafish embryos. | Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1.
Hübner K, Grassme KS, Rao J, Wenke NK, Zimmer CL, Korte L, Müller K, Sumanas S, Greber B, Herzog W. | 10/7/2017 |
| Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt/beta-catenin effector Lef1. | Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish.
Agarwala S, Duquesne S, Liu K, Boehm A, Grimm L, Link S, König S, Eimer S, Ronneberger O, Lecaudey V., Free PMC Article | 07/2/2016 |
| Lef1 has a role in regulating Dusp6 in formation of the zebrafish posterior lateral line primordium | Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium.
Matsuda M, Nogare DD, Somers K, Martin K, Wang C, Chitnis AB., Free PMC Article | 07/20/2013 |
| Nlk2 is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells. | NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells.
Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T., Free PMC Article | 06/16/2012 |
| Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate. | Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development.
Valdivia LE, Young RM, Hawkins TA, Stickney HL, Cavodeassi F, Schwarz Q, Pullin LM, Villegas R, Moro E, Argenton F, Allende ML, Wilson SW., Free PMC Article | 11/5/2011 |
| Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. | Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
McGraw HF, Drerup CM, Culbertson MD, Linbo T, Raible DW, Nechiporuk AV., Free PMC Article | 11/5/2011 |
| Data conclude that lef1-mediated Wnt signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy. | Lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish.
Gamba L, Cubedo N, Lutfalla G, Ghysen A, Dambly-Chaudiere C. | 03/19/2011 |
| Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a in regulating lef1. | Dnmt3 and G9a cooperate for tissue-specific development in zebrafish.
Rai K, Jafri IF, Chidester S, James SR, Karpf AR, Cairns BR, Jones DA., Free PMC Article | 04/12/2010 |
| Domain-specific regulation of foxP2 CNS expression by lef1. | Domain-specific regulation of foxP2 CNS expression by lef1.
Bonkowsky JL, Wang X, Fujimoto E, Lee JE, Chien CB, Dorsky RI., Free PMC Article | 01/21/2010 |
| high-affinity binding sites for Tcf/Lef1 within the boz promoter region | Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression.
Leung T, Söll I, Arnold SJ, Kemler R, Driever W. | 01/21/2010 |
| Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. | Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis.
Lee JE, Wu SF, Goering LM, Dorsky RI. | 01/21/2010 |