| Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. | Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats.
Alzuri SE, Rosas NM, Hlavacova N, Jezova D, Fuchsova B. | 05/30/2023 |
| Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons. | Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons.
Aparicio GI, León A, Gutiérrez Fuster R, Ravenscraft B, Monje PV, Scorticati C., Free PMC Article | 05/22/2023 |
| Overexpression of M6a is accompanied by an increase in spine density, particularly in mature spines. | Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis.
Formoso K, Garcia MD, Frasch AC, Scorticati C. | 01/13/2018 |
| Formation of filopodia by membrane glycoprotein M6a (Gpm6a) requires actin regulator coronin-1a (Coro1a), known to regulate plasma membrane localization and activation of Rac1 and its downstream effector Pak1. | Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated kinase 1 (Pak1).
Alvarez Juliá A, Frasch AC, Fuchsova B. | 08/20/2016 |
| we analyzed the functional contribution of transmembrane domains (TMDs) of the neuronal membrane glycoprotein M6a | Filopodia formation driven by membrane glycoprotein M6a depends on the interaction of its transmembrane domains.
Formoso K, García MD, Frasch AC, Scorticati C. | 10/10/2015 |
| Gestational stress affected gpm6a gene expression in offspring likely through changes in methylation status and in posttranscriptional regulation by microRNAs | Prenatal stress changes the glycoprotein GPM6A gene expression and induces epigenetic changes in rat offspring brain.
Monteleone MC, Adrover E, Pallarés ME, Antonelli MC, Frasch AC, Brocco MA., Free PMC Article | 04/25/2015 |
| Association of neuronal M6a with cholesterol-rich lipid rafts is important for M6a glycoprotein's role in filopodia formation and signal propagation. | Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts.
Scorticati C, Formoso K, Frasch AC. | 12/3/2011 |
| Data suggest that M6a is a key molecule for dendritic spine formation during development. | Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation.
Brocco MA, Fernández ME, Frasch AC. | 05/31/2010 |
| The present study shows that chronic stress also regulates expression of M6a, a glycoprotein which is localised in axonal membranes. | Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress.
Cooper B, Fuchs E, Flügge G., Free PMC Article | 01/21/2010 |
| M6a is an axonal component of glutamatergic neurons and that it is localized to distinct sites of the axonal plasma membrane of pyramidal and granule cells | Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.
Cooper B, Werner HB, Flügge G. | 01/21/2010 |
| M6a plays an important role in neurite outgrowth and filopodium/spine formation and may be, at least in part, responsible for plastic alterations found in the hippocampus of chronically stressed animals | The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation.
Alfonso J, Fernández ME, Cooper B, Flugge G, Frasch AC., Free PMC Article | 01/21/2010 |
| M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation. | M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation.
Mukobata S, Hibino T, Sugiyama A, Urano Y, Inatomi A, Kanai Y, Endo H, Tashiro F. | 01/21/2010 |