| data demonstrate that tbx6l and tbx16 genes function redundantly to direct tail somite development | tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis.
Morrow ZT, Maxwell AM, Hoshijima K, Talbot JC, Grunwald DJ, Amacher SL., Free PMC Article | 06/2/2018 |
| The Tbx16 regulates the timing of collinear hox gene activation to coordinate the anterior-posterior fates and positions of paraxial Mesodermal progenitor cells (MPCs). | Tbx16 regulates hox gene activation in mesodermal progenitor cells.
Payumo AY, McQuade LE, Walker WJ, Yamazoe S, Chen JK., Free PMC Article | 05/20/2017 |
| Ntla and Spt do not differentially regulate medial floor plate (MPF) induction along the anterior-posterior axis; rather, the T-box genes act redundantly within margin derived cells to promote the posterior extension of MFP progenitors. | Optochemical dissection of T-box gene-dependent medial floor plate development.
Payumo AY, Walker WJ, McQuade LE, Yamazoe S, Chen JK., Free PMC Article | 03/12/2016 |
| Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors. | Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.
Manning AJ, Kimelman D., Free PMC Article | 02/20/2016 |
| high levels of Wnt signaling induce a transition to mesoderm by directly activating tbx16, which in turn acts to irreversibly flip a bistable switch, leading to maintenance of the mesodermal fate and repression of the bipotential progenitor state | Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm.
Bouldin CM, Manning AJ, Peng YH, Farr GH 3rd, Hung KL, Dong A, Kimelman D., Free PMC Article | 10/10/2015 |
| observed normal cardiac convergence in spt(-/-) and ntl(-/-) embryos implying that these novel roles of spt and ntl in PGP migration cannot be explained simply by generalised effects on midline convergence | Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis.
Huang CJ, Wilson V, Pennings S, MacRae CA, Mullins J. | 01/18/2014 |
| Zebrafish Tbx16 regulates intermediate mesoderm cell fate by attenuating Fgf activity. | Zebrafish Tbx16 regulates intermediate mesoderm cell fate by attenuating Fgf activity.
Warga RM, Mueller RL, Ho RK, Kane DA., Free PMC Article | 12/21/2013 |
| Results uncover a novel Sdc2-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis. | Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry.
Arrington CB, Peterson AG, Yost HJ., Free PMC Article | 11/23/2013 |
| These data suggest that spt expression and BMP inhibition are both required for somitic precursors to exit the tailbud. | BMP signaling and spadetail regulate exit of muscle precursors from the zebrafish tailbud.
O'Neill K, Thorpe C., Free PMC Article | 04/20/2013 |
| Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives. | The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1.
Fior R, Maxwell AA, Ma TP, Vezzaro A, Moens CB, Amacher SL, Lewis J, Saúde L., Free PMC Article | 02/2/2013 |
| The developmental expression of tbx16-expressing cells using a transgene possessing 7.5 kb of DNA sequence surrounding the site of transcription initiation of the tbx16 gene, was studied. | Transgenic zebrafish recapitulating tbx16 gene early developmental expression.
Wells S, Nornes S, Lardelli M., Free PMC Article | 10/22/2011 |
| Data demonstrate that the spadetail mutation creates a reversible block in the maturation program, stalling cells in the transition state. | Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail.
Row RH, Maître JL, Martin BL, Stockinger P, Heisenberg CP, Kimelman D., Free PMC Article | 08/6/2011 |
| Tbx16 regulates Wnt signaling in the developing zebrafish intermediate mesoderm. | Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation.
Mueller RL, Huang C, Ho RK., Free PMC Article | 01/1/2011 |
| Tbx16 regulates apical clustering of KV cells | Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish.
Amack JD, Wang X, Yost HJ. | 01/21/2010 |
| investigate whether loss of Brachyury/Notail or Tbx16/Spadetail disrupts the balance of Nodal ligands (Southpaw) and antagonists (Charon) around Kupffers Vesicle | Nodal activity around Kupffer's vesicle depends on the T-box transcription factors Notail and Spadetail and on Notch signaling.
Gourronc F, Ahmad N, Nedza N, Eggleston T, Rebagliati M. | 01/21/2010 |
| in embryos with reduced function of the T-box transcription factor Tbx16 (Spadetail) or its genetic target paraxial protocadherin (Papc), synchrony is lost, coalesence is disrupted, and the midline domain is misshaped | Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer.
Muyskens JB, Kimmel CB., Free PMC Article | 01/21/2010 |
| The irregular distribution of spt-expressing neural cells along the rostrocaudal axis of the spinal cord may be due to "inefficient" patterning of neural spt expression by a signal(s) from flanking, regularly distributed somites also expressing spt. | The identity and distribution of neural cells expressing the mesodermal determinant spadetail.
Tamme R, Wells S, Conran JG, Lardelli M., Free PMC Article | 01/21/2010 |
| Interplay between FGF, one-eyed pinhead (zoep), and T-box transcription factors spt and ntl during zebrafish posterior development. | Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development.
Griffin KJ, Kimelman D. | 01/21/2010 |
| Spadetail (T-box gene 16) and one-eyed pintail protein genetically interact and are together essential for the formation of cardiac and somitic mesoderm. | One-Eyed Pinhead and Spadetail are essential for heart and somite formation.
Griffin KJ, Kimelman D. | 01/21/2010 |
| ntl function is required to repress medial floor plate and promote notochord fate in cells of the wild-type notochord domain and spt and ntl together are required non cell-autonomously for medial floor plate formation. | The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate.
Amacher SL, Draper BW, Summers BR, Kimmel CB. | 01/21/2010 |