| Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium. | Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium.
Marques IJ, Ernst A, Arora P, Vianin A, Hetke T, Sanz-Morejón A, Naumann U, Odriozola A, Langa X, Andrés-Delgado L, Zuber B, Torroja C, Osterwalder M, Simões FC, Englert C, Mercader N., Free PMC Article | 04/23/2022 |
| Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish. | Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.
Andrés-Delgado L, Galardi-Castilla M, Mercader N, Santamaría L. | 08/14/2021 |
| Study summarizes the different roles of WT1a gene in the embryonic zebrafish kidney, the adult kidney and the cardiac development as well. [review] | Function and Regulation of the Wilms' Tumor Suppressor 1 (WT1) Gene in Fish.
Perner B, Bates TJ, Naumann U, Englert C. | 02/3/2018 |
| Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue. | Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish.
Chou CW, Lin J, Jiang YJ, Liu YW. | 12/23/2017 |
| In summary, our results show that WT1 is a crucial transcription factor for podocyte maturation and maintenance. | Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance.
Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, Groth M, Witzgall R, Gröne HJ, Platzer M, Englert C., Free PMC Article | 11/28/2015 |
| Knockdown of wt1a disrupted podocyte differentiation and prevented expression of osr1. | osr1 is required for podocyte development downstream of wt1a.
Tomar R, Mudumana SP, Pathak N, Hukriede NA, Drummond IA., Free PMC Article | 01/10/2015 |
| embryos treated with morpholinos against wt1a, foxc1a, or the Notch transcriptional mediator rbpj develop fewer podocytes, as determined by wt1b, hey1 and nephrin expression, while embryos deficient in any two of these factors completely lack podocytes | Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish.
O'Brien LL, Grimaldi M, Kostun Z, Wingert RA, Selleck R, Davidson AJ., Free PMC Article | 11/26/2011 |
| Results describe the first functional demonstration of defined regulatory elements controlling Wt1 expression in vivo. | A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros.
Bollig F, Perner B, Besenbeck B, Köthe S, Ebert C, Taudien S, Englert C. | 01/21/2010 |
| While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis. | The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.
Perner B, Englert C, Bollig F. | 01/21/2010 |
| Both wt1a and wt1b are expressed in the intermediate mesoderm, with wt1b being restricted to a smaller area lying at the caudal end of the wt1a expression domain | Identification and comparative expression analysis of a second wt1 gene in zebrafish.
Bollig F, Mehringer R, Perner B, Hartung C, Schäfer M, Schartl M, Volff JN, Winkler C, Englert C. | 01/21/2010 |
| Wt1 is required for its initial restricted expression in pronephros. It also appears to be involved in interrenal development and ff1b expression. | Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b.
Hsu HJ, Lin G, Chung BC. | 01/21/2010 |