| both Smp and beta-catenin function in a common molecular pathway with cx43 to influence both evx1 expression and joint location. | Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43.
Bhattacharya S, Gargiulo D, Iovine MK., Free PMC Article | 04/13/2019 |
| Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal. | Two Different Functions of Connexin43 Confer Two Different Bone Phenotypes in Zebrafish.
Misu A, Yamanaka H, Aramaki T, Kondo S, Skerrett IM, Iovine MK, Watanabe M., Free PMC Article | 12/17/2016 |
| serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone responsible for proper folding of procollagen molecules. | Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin.
Bhadra J, Iovine MK. | 09/24/2016 |
| Hapln1a-ECM stabilizes the secreted growth factor Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration. | Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration.
Govindan J, Tun KM, Iovine MK., Free PMC Article | 07/30/2016 |
| Hapln1a has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton | Hapln1a is required for connexin43-dependent growth and patterning in the regenerating fin skeleton.
Govindan J, Iovine MK., Free PMC Article | 01/10/2015 |
| increased expression in Dupuytren's disease | Expression of gap junction proteins connexins 26, 30, and 43 in Dupuytren's disease.
Holzer LA, Cör A, Holzer G., Free PMC Article | 04/19/2014 |
| Sema3d functions in a common molecular pathway with Cx43 cell proliferation and joint formation | Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration.
Ton QV, Kathryn Iovine M., Free PMC Article | 07/6/2013 |
| Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL) exhibited osteogenic characteristics, in which Cx43 played an important role. | Upregulated expression of connexin43 in spinal ligament fibroblasts derived from patients presenting ossification of the posterior longitudinal ligament.
Yang HS, Lu XH, Chen DY, Yuan W, Yang LL, He HL, Chen Y. | 05/12/2012 |
| Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role. | Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts.
Ramkisoensing AA, Pijnappels DA, Askar SF, Passier R, Swildens J, Goumans MJ, Schutte CI, de Vries AA, Scherjon S, Mummery CL, Schalij MJ, Atsma DE., Free PMC Article | 03/3/2012 |
| Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor. | Cross-talk between angiotensin II and IGF-1-induced connexin 43 expression in human saphenous vein smooth muscle cells.
Jia G, Aggarwal A, Yohannes A, Gangahar DM, Agrawal DK., Free PMC Article | 01/14/2012 |
| These results of this study suggested that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology. | Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers.
Ernst C, Nagy C, Kim S, Yang JP, Deng X, Hellstrom IC, Choi KH, Gershenfeld H, Meaney MJ, Turecki G. | 12/3/2011 |
| Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45. | Cytokine effects on gap junction communication and connexin expression in human bladder smooth muscle cells and suburothelial myofibroblasts.
Heinrich M, Oberbach A, Schlichting N, Stolzenburg JU, Neuhaus J., Free PMC Article | 10/1/2011 |
| Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis. | Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
Jiang Q, Liu D, Sun S, Hu J, Tan L, Wang Y, Gui Y, Yu M, Song H. | 02/26/2011 |
| Cx43 is crucial for TJ reassembly at the blood-testis barrier during its cyclic restructuring throughout the seminiferous epithelial cycle of spermatogenesis | Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly.
Li MW, Mruk DD, Lee WM, Cheng CY., Free PMC Article | 11/27/2010 |
| Neonatal murine atrial myocytes showed similar abundances of Cx40 and Cx43 proteins, while ventricular myocytes contained at least 20 times more Cx43 than Cx40. | Connexin40 and connexin43 determine gating properties of atrial gap junction channels.
Lin X, Gemel J, Glass A, Zemlin CW, Beyer EC, Veenstra RD., Free PMC Article | 05/3/2010 |
| There was a lack of membranous distribution of connexins or a shift from moderately membranous immunoreactivity to predominantly cytoplasmic accumulation of CX32 and CX43 in studied colon tumors. | Gradual loss of functional gap junction within progression of colorectal cancer -- a shift from membranous CX32 and CX43 expression to cytoplasmic pattern during colorectal carcinogenesis.
Kanczuga-Koda L, Koda M, Sulkowski S, Wincewicz A, Zalewski B, Sulkowska M. | 04/19/2010 |
| role of Cx43.4 appears to be conserved given that its ortholog, human Cx45, is able to functionally compensate for zebrafish Cx43.4 during L-R patterning | A gap junction connexin is required in the vertebrate left-right organizer.
Hatler JM, Essner JJ, Johnson RG. | 01/21/2010 |
| Results reveal a correlation between the level of Cx43 expression in the fin ray mesenchyme and the location of joints in developing zebrafish. | Connexin43 regulates joint location in zebrafish fins.
Sims K Jr, Eble DM, Iovine MK., Free PMC Article | 01/21/2010 |
| Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. | Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration.
Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK., Free PMC Article | 01/21/2010 |
| Measurable differences in Cx43 function may be correlated with the severity of defects in bone length. | Zebrafish short fin mutations in connexin43 lead to aberrant gap junctional intercellular communication.
Hoptak-Solga AD, Klein KA, DeRosa AM, White TW, Iovine MK., Free PMC Article | 01/21/2010 |
| The fin length mutant short fin (sof), which causes defects in the length of bony fin ray segments, is caused by mutations in the connexin43 (cx43) gene. | Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins.
Iovine MK, Higgins EP, Hindes A, Coblitz B, Johnson SL. | 01/21/2010 |
| molecular cloning; Cx43alpha1 gap junctions are likely to have conserved roles in vertebrate embryonic development | Developmental regulation and expression of the zebrafish connexin43 gene.
Chatterjee B, Chin AJ, Valdimarsson G, Finis C, Sonntag JM, Choi BY, Tao L, Balasubramanian K, Bell C, Krufka A, Kozlowski DJ, Johnson RG, Lo CW. | 01/21/2010 |
| Cx48.5, Cx44.1, Cx43 have roles in lens development | Expression of connexin48.5, connexin44.1, and connexin43 during zebrafish (Danio rerio) lens development.
Cheng S, Christie T, Valdimarsson G. | 01/21/2010 |