| Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. | Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.
Hou Y, Zheng S, Zou F, Wang D, Da H, Zhou Y, Fan X, Liu J, Zhao H, He J, Li H, Sun X, Liu Y. | 08/30/2023 |
| that Spdef regulates baseline Muc5b expression in respiratory epithelia but does not contribute to Muc5b regulation in a mouse model of Muc5b-predominant mucus obstruction caused by airway dehydration | Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice.
Chen G, Volmer AS, Wilkinson KJ, Deng Y, Jones LC, Yu D, Bustamante-Marin XM, Burns KA, Grubb BR, O'Neal WK, Livraghi-Butrico A, Boucher RC., Free PMC Article | 04/20/2019 |
| a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF. | Androgen deprivation therapy-induced epithelial-mesenchymal transition of prostate cancer through downregulating SPDEF and activating CCL2.
Tsai YC, Chen WY, Abou-Kheir W, Zeng T, Yin JJ, Bahmad H, Lee YC, Liu YN. | 07/14/2018 |
| In studies of mice and human CRC, we found that SPDEF induces a quiescent state in CRC cells by disrupting binding of b-catenin to TCF1 and TCF3 and regulation of genes that control the cell cycle. | SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin.
Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF., Free PMC Article | 09/9/2017 |
| SPDEF causes goblet cell differentiation and Th2 inflammation during postnatal development and is required for goblet cell metaplasia and normal Th2 inflammatory responses to house dust mite aeroallergen. | Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.
Rajavelu P, Chen G, Xu Y, Kitzmiller JA, Korfhagen TR, Whitsett JA., Free PMC Article | 08/22/2015 |
| SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. | SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.
Cheng XH, Black M, Ustiyan V, Le T, Fulford L, Sridharan A, Medvedovic M, Kalinichenko VV, Whitsett JA, Kalin TV., Free PMC Article | 07/25/2015 |
| Spdef(-/-) mice have an ocular surface phenotype similar to that in moderate dry eye, providing a new, more convenient model for the disease. | Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.
Marko CK, Menon BB, Chen G, Whitsett JA, Clevers H, Gipson IK., Free PMC Article | 10/26/2013 |
| SPDEF inhibited the expression of beta-catenin-target genes in mouse colon tumors, and interacted with beta-catenin to block its transcriptional activity in CRC cell lines, resulting in lower levels of cyclin D1 and c-MYC. | SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.
Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF., Free PMC Article | 06/15/2013 |
| Our data reveal a novel nonredundant role for Serpinb3a in mediating mucus production through regulation of sterile alpha motif pointed domain containing v-ets avian erythroblastosis virus E26 oncogene homolog transcription factor expression | A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK., Free PMC Article | 02/26/2011 |
| Spdef functions in secretory intestinal cells and suggest a common molecular mechanism for maturation of gastrointestinal secretory lineages. | Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.
Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M, Zhang X, Chen W, Li YP, Shivdasani RA, Libermann TA., Free PMC Article | 12/4/2010 |
| Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression | Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression.
Schaefer JS, Sabherwal Y, Shi HY, Sriraman V, Richards J, Minella A, Turner DP, Watson DK, Zhang M., Free PMC Article | 05/10/2010 |
| Spdef was sufficient to inhibit proliferation of intestinal progenitors and induce differentiation into goblet cells. | SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells.
Noah TK, Kazanjian A, Whitsett J, Shroyer NF., Free PMC Article | 03/1/2010 |
| These data show that SPDEF plays a critical role in regulating a transcriptional network mediating the goblet cell differentiation and mucus hyperproduction associated with chronic pulmonary disorders. | SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA., Free PMC Article | 02/15/2010 |
| The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. | The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.
Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H. | 01/21/2010 |
| SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo. | SPDEF regulates goblet cell hyperplasia in the airway epithelium.
Park KS, Korfhagen TR, Bruno MD, Kitzmiller JA, Wan H, Wert SE, Khurana Hershey GK, Chen G, Whitsett JA., Free PMC Article | 01/21/2010 |