| MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic Shock by Inhibiting SIRT6 Expression. | MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic Shock by Inhibiting SIRT6 Expression.
Ma X, Liu M. | 10/22/2024 |
| Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats. | Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
Zhang Y, Yang Z, Xu Z, Wan J, Hua T, Sun Q. | 08/27/2024 |
| USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6. | USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
Song M, Yi F, Zeng F, Zheng L, Huang L, Sun X, Huang Q, Deng J, Wang H, Gu W. | 08/26/2024 |
| Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway. | Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
Xu H, Guo H, Tang Z, Hao R, Wang S, Jin P. | 08/9/2024 |
| SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats. | SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats.
Jia J, Tao W, Chen T, Zhong Q, Sun J, Xu Y, Sui X, Chen C, Zhang Z. | 02/15/2024 |
| Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged. | Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged.
Moon YJ, Cui B, Cho SY, Hwang JW, Chung HC, Kwon J, Kim D, Jang KY, Kim JR, Wang SI., Free PMC Article | 08/28/2023 |
| DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo. | DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo.
Hou Y, Shi J, Guo Y, Shi G., Free PMC Article | 06/15/2023 |
| Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells. | Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells.
Tao Y, Wu Y, Jiang C, Wang Q, Geng X, Chen L, Zhou S, Wang X, Han M, Du D, Ding B, Li X. | 03/31/2023 |
| Overexpressing SIRT6 can Attenuate the Injury of Intracerebral Hemorrhage by Down-Regulating NF-kB. | Overexpressing SIRT6 can Attenuate the Injury of Intracerebral Hemorrhage by Down-Regulating NF-kB.
Cheng J, Fan YQ, Zhang WF, Zhang G, Zeng K, Ye Z, Zhao D, Wu LQ, Chen ZB. | 03/23/2023 |
| SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3). | SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3).
Wang J, Liu Z, Lu J, Zou J, Ye W, Li H, Gao S, Liu P. | 03/14/2023 |
| Downregulation of Sirt6 by CD38 promotes cell senescence and aging. | Downregulation of Sirt6 by CD38 promotes cell senescence and aging.
Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X., Free PMC Article | 12/31/2022 |
| SIRT6 Prevents Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Rats. | SIRT6 Prevents Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Rats.
Fang L, Zhang G, Wu Y, Li Z, Gao S, Zhou L., Free PMC Article | 10/29/2022 |
| Isoflurane alleviates hypoxia/reoxygenation induced myocardial injury by reducing miR-744 mediated SIRT6. | Isoflurane alleviates hypoxia/reoxygenation induced myocardial injury by reducing miR-744 mediated SIRT6.
Chen G, Zhang F, Wang L, Feng Z. | 07/9/2022 |
| Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP. | Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP.
Song MY, Yi F, Xiao H, Yin J, Huang Q, Xia J, Yin XM, Wen YB, Zhang L, Liu YH, Xiao B, Gu WP., Free PMC Article | 05/21/2022 |
| SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKalpha-mTORC1 pathway. | SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway.
Bian C, Zhang H, Gao J, Wang Y, Li J, Guo D, Wang W, Song Y, Weng Y, Ren H. | 05/14/2022 |
| Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons. | Sirtuin 6 is a regulator of dendrite morphogenesis in rat hippocampal neurons.
Matsuno H, Tsuchimine S, Fukuzato N, O'Hashi K, Kunugi H, Sohya K. | 11/22/2021 |
| Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury. | Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury.
Zhaohui C, Shuihua W. | 07/17/2021 |
| MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway. | MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway.
Ruan ZF, Xie M, Gui SJ, Lan F, Wan J, Li Y. | 07/3/2021 |
| Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy. | Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy.
Yuan X, Chen G, Guo D, Xu L, Gu Y. | 04/3/2021 |
| Influence of the maternal high-intensity-interval-training on the cardiac Sirt6 and lipid profile of the adult male offspring in rats. | Influence of the maternal high-intensity-interval-training on the cardiac Sirt6 and lipid profile of the adult male offspring in rats.
Mohammadkhani R, Khaledi N, Rajabi H, Salehi I, Komaki A., Free PMC Article | 10/10/2020 |
| Study indicated that Sirt6 functioned as an immune response regulatory factor in renal inflammatory injury induced by streptozotocin administration in rats. | Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy.
Ji L, Chen Y, Wang H, Zhang W, He L, Wu J, Liu Y., Free PMC Article | 12/21/2019 |
| the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers. These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease. | Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Carreira MC, Izquierdo AG, Amil M, Casanueva FF, Crujeiras AB., Free PMC Article | 02/2/2019 |
| Data indicates that SIRT6 is involved in the modulation of depressive-like behaviors and affects the survival and synaptic plasticity of hippocampal neuron via inhibitory activation of Akt-GSK3beta signaling. | Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt/GSK3β signaling pathway.
Mao Q, Gong X, Zhou C, Tu Z, Zhao L, Wang L, Wang X, Sun L, Xia J, Lian B, Chen J, Mu J, Yang D, Xie P. | 12/16/2017 |
| SIRT6 positively regulates autophagy in cardiomyocytes. | SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
Lu J, Sun D, Liu Z, Li M, Hong H, Liu C, Gao S, Li H, Cai Y, Chen S, Li Z, Ye J, Liu P. | 07/1/2017 |
| p300 is involved in the protective effect of SIRT6 against phenylephrine-induced cardiomyocyte hypertrophy | SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.
Shen P, Feng X, Zhang X, Huang X, Liu S, Lu X, Li J, You J, Lu J, Li Z, Ye J, Liu P. | 05/20/2017 |