| p38gamma and p38delta modulate innate immune response by regulating MEF2D activation. | p38γ and p38δ modulate innate immune response by regulating MEF2D activation.
Escós A, Diaz-Mora E, Pattison M, Fajardo P, González-Romero D, Risco A, Martín-Gómez J, Bonneil É, Sonenberg N, Jafarnejad SM, Sanz-Ezquerro JJ, Ley SC, Cuenda A., Free PMC Article | 08/4/2023 |
| Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats. | Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
Venediktova N, Solomadin I, Starinets V., Free PMC Article | 02/15/2023 |
| The pro-tumorigenic activity of p38gamma overexpression in nasopharyngeal carcinoma. | The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma.
Yin DP, Zheng YF, Sun P, Yao MY, Xie LX, Dou XW, Tian Y, Liu JS., Free PMC Article | 04/23/2022 |
| p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1. | p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
Santamans AM, Montalvo-Romeral V, Mora A, Lopez JA, González-Romero F, Jimenez-Blasco D, Rodríguez E, Pintor-Chocano A, Casanueva-Benítez C, Acín-Pérez R, Leiva-Vega L, Duran J, Guinovart JJ, Jiménez-Borreguero J, Enríquez JA, Villlalba-Orero M, Bolaños JP, Aspichueta P, Vázquez J, González-Terán B, Sabio G., Free PMC Article | 12/25/2021 |
| In mouse hepatocytes, p38gamma induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38gamma or treatment with the p38gamma inhibitor pirfenidone protects against the chemically induced formation of liver tumours. | p38γ is essential for cell cycle progression and liver tumorigenesis.
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G. | 12/21/2019 |
| Mitogen-activated protein kinases p38gamma/p38delta deficiency protects against Candida albicans infection by increasing reactive oxygen species and iNOS enzyme production and thus the antifungal capacity of neutrophils and macrophages. | Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A., Free PMC Article | 03/30/2019 |
| p38gamma mitogen-activated protein kinase mediates inflammatory signaling to promote colon tumorigenesis | p38γ MAPK is required for inflammation-associated colon tumorigenesis.
Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K, Thomas JP, Myers CR, Stoner G, Chen G. | 07/30/2016 |
| p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy | p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.
González-Terán B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernández-Cosido L, Mora A, Crainiciuc G, Sáiz ML, Bernardo E, Leiva-Vega L, Rodríguez E, Bondía V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G., Free PMC Article | 07/30/2016 |
| p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation. | p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.
González-Terán B, López JA, Rodríguez E, Leiva L, Martínez-Martínez S, Bernal JA, Jiménez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G., Free PMC Article | 06/11/2016 |
| Findings provide genetic evidence that p38gamma and p38delta have essential roles in skin tumour development. | Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.
Zur R, Garcia-Ibanez L, Nunez-Buiza A, Aparicio N, Liappas G, Escós A, Risco A, Page A, Saiz-Ladera C, Alsina-Beauchamp D, Montans J, Paramio JM, Cuenda A., Free PMC Article | 04/16/2016 |
| Together, our results establish that p38gamma and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma and p38kappa as potential targets for cancer therapy. | Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer.
Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estévez M, Collantes E, Montans J, Cuenda A. | 01/10/2015 |
| An energetic signal may trigger phosphorylation of the p38-gamma isoform which may explain how contractions differentially activate signaling pathways. | Selective inhibition of ATPase activity during contraction alters the activation of p38 MAP kinase isoforms in skeletal muscle.
Brault JJ, Pizzimenti NM, Dentel JN, Wiseman RW., Free PMC Article | 09/6/2014 |
| p38gamma and p38delta are crucial regulators of inflammatory joint destruction in collagen-induced arthritis. | Alternative p38 MAPKs are essential for collagen-induced arthritis.
Criado G, Risco A, Alsina-Beauchamp D, Pérez-Lorenzo MJ, Escós A, Cuenda A. | 08/23/2014 |
| p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. | p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G., Free PMC Article | 11/17/2012 |
| p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation | p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.
Risco A, del Fresno C, Mambol A, Alsina-Beauchamp D, MacKenzie KF, Yang HT, Barber DF, Morcelle C, Arthur JS, Ley SC, Ardavin C, Cuenda A., Free PMC Article | 10/6/2012 |
| results indicate that p38gamma and p38delta have a role in the suppression of tumor development | Evidence of p38γ and p38δ involvement in cell transformation processes.
Cerezo-Guisado MI, del Reino P, Remy G, Kuma Y, Arthur JS, Gallego-Ortega D, Cuenda A. | 09/17/2011 |
| p38gamma contributes to the ability of cells to cope with UV exposure by regulating the checkpoint signaling pathways and the repair of damaged DNA | p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage.
Wu CC, Wu X, Han J, Sun P., Free PMC Article | 07/2/2011 |
| Results show that p38alpha is essential for myoblast differentiation, and p38gamma has a minor, yet opposing antimyogenic, function. | Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation.
Lovett FA, Cosgrove RA, Gonzalez I, Pell JM. | 10/23/2010 |
| p38-gamma signaling directly induces the assembly of a repressive MyoD transcriptional complex. | p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program.
Gillespie MA, Le Grand F, Scimè A, Kuang S, von Maltzahn J, Seale V, Cuenda A, Ranish JA, Rudnicki MA., Free PMC Article | 02/15/2010 |
| Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation. | Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation.
Wang H, Xu Q, Xiao F, Jiang Y, Wu Z., Free PMC Article | 01/21/2010 |
| This study constitutes the first analysis addressing the functionality of p38beta, p38gamma and p38delta in satellite cell-dependent adult muscle regeneration and growth. | Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases.
Ruiz-Bonilla V, Perdiguero E, Gresh L, Serrano AL, Zamora M, Sousa-Victor P, Jardí M, Wagner EF, Muñoz-Cánoves P. | 01/21/2010 |
| Mapk14 antagonizes Mapk12 activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. | p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.
Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G. | 01/21/2010 |
| hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription | Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.
Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D. | 01/21/2010 |
| Cardiac expression and subcellular localization | Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).
Court NW, dos Remedios CG, Cordell J, Bogoyevitch MA. | 01/21/2010 |