| Results indicate that midbrain Kcnq4 expression regulates alcohol-related behaviors and provide evidence that KV7.4 channels are a critical mediator of excessive alcohol drinking. | Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.
McGuier NS, Rinker JA, Cannady R, Fulmer DB, Jones SR, Hoffman M, Mulholland PJ., Free PMC Article | 02/16/2019 |
| Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered. | Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
Zimmer J, Takahashi T, Hofmann AD, Puri P. | 12/2/2017 |
| EPAC-dependent vasorelaxations occur in part via activation of Kv7 channels. This contributes to the isoproterenol-mediated relaxation in mesenteric, but not renal, arteries. | Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.
Stott JB, Barrese V, Greenwood IA., Free PMC Article | 06/24/2017 |
| is concluded that K(V)7 channels, via nifedipine sensitive channels, have a role in the regulation of basal renal vascular tone. | K(V)7.4 channels participate in the control of rodent renal vascular resting tone.
Salomonsson M, Brasen JC, Braunstein TH, Hagelqvist P, Holstein-Rathlou NH, Sorensen CM. | 03/12/2016 |
| In cerebral arteries, Kv7.4 and Kv7.5 proteins exist predominantly as a functional heterotetramer, which regulates intrinsic myogenicity and vasodilation attributed to CGRP. | Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Chadha PS, Jepps TA, Carr G, Stott JB, Zhu HL, Cole WC, Greenwood IA. | 05/24/2014 |
| Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels. | Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
Brueggemann LI, Mackie AR, Cribbs LL, Freda J, Tripathi A, Majetschak M, Byron KL., Free PMC Article | 03/29/2014 |
| In 2 different rat and mouse models of hypertension, the functional impact of Kv7 channels was dramatically downregulated. | Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
Jepps TA, Chadha PS, Davis AJ, Harhun MI, Cockerill GW, Olesen SP, Hansen RS, Greenwood IA. | 01/14/2012 |
| Findings show that K(V)7/KCNQ channels were functionally expressed in primary cultured OLCs and might play an important role in OPCs functioning in physiological or pathological conditions. | K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells.
Wang W, Gao XF, Xiao L, Xiang ZH, He C., Free PMC Article | 12/31/2011 |
| KCNQ4 potassium channel contributes to the regulation of myogenic control of cerebral artery diameter. | Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
Zhong XZ, Harhun MI, Olesen SP, Ohya S, Moffatt JD, Cole WC, Greenwood IA., Free PMC Article | 06/25/2011 |
| among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. | Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS., Free PMC Article | 01/21/2010 |
| KCNQ channels set the resting membrane potential of inner hair cells in the isolated organ of Corti and maintain [Ca2+]i at low levels | Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels.
Oliver D, Knipper M, Derst C, Fakler B., Free PMC Article | 01/21/2010 |
| In outer hair cells, TH enhanced the expression of the prestin gene through TRbeta. Simultaneously Kcnq4 expression was activated in the same cells by derepression of TRalpha1. | Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells.
Winter H, Braig C, Zimmermann U, Geisler HS, Fränzer JT, Weber T, Ley M, Engel J, Knirsch M, Bauer K, Christ S, Walsh EJ, McGee J, Köpschall I, Rohbock K, Knipper M. | 01/21/2010 |