| APC-beta-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. | APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis.
Blomain ES, Rappaport JA, Pattison AM, Bashir B, Caparosa E, Stem J, Snook AE, Waldman SA., Free PMC Article | 12/19/2020 |
| Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. | Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.
Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J. | 12/29/2018 |
| Both guanylin and uroguanylin trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity. | Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes.
Rodríguez A, Gómez-Ambrosi J, Catalán V, Ezquerro S, Méndez-Giménez L, Becerril S, Ibáñez P, Vila N, Margall MA, Moncada R, Valentí V, Silva C, Salvador J, Frühbeck G. | 02/24/2018 |
| Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC. | Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.
Lan D, Niu J, Miao J, Dong X, Wang H, Yang G, Wang K, Miao Y., Free PMC Article | 01/27/2018 |
| The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines. | Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.
Brenna Ø, Furnes MW, Munkvold B, Kidd M, Sandvik AK, Gustafsson BI., Free PMC Article | 05/20/2017 |
| In summary the structural analysis of missense SNPs is important to decrease the number of potential mutations to be in vitro evaluated for associating them with some genetic diseases | Computational analyses and prediction of guanylin deleterious SNPs.
Porto WF, Franco OL, Alencar SA. | 03/5/2016 |
| There is differential expression of guanylin in colorectal cancer, and the differential expression is associated with tumor stage. | [Differential expression of guanylin in colorectal cancer].
Chen YB, Zhu YP, Feng HY, Liu Y, Qian J, Fan YT, Li DC. | 06/14/2010 |
| The myristoylated wild-type GCAP1 was found to have the highest Ca(2+) affinity and thermal stability. | Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.
Dell'Orco D, Behnen P, Linse S, Koch KW., Free PMC Article | 03/22/2010 |
| guanylin as a significant marker in salivary gland tumor pathology | Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains.
Kulaksiz H, Rehberg E, Stremmel W, Cetin Y., Free PMC Article | 01/21/2010 |
| Guanylin plays a role in the regulation of ion transport in the colon | Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells.
Albano F, de Marco G, Canani RB, Cirillo P, Buccigrossi V, Giannella RA, Guarino A. | 01/21/2010 |
| human cortical collecting duct cells are depolarized by guanylin. | Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts.
Sindić A, Hirsch JR, Velic A, Piechota H, Schlatter E. | 01/21/2010 |
| It is likely that gallbladder epithelial cells synthesize and release guanylin into the bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway. | Guanylin regulates chloride secretion in the human gallbladder via the bile fluid.
Kulaksiz H, Schlenker T, Rost D, Stiehl A, Volkmann M, Lehnert T, Cetin Y, Stremmel W. | 01/21/2010 |
| hormone prosequence interactions provide an explanation for the negligible bioactivity of the prohormone as well as the important role of the NH2-terminal residues in the disulfide-coupled folding of proguanylin | Solution structure of human proguanylin: the role of a hormone prosequence.
Lauber T, Neudecker P, Rösch P, Marx UC. | 01/21/2010 |
| Results from circular dichroism and NMR spectroscopy validate native and recombinant proguanylin to be well-structured proteins adopting identical secondary structures and three-dimensional folds. | Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution.
Lauber T, Nourse A, Schulz A, Marx UC. | 01/21/2010 |